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송재윤 ( Jae Yun Song ),( Myung Ji Kim ),( Seong Min Kim ),( Hyo Sock Bae ),( Jae Kwan Lee ),( Nak Woo Lee ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Objective: The purpose of this study was to evaluate risk factors of vaginal cuff dehiscence or evisceration according to the type of operation. Methods: Medical records of 604 women who underwent hysterectomies at Korea University Anam Hospital between June 2007 and June 2011 were reviewed. They were allocated to six groups. The six types of hysterectomies included robotic hysterectomy (n = 7), robotic radical hysterectomy and node dissection (RRHND. n = 9), totallaparoscopic hysterectomy (TLH, n = 274), laparoscopy assisted vaginal hysterectomy (LAVH. n = 238), laparoscopic radical hysterectomy and node dissection (n = 11), and abdominal radical hysterectomy (ARH. n = 63). The characteristics and outcomes of each groups were compared. Results: There was no difference in the characteristics of patients between 6 groups. In total of 604 hysterectomies, 3 evisceration (0.49%) and 21 dehiscences (3.47%) occurred. Evisceration were found in RRHND (1/9, 11 ,1%), TLH (1/276, 0,36%), and ARH (1/63, 1,56%), Dehiscences occurred in TLH (15/274, 5.42%), LAVH (4/238, 1.68%), and ARH (2163, 3.17%), In 169 cases of TLH with intra-corporeal continuous suture, 1 evisceration and 4 dehiscences occurred, whereas 11 dehiscences occurred in 105 TLH cases with vaginal continuous locking suture (2.96% vs. 10.47%, P= 0.02). Conclusion: The incidence of vaginal cuff dehiscenceand eviscerationwas significantly higher in TLH than LAVH. The intra-corporeal cuff suture was superior to the vaginal suture to prevent the vaginal cuff complications in TLH.
자궁육종의 임상양상과 DNA Flow Cytometry의 분석
송재윤 ( Jae Yun Song ),박현태 ( Hyun Tae Park ),서동주 ( Dong Ju Soe ),이낙우 ( Nak Woo Lee ),김영태 ( Young Tae Kim ),이규완 ( Kyu Wan Lee ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.11
목적: 이 연구의 목적은 본원에서 1990년부터 1995년까지 이루어졌던 9명의 자궁육종환자를 대상으로 한 흐름세포측정 결과가 환자수가 적고 추적관찰기간이 짧아서 통계적 유의성을 증명하지 못하였던 바 5년간의 추가관찰을 통해 자궁육종의 임상양상과 DNA 흐름세포측정 분석에 대하여 알아보고자 한다. 연구 방법: 1990년 1월부터 2000년 12월까지 본원에서 진단 받은 26명의 자궁육종환자를 대상으로 의무기록을 분석하였으며 그중 18명은 파라핀 포매조직 Objective: To evaluate the clinicopathological characteristics and DNA flow cytometry in uterine sarcoma. Methods: A retrospective review of twenty six patients diagnosed and treated for a uterine sarcoma in Korea university hospital from 1990 to 2000 has
자궁내막암, 자궁내막증식증, 정상자궁내막에 있어서 CD44 Variant 6 (V6)의 발현
송재윤 ( Jae Yun Song ),박현태 ( Hyun Tae Park ),이낙우 ( Nack Woo Lee ),김영태 ( Young Tae Kim ),김인선 ( In Sun Kim ),이규완 ( Kyu Wan Lee ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.9
목적 : 정상 자궁내막과, 자궁내막증식증 (endometrial hyperplasia), 그리고 자궁내막암 (endometrial cancer)에 있어서 CD44 V6의 표현의 차이와 CD44 V6의 자궁내막암의 예후예측인자로서의 여부에 대하여 알아보고자 한다. 연구 방법 : 1991년부터 2001년까지 본원에서 진단된 총 76명의 환자를 대상으로 자궁내막증식증 (endometrial hyperplasia) 15예, 자궁내막암 24예 그리고 정상내막 37예를 대상으로 하였으며 면역양성반응과 면역강도를 종합하여 면역활성도 (immunoreactivity)를 평가하였다. 결과 : 정상조직이나 자궁내막증식증에 비해서 자궁내막암의 경우 통계학적으로 유의한 양성 소견을 나타내었다. (P<0.05) 면역활성도를 자궁근층의 침범이 나타나기 이전의 Ia와 침범이 나타나는 Ib 이상으로 나누어 보면 통계학적 유의성을 나타내지는 못하였다. 조직분화도에 따른 면역활성도는 grade 1에서 유의한 증가를 나타내었다. 결론 : CD44 V6의 표현은 자궁내막암의 조기진단에 이용될 수 있으며 자궁내막암의 예후예측인자로서도 이용될 수 있으리라 사료된다. Objective : To compare the expression of CD44 V6 in normal endometrium, endometrial hyperplasia, and endometrial cancer and to evaluate CD44 variant 6 for prognostic marker. Methods : Seventy six endometrial samples at Korea University Anam Hospital from 1991 to 2001 (37normal endometirum, 15 endometrial hyperplasia, and 24 endometrial cancer ) were immunohistochemically investigated for the expression of variant 6, isoform of CD44. Immunoreactivity scores were generated by multiplication of the values for the immunopositivity and immunointensity. Results : CD44 V6 was detected in 19/37 cases of normal endometrium (only secretory phase), 1/15 endometrial hyperplasia, and 24/24 endometrial cancer. Immunoreactivity was higher in well differentiated endometrial cancer, while no association was noted with cancer stage. Conclusion : CD44 V6 expression in normal endometrium is observed in the secretory phase. Detection of expression of CD44 V6 may be useful for the early diagnosis of endometrial cancer and may be an useful prognostic marker.
유민지 ( Min Ji Ryu ),정예원 ( Ye Won Chung ),배효숙 ( Hyo Sook Bae ),이재관 ( Jae Kwan Lee ),이낙우 ( Nak Woo Lee ),송재윤 ( Jae Yun Song ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.10
Primary retroperitoneal squamous cell carcinoma is very rare. A 66-year-old woman presented with right leg edema and pain that had developed one month prior. Pelvis magnetic resonance imaging showed the presence of a mass around the iliac vessels invading the iliacus muscle, right femoral head and obturator muscle. The patient underwent an exploratory laparotomy but the mass was not completely removed. The patient was treated with concurrent chemoradiation therapy with paclitaxel-carboplatin and Tomotherapy three weeks after surgery. After that, she conducted a further seven cycles of different chemotherapy. A abdomen CT scan after the last seven cycles showed a reduction in the size of the primary mass from 7.2 to 6.6 cm, consistent with a partial response to treatment. As a result, the role of adjuvant chemotherapy in these tumors is controversial. And it is considered that complete resection is more important.