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김두영,이철규,송영광 충북대학교 과학교육연구소 1992 과학교육연구논총 Vol.9 No.1
As part of a program to evaluate the catalytic role of metal ions between the drug and DNA, the interactions of various transition metal ions with nalidixic acid(1-ethy1-1, 4-dihydro-7-methy1-4-oxo-1, 8-naphthylridine-3-carboxylic acid)have been studied using potentiometric titration methods, in an ionc medium of 0.1 M(NaCl)at 25℃. The copper nalidixate complexes are formed with abnormally large stability constant, as might have been expected chelation and additive efffect. This results revealed that there was a specific requirement for cu^2+ion, and that the bactricidal activity was associated with the formation of chelate complex.