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송진우 ( Song Jin U ),김명환 ( Kim Myeong Hwan ),서욱장 ( Seo Ug Jang ),오동렬 ( O Dong Lyeol ),김기덕 ( Kim Gi Deog ),문성훈 ( Mun Seong Hun ),양동훈 ( Yang Dong Hun ),송문희 ( Song Mun Hui ),이상수 ( Lee Sang Su ),서동완 ( Seo D 대한소화기학회 2003 대한소화기학회지 Vol.42 No.5
Eosinophilic pancreatitis is a rare disorder that may only be diagnosed after pancreatic resection under the suspection of a pancreatic tumor. We experienced a 65-year-old female patient whose initial presentation suggested pancreatic cancer. Radiologic evaluation revealed a pancreatic mass-like lesion which was obstructing the main pancreatic duct. Endoscopic retrograde cholangiopancreatography (ERCP) showed double duct strictures involving the distal common bile duct and the main pancreatic duct. Serum IgE level was elevated. Percutaneous core needle biopsy with an 18-gauge needle was performed targeting the pancreatic lesion. The biopsy specimen revealed fibrotic interlobular septum and intralobular fibrosis with prominent eosinophilic infiltration. The patient was treated with oral prednisolone (40 mg/day). A plastic stent was inserted into the narrowed common bile duct. After three months of oral steroid therapy, symptoms and signs improved rapidly and serum IgE level was decreased. Abdominal computed tomography and ERCP revealed remission of pancreatic mass-like lesion. (Korean J Gastroenterol 2003;42:444-449)
김자영 ( Kim Ja Yeong ),김명환 ( Kim Myeong Hwan ),이상수 ( Lee Sang Su ),송문희 ( Song Mun Hui ),박도현 ( Park Do Hyeon ),서동완 ( Seo Dong Wan ),이성구 ( Lee Seong Gu ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 서양에서는 원발성 경화성 담관염 환자들에 대한 임상적 특성이 많이 보고되고 있으나 아직 국내에서는 소수의 환자들을 대상으로 한 증례보고에 그치고 있다. 이에 저자들은 본원에서 확진된 28예의 원발성 경화성 담관염 환자들의 임상상에 대해 알아보고자 하였다. <방법> 지난 10년간 본원에서 진단된 원발성 경화성 담관염 28예를 대상으로 하였고 의무기록지 검토를 통한 후향적 방법으로 조사하였다. <결과> 환자의 평균나이는 42.3±16.0 (17~7
김규표 ( Kim Gyu Pyo ),김명환 ( Kim Myeong Hwan ),이윤정 ( Lee Yun Jeong ),송문희 ( Song Mun Hui ),박도현 ( Park Do Hyeon ),이상수 ( Lee Sang Su ),서동완 ( Seo Dong Wan ),이성구 ( Lee Seong Gu ),민영일 ( Min Yeong Il ),송동은 ( So 대한소화기학회 2004 대한소화기학회지 Vol.43 No.2
Background/Aims: Autoimmune pancreatitis is a distinctive type of chronic pancreatitis with reversibility. We analyzed the largest number of patients with autoimmune pancreatitis among the studies carried out at a single institution in Korea. Methods: We retrospectively analyzed the clinical, radiologic, laboratory and histologic features in 17 patients who were diagnosed as autoimmune pancreatitis. Results: The patients were predominately elderly men who presented with jaundice or nonspecific gastrointestinal symptoms. In most of the patients, serum pancreatic enzymes were normal or mildly elevated with an accompanying cholestatic biochemical profile. Elevated IgG levels and detection of autoantibodies were observed in 47% (8/17) and 35% (6/17), respectively. Thirteen patients showed histologic findings of lymphoplasmacytic infiltration and fibrosis, and one patient showed predominant infiltration of eosinophils. Fifteen patients revealed radiologic images of diffuse swelling of pancreas and the sclerosing pattern on direct pancreatogram. All of the features improved in response to oral steroid therapy. Two cases showed focal narrowing with upstream duct dilatation and thus, they were diagnosed as focal type. Diabetes mellitus concurred in 13 cases and primary sclerosing cholangitis and Sjoren`s syndrome were present in 1 case, respectively. Conclusions: The recognition of autoimmune pancreatitis allows patients to avoid unnecessary surgery and recover with the administration of oral steroid. (Korean J Gastroenterol 2004; 43:112-119)
김자영 ( Kim Ja Yeong ),김명환 ( Kim Myeong Hwan ),김성두 ( Kim Seong Du ),이장한 ( Lee Jang Han ),안성기 ( An Seong Gi ),박도현 ( Park Do Hyeon ),송문희 ( Song Mun Hui ),이상수 ( Lee Sang Su ),서동완 ( Seo Dong Wan ),이성구 ( Lee 대한내과학회 2004 대한내과학회지 Vol.66 No.2
목적 : 원발성 경화성 담관염은 간내 또는 간외 담관의 다발성 협착을 특징으로 하는 원인 미상의 만성 염증성 질환이다. 이 질환은 담관벽의 점진적인 섬유화를 초래하여 담즙성 간경변을 거쳐 결국 간부전으로 진행한다. 저자들은 본원에서 경험한 28예의 원발성 경화성 담관염의 임상상을 분석하였다. 대상 및 방법 : 1991년부터 2003년 8월 사이에 서울 아산 병원에서 원발성 경화성 담관염으로 진단된 28명의 임상적, 혈청학적, 방사선학적, 조직학적 특징을 Backgroud : Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic hepatobiliary disease of unknown etiology, a characterized by inflammation, scarring and obliteration of bile ducts, eventually leading to biliary cirrhosis and liver fa