호흡곤란을 주소로 한 폐암환자의 한방치료 증례보고

손지영,최규호,유호정,김희준,구자환,박미연,최해윤,김종대,Son, Ji-Young,Choi, Gyu-Ho,Yoo, Hyo-Jeong,Kim, Hee-Jun,Goo, Ja-Whan,Park, Mee-Yeon,Choi, Hae-Yun,Kim, Jong-Dae 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.1

Object : This study was designed to evaluate the effects of oriental medicine therapy on a lung cancer patient. Methods : The patient was admitted on August 20. 2008 and remained until September 24. 2008. She was treated with herbal medicine. acupuncture and moxa therapy. Result & Conclusion : After the treatment. the symptoms and chest X-ray results improved. This result suggests that oriental medicine is an effective treatment for some lung cancer patients. Nevertheless more clinical case reports are needed.

귀비탕(歸脾湯)이 비소세포 폐암세포(NCI-H520) 이식 마우스에서 항암 및 면역 활성에 미치는 영향

손지영,최해윤,김종대,Son, Ji-Young,Choi, Hae-Yun,Kim, Jong-Dae 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4

Objectives : This study was to observe anticancer and related immunomodulatory effects of Kwibi-tang extracts (KBTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of KBTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, each of 8 mice per group were used in the present study. Changes in body weight, tumor volume and weight, lymphatic organs (spleen and popliteal lymph node), serum interferon (IFN)-${\gamma}$ levels, splenocytes NK cell activity and peritoneal macrophage activities, splenic tumor necrosis factor (TNF)-${\alpha}$, interleukin (IL)-$1{\beta}$ and IL-10 contents were observed with tumor mass and lymphatic organ histopathology to detect anticancer and immunomodulatory effects. The results were compared with a potent cytotoxic anticancer agent, 5-FU (5-Fluorouracil) 30 mg/kg, intraperitoneal treatment (3-day intervals for 42 days, the optimal effective treatment regimes already confirmed). Results & Conclusions : This study suggest that over 50 mg/kg of KBTe showed favorable anticancer effects on the NCI-H520 cell xenograft with immunomodulatory effects. Although relatively lower anticancer effects were observed in KBTe 200 mg/kg treated mice as compared with 5-FU 30 mg/kg treated mice, no meaningful favorable immunomodulatory effects were observed after 5-FU treatment in the present study.

귀비탕(歸脾湯)이 비소세포 폐암세포(NCI-H520) 이식 마우스에서 악액질 억제에 미치는 영향

손지영,김경순,최해윤,김종대,Son, Ji-young,Kim, Kyung-soon,Choi, Hae-Yun,Kim, Jong-Dae 대한암한의학회 2015 大韓癌韓醫學會誌 Vol.20 No.2

Purpose : The object of this study was to observe anti-cachexic effects of Kwibi-tang extracts (KBTe) on non-small cell lung carcinoma (squamous epithelial carcinoma), NCI-H520, xenograft Balb/c nu-nu nude mice. Methods : Three different dosages of KBTe, 50, 100 and 200 mg/kg were orally administered once a day for 42 days from 11 days after tumor cell inoculation. Six groups, each of 8 mice per group were used in the present study. Changes on the body weight, the epididymal fat weight and serum IL-6 levels were detected with the thicknesses of deposited cervical brown adipose tissue and their mean diameters to monitor the tumor-related anticachexic effects. Results : Deceases on the body weight and gains were also demonstrated in tumor-bearing control with increases of serum IL-6 levels, decreases of epididymal fat pad weight, atrophic changes of cervical brown adipose tissues. These are means that tumor-related cachexia are induced by tumor cell inoculations in the present study. However, these tumor-related cachexia were markedly inhibited by all three different dosages of KBTe treatment as compared with tumor-bearing control. 5-FU showed somewhat deteriorated the tumor-related cachexia in the present study. Conclusion : The results obtained in this study suggest that over 50 mg/kg of KBTe showed favorable anticachexic effects on the NCI-H520 cell xenograft. However, detail mechanism studies should be conducted in future with the screening of the biological active compounds in this herb.

도시 대기오염의 위해 평가에 있어서 황사효과 분석 -서울시 총사망 및 원인별 사망률에 미치는 영향-

손지영,조용성,김윤신,이종태,김연정,Son, Ji-Young,Cho, Yong-Sung,Kim, Yoon-Shin,Lee, Jong-Tae,Kim, Yeon-Jung 한국환경보건학회 2009 한국환경보건학회지 Vol.35 No.4

The objectives of this study were to compare the relative risk of all-cause mortality and cause-specific mortality associated with Asian dust events, and especially to investigate the effects on the susceptible population such as the elderly and children, which were based on the data in Seoul from 2000 to 2006. Both of the study periods with/without Asian dust days, respiratory-cause mortality was the highest, followed by cardiovascular-cause mortality and all-cause mortality in sequence among mortality related to air pollution for all-aged group. As to susceptible group, the relative risk of mortality is the highest for +65 yrs group among all-cause mortality. According to comparison of mortality with/without Asian dust days, the relative risk of all-cause mortality is larger in the model with Asian dust days than the one in the model without Asian dust days among all age group (except for under 15 yrs group) and all air pollutants. The relative risk of cause-specific mortality (except for ozone in under 15 yrs group in case of respiratory-cause mortality, and ozone in all age group and over 65 yrs group in case of cardiovascular-cause mortality) per IQR increase of each pollutant is larger in the model without Asian dust days.

Hemiballism-Hemichorea-Orofacial dyskinesia가 병발한 환자 치험 1례

손지영,윤효진,이성근,이병주,이기상,Son, Ji-Young,Yoon, Hyo-Jin,Lee, Seung-Geun,Lee, Byung-Ju,Lee, Key-Sang 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4

Objectives: This study was to examine diagnosis of dyskinesia by criteria of oriental medicine and to evaluate the effect of oriental medical treatment on the symptoms. Methods: After the patient was treated with Yonggyedeunggyo-tang, the changes in dyskinetic symptoms were evaluated for treatment efficacy every hospital day. Results: The dyskinesia symptoms disappeared. Conclusions: Herbal medicine and Saam Acupuncture therapy is useful for the treatment of Hemiballism- Hemichorea-Orofacial dyskinesia patients.

대상포진 후 신경통환자의 시령탕(柴領湯) 치험 1례

손지영,이성근,이기상,박준영,윤효진,Son, Ji-Young,Lee, Seong-Geun,Lee, Key-Sang,Park, Joon-Young,Yun, Hyo-Jin 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6

This study was designed to evaluate the effects of an oriental medicine(Siryung-tang) on pain caused by Post-herpetic neuralgia. We treated a 70 year-old male patient who suffered left flank pain by Post-herpetic neuralgia. As for treatment, we used Siryung-tang. After seven-day of treatment, all symptoms started to improved. This study suggests that Siryung-tang is effective in treatment of pain by Post-herpetic neuralgia.

편측성 후방연장 국소의치의 의치상에 이탈력이 가해질 때 간접유지장치가 장착된 치아 주위조직에 발생하는 응력에 관한 광탄성 분석

손지영,이청희,조광헌,Son, Jee-Young,Lee, Cheong-Hee,Jo, Kwang-Hun 대한치과보철학회 1996 대한치과보철학회지 Vol.34 No.3

하악좌측 제1대구치와 하악 좌측 제2대구치, 하악우측 제2소구치를 주지대치로 사용하고 하악우측 제1대구치와 하악 우측 제2대구치가 상실된 Kennedy 분류 II급 후방연장 국소의치에서 하악좌측 측절치에 incisal hook rest를 간접유지장치로 가지는 경운(Model I), 하악좌측 견치에 cingulum rest를 간접유지장치로 가지는 경우(Model II), 하악좌측 제1소구치에 근심교합면 레스트를 간접유지장치로 가지는 경우(Model III)의 모형에서, 상실된 하악우측제2대구치의 원심 변연융선에 해당하는 부위에 고리를 형성하여 교합평면에서 전상방 $45^{\circ}$ 각도로 860gm의 이탈력을 가하여 간접유지장치가 장착된 지대치와 양쪽 인접치 주위조직에 발생하는 응력을 비교분석한 바 다음과 같은 결론를 얻었다. 3가지 모형 모두에서 지대치의 치근단 부위보다는 치경부의 협측부위와 근원심 부위에 압축응력이 나타났다. 지대치의 설측 치경부에는 3가지 모형 모두에서 약한 인장응력이 나타났다. 협측부위의 압축응력의 크기는 Model I이 가장 컸고, Model II, Model III순으로 나타났다. Model I과 Model II에서 지대치의 근심과 원심 치경부에 압축응력이 나타났으며, 압축응력의 크기는 Model I이 Model II보다 더 컸다. Model III에서는 지대치의 근심치경부에서만 압축응력이 나타났다. 전반적으로 압축응력의 크기는 Model I이 가장 컸고, Model II, Model III의 순으로 나타났다. The purpose of this study was to evaluate the stress distributions in the surrounding tissues of the teeth seated by indirect retainers in three different teeth of unilateral distal extension partial denture when the dislodging forces were applied on denture bases. Three dimensional photoelastic models were made. The teeth on which indirect retainers were seated were mandibular left lateral incisor (Model I), canine (Model II), and first premolar (Model III). The dislodging force with 860mg at $45^{\circ}$ angulation to occlusal plane was applied to each model. Three dimensional photoelastic stress analysis was done, and the records were diagramed and analysed. The results were as follows : The compressive stresses were shown the most on neck portions of buccal, mesial, and distal sides in all three models. Slight tensile stresses were shown on neck portions of lingual sides in all three models. The compressive stresses on buccal side were shown in strength in such order as model I, model II, and model III. The compressive stresses were shown on neck portion of mesial and distal sides of model I and mode II, with model I more than Model II. The compressive stresses were shown only on neck portion of mesial side on Model III. The general overall magnitude of compressive stresses were shown in strength in such order as Model I, Model II, and Model III.

구강작열감 증후군 환자의 구강내 통증에 대한 한방치료의 효과: 전.후 비교 연구

손지영,김주연,강경,백승환,최제인,장승원,류봉하,김진성,Son, Ji-Young,Kim, Ju-Yeon,Kang, Kyung,Baek, Seung-Hwan,Choi, Jane,Jang, Seung-Won,Ryu, Bong-Ha,Kim, Jin-Sung 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.2

Objectives : Burning mouth syndrome (BMS) is characterized by chronic pain or a burning sensation in the mouth. There is limited evidence available to provide clear guidelines for treating BMS patients and a variety of different treatments have been used. This study was designed to investigate the Effects of Korean medicine therapies on oral pain in patients with BMS. Methods : We surveyed 30 BMS patients who newly visited the Oral Diseases Clinic in the Kyung Hee University Korean Medicine Hospital from February 2012 to March 2013. When the patients visited the clinic for the first time, they were evaluated on sociodemographic characteristics, BMS questionnaire, severity of pain using visual analogue scale (VAS) and pressure pain threshold (PPT) of the acupuncture point CV17. After 3 weeks of Korean medicine therapies (acupuncture, electroacupuncture, pharmacopuncture and herbal medicine), they were re-evaluated with the VAS and the PPT. Results : After 3 weeks of Korean medicine therapies, 30 patients' oral pain improved and the PPT score on CV17 rose, which means decrease of qi-stagnation score. Conclusions : Korean medicine therapies were effective on oral pain in patients with BMS. To confirm the additional curative effect and evaluate the efficacy of each treatment, well-designed randomized controlled trials will be needed in the future.

기능성 소화불량 환자에서 설태후박 및 흉늑각 측정의 진단적 가치

손지영,김진성,Son, Ji-Young,Kim, Jin-Sung 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.2

Objectives : The aims of this study were to evaluate the diagnostic values of tongue coating thickness and sterno-costal angle as the quantitative diagnostic indicators in functional dyspepsia. Methods : We surveyed 60 functional dyspepsia patients recruited by the clinical trial, 'Clinical Trial for Evaluation on Availability of tongue diagnosis system (CTS-1000) : a Pilot study'. The patients were classified into three groups according to Rome III criteria for functional dyspepsia, and categorized into five groups according to Instrument of pattern identification for functional dyspepsia. Nepean dyspepsia index-Korean version (NDI-K) score, tongue coating thickness (percentage of tongue coating by tongue diagnosis system (CTS-1000), and weight of tongue coating by microbalance), sterno-costal angle, duration of illness and body mass index (BMI) were investigated. Results : Among the 5 types by instrument of pattern identification for functional dyspepsia, a significant difference of percentage of tongue coating was found. Percentage of tongue coating and weight of tongue coating showed significant correlation with total NDI-K score. Sterno-costal angle showed strong positive correlation with BMI and also showed significant difference between the non-overweight (BMI<23, n=32) and overweight ($BMI{\geq}23$, n=28) groups. Conclusions : Tongue coating thickness showed its potential as a new quantitative diagnostic indicator of functional dyspepsia. Further studies on the sterno-costal angle are anticipated to evaluate its potential as a new quantitative diagnostic indicator.

시장 현황 및 전망

손지영,Son, Ji-Yeong 한국정보통신집흥협회 2005 정보화사회 Vol.173 No.-