방풍통성산(防風通聖散)이 아토피 피부염을 유발한 동물모델의 피부 손상에 미치는 영향

손정민,홍승욱,Son, Jung-Min,Hong, Seung-Ug 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objectives : Atopic dermatitis has a close relationship with damage of skin barrier function. To investigate the effects of Bangpungtongsungsan(BT) extract to the skin damage on mice model after atopic dermatitis elicitation, this study was done through forcing injury to mice's skin. Methods : The BALB/c mice were distributed into three groups: control(CON) group, atopic dermatitis(AD)-elicited group, Bangpungtongsungsan(BT)-treated group. AD-elicited and BT-treated group were caused AD according to the method of Christophers E., Mrowietz and Minehiro. The BT extract was administered for 48 hours to BT-treated group. We observed changes of external dermal formation, eosinophils in vasculature, lipid formation in stratum corneum, distribution of ceramide, distribution of capillary, $I{\kappa}B$ kinase(IKK) and induce nitric oxide synthase(iNOS) mRNA expression. We used the statistical methods of student t-test(p<0.05). Results : After dispensing BT extract into the AD-elicited group, the number of eosinophil as an atopic index in mice noticeably decreased and dermal injury decreased. Also the decrease of hyperplasia, degranulated mast cells, angiogenesis and substance P were shown. The lipid lamellae, lipid protect formation, were repaired and the distribution of ceramide which inhibit protein kinase C(PKC) activation increased, and the PKC caused inhibition of nuclear $factor(NF)-{\kappa}B$ activation. As a result of inhibition of $NF-{\kappa}B$ activation, iNOS production were inhibited and apoptotic cell were increased. Moreover the decrease of IKK and iNOS mRNA expression in BT-treated RAW 264.7 cell were noted. Conclusion : BT mitigated skin damage on mice model after atopic dermatitis elicitation through recovering skin barrier function and inhibiting nuclear $factor(NF)-{\kappa}B$ activation.

아토피 피부염에서 유전자 연구와 사상체질의학적 접근의 상관성에 관한 문헌적 고찰

손정민,최인화,Son, Jung-Min,Choi, In-Hwa 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.2

Objectives: The objective of this study is to investigate the correlation between genetic studies on atopic dermatitis. sasang constitution, and sasang constitional study on atopic dermatitis. Methods: We retrieved data on PubMed for the papers of genetic study on atopic dermatitis. And for the papers on genetic study of sasang constitution and sasang constitional study of atopic dermatitis, we referred to papers have reported on domestic medical journal and domestic korean medicine journal. And we investigated correlations among the studies. Results: 1. There are two studies on genetic study on atopic dermatitis. One has been performed to find out genes related to atopic dermatitis by case-control study. The other has been to investigate the correlation between atopic dermatitis and the genes their functions were well-known. 2. Gene study on sasang constitution was performed to observe the distribution of the genes which is related with characteristics of sasang constitution, but there was no significant maldistribution of the genes. 3. There was no correlation between genetic study on atopic dermatitis and genetic study on sasang constitution. Conclusion & Discussion: In the Sasang constitutional study of atopic dermatitis, it seems that further studies on genes related to characteristics of skin, character affecting on behavior, and neurobiological difference among Sasang constitution are required as well as studies on distribution of genes related atopic dermatitis.

PPAR-$\gamma$ 조절을 통한 여택통기탕(麗澤通氣湯)의 항알레르기와 항염증 효과

손정민,홍승욱,Son, Jung-Min,Hong, Seung-Ug 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.2

Objectives : The aim of this study is to investigate the antiallergic effects of YTT on allergic rhinitis by regulation of peroxisome proliferator-activated receptor gamma (PPAR-$\gamma$). Methods : The thirty rats were divided into three groups : normal group, control (allergic rhinitis elicited) group, sample (Yeotaectonggi-tang treated after allergic rhinitis elicitation) group. To induce allergic rhinitis in control group and sample group, rats were sensitized intraperitoneally with 0.1% ovalbumin(OVA) solution 3 times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin(OVA) solution 3 times at intervals of 2 days. After that time rats in sample group were oral administration treated by YTT for 7days. The change of the amounts of eosinophil, substance P, MIP-2, PPAR-$\gamma$, IL-4, iNOS were observed in each group. we used the statistical method of ANOVA test(p<0.05). Results : The number of eosinophil in sample group noticeably decreased than control group. And the decrease of substance P and MIP-2 positive reaction were observed in mucosa. YTT inhibited IL-4 and iNOS production, mucus secretion, activation of mast cells and fibrosis remodeling by regulation of PPAR-$\gamma$ activation. Conclusion : According to the above results, it is considered that YTT mitigated mucosa damage on the mice model with allergic rhinitis by regulation of PPAR-$\gamma$.

반도체 광증폭기의 상호 이득 변조를 이용한 2.5 Gbps 다채널 가변형 파장변환기

손정민,이상선,Son, Jung-Min,Lee, Sang-Sun 한국광학회 2005 한국광학회지 Vol.16 No.4

본 논문에서는 파장 분할 다중화 방식 광통신에의 적용을 목적으로 하는 다채널 가변형 파장 변환기(Wavelnength Convertor)를 구성하여 이의 성능을 분석하였다. 파장 변환기는 반도체 광증폭기(SOA : Semiconductor Optical Amplifier)의 상호 이득 변조(XGM : Cross Gain Modulation) 특성을 이용한 파장 변환 방식이 이용되었다. 2.5 Gbps 광통신 기반 100 CHz의 채널 간격을 갖는 다채널 신호들에 대한 파장 변환 성능을 측정, 분석하였다. 본 파장 변환기의 상호 이득 변조 성능을 측정한 결과, 소광비(Extinction Ratio)와 비트 오류율(BER : Bit Error Rate) 등의 검증에서 2.5 Gbps 기반의 파장 분할 다중화 방식 광통신에 사용하기에 충분한 성능을 보였으며, 이를 통해 최근 개발된 상호 위상 변조 방식(XPM Cross Phase Modulation)의 다채널 파장 변환기와 비교해 상대적으로 간단한 구조를 가지고 제작 및 변조 효율에 우위를 보이는 파장 변환기로서 대체될 수 있음을 밝힌다. A new structure of tunable wavelength converter based on XCM in SOA was tried and analyzed. This converter used single SOA and had very simple structure. In this paper, results were experimentally obtained and demonstrated. Pump signal was generated with NRZ $(PRBS\;2^{31}-1)$ and data rate 2.5 Gbps. WDM multi conveted signals showed more than 8.3 dB extinction ratio. For BER performance, all these converted signals had within 5.0 dB power penalty compared with the pump signal. With these results, we showed that this converter was suitable for 2.5 Gbps WDM multi-channel wavelength converting.

외국인 비용이 기업특유우위와 성과간의 관계에 미치는 효과

손정민(Jung Min Son),박영렬(Young Ryeol Park) 한국경영학회 2008 經營學硏究 Vol.37 No.6

This study investigates firstly the moderating effects of the liability of foreignness of foreign-invested firm on the relation between its firm-specific advantages (FSAs) and performance in Korea, and secondly how these moderating effects differ depending on the types of FSAs. It begins with the assumption that the liability of foreignness hinders exploitation of FSAs in a host country. Embeddedness, legitimacy, and strategy of foreign-invested firms are employed as moderating factors since these directly increase or reduce the level of liability of foreignness as asserted in previous related studies. The FSAs are classified into globally applicable FSAs and locally applicable FSAs depending on limitation on locational application. Data with 139 foreign-invested firms in Korea was tested. The major empirical results are summarized as follows. First, embeddedness positively moderates the relationship between locally applicable FSAs and firm performance. This result shows that foreign-invested firms can overcome the liability of foreignness by exploiting locally applicable FSAs when they are embedded in a host country network, and even improve their performance. Second, legitimacy of foreign-invested firms does not influence on the liability of foreignness. Market globalization has weakened boundaries between foreign and national firms thus, legitimacy is not questioned for foreign-invested firms to remove discrimination against foreign firms. Third, as expected global strategy facilitates the exploitation of foreign-invested firms` globally applicable FSAs.

추천은 고객 유지에 항상 영향을 주는가?

손정민(Son, Jung Min) 한국서비스경영학회 2015 서비스경영학회지 Vol.16 No.2

Recommendation gives an important impact on consumer’s decision making. At that time, consumers" personal mindsets and environmental factors play a role to determine the effect of recommendation. This study intended to observe which role such surrounding factors were playing in the situation of recommendation. The purpose of this study was, firstly, to compare the effect of the recommendation from the friends and family with the effect of recommendation from media, who had a difference of social distance, and secondly to verify the congruency effect between social distance and temporal distance based on the construal level theory. Thirdly, it intended to verify the congruence of socio-temporal distance to be controlled by cultural background, the external factor (i.e., individualism culture and collectivism culture)and the internal factor (i.e., consumer’s involvement). While the existing studies on the effect of congruence have overlooked the role of external factors, this study would complement the limit of such studies. Hence, the studies on the construal level theory for the effect of congruence and the studies on involvement and culture were examined, and a relevant hypothesis was produced. In order to attain such goal, this study intended to explain the effect of the difference measured by cultural background with the consumer’s survey data collected in the United States, Japan and China.

Au wire와 Al pad사이의 IMC(Intermetallic Compound) 형성에 의한 수명예측

손정민(Jung-Min Son),장미순(Mi-Soon Chang),곽계달(Kae-Dal Kwack) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11

During the manufacturing and the service life of Au?Al wire bonded electronic packages, the ball bonds experience elevated temperatures and hence accelerated thermal diffusion reactions that promote the transformation of the Au?Al phases and the IMC growth. In this paper, the IC under high temperature storage (HTS) tests at 175℃, 200℃, and 250℃ are meticulously investigated. Thermal exposure resulted in the IMC growth, Kirkendall void and the crack of the Au?Al phases. The crack propagation occurs resulting in the failure of the Au?Al ball bonds. As the IC was exposed at the high temperature, decreased in the lifetime.

SAD 알고리즘을 이용한 소형표적 검출속도 개선

손정민(Jung-Min Son),안상호(Sang-Ho Ahn),김종호(Jong-Ho Kim),김상균(Sang-Kyoon Kim) 한국산업정보학회 2013 한국산업정보학회논문지 Vol.18 No.4

본 논문에서는 소형표적의 검출속도를 개선하기 위하여, SAD 알고리즘을 이용한 소형 표적 검출 방법을 제안한다. 먼저 미디언 필터를 사용해서 클러터를 제거한다. 다음으로 다양한 크기의 구조 요소를 이용해 닫힘 연산과 열림 연산을 수행하고, 닫힘 연산 결과와 열림 연산 결과를 차 연산 하여 표적 후보 화소를 추출한다. 정확한 소형 표적을 검출하기 위해 표적 후보 영역에서 가우시안 거리 함수를 이용하여 표적을 검출한다. 검출 속도를 개선하기 위하여 다음 7프레임에서는 표적의 방향성을 예측한 후, SAD알고리즘을 이용해서 표적을 검출한다. 제안한 방법은 예측된 영역에서만 표적을 추출함으로써 97%의 검출율을 나타내며, 실시간 처리가 가능한 장점을 가지고 있다. We propose a method for improving detection speed of small target detection system using SAD algorithm. First, the proposed method deletes clutters using a median filter. Next, it does closing and opening operation using various size of structure elements, and extracts candidate pixels for a target with subtraction operation between the results of closing and opening operation. It finally detects a small target using a gaussian distance function from the candidate pixels. To improve detection speed, it detects a target performing SAD algorithm only for the predicted target areas for next every 7 frames. The proposed method not only enables a real time process because it considers only predicted area but also shows detecting rate of 97%.

신질환을 가진 환자에서 임신이 산모와 태아에 미치는 영향

손정민 ( Jung Min Son ),김정희 ( Jung Hee Kim ),정우진 ( Woo Jin Jeong ),최영진 ( Young Jin Choi ),권은회 ( Eun Hoe Kwon ),정유석 ( You Seok Jeong ),이동원 ( Dong Won Lee ),이수봉 ( Soo Bong Lee ),곽임수 ( Ihm Soo Kwak ) 대한내과학회 2005 대한내과학회지 Vol.68 No.2

목적 : 신질환을 가진 환자에서 임신시 태아 사망률이 증가하고 산모의 신기능이 악화된다고 알려져 있다. 이에 저자들은 신질환을 가진 환자에서 임신이 태아와 산모에 미치는 영향을 알아보고 불량한 임신 성적과 연관된 인자를 분석하고자 하였다. 또한 분만 후 가역성 여부 및 이와 연관된 인자를 알아보고자 하였다. 방법 : 1993년 1월부터 2002년 12월까지 부산대학교 병원에서 임신 전 또는 분만 후 6개월 이내에 조직 검사를 통해 신질환을 진단받은 26 Background : Chronic kidney disease has deleterious influences on pregnancy, both fetus and mother. To determine the pregnancy outcome and associated risk factors, we analyzed 36 pregnancies in 26 women with various chronic kidney diseases. Methods : Retr

서비스 청사진을 이용한 약국의 서비스 프로세스 혁신

손정민(Son, Jung Min),유해원(Yoo, Hai Won) 한국서비스경영학회 2016 서비스경영학회지 Vol.17 No.2

Service innovation refers to new or considerably changed service processes that deliver added value to the customers. Unfortunately, many of the activities are invisible to both service providers and consumers. In terms of service innovation, service visualization is very critical. When we visualize the current service process, we can identify its problems. So, this study suggests to innovate service processes by analyzing service blue print of pharmacies and take corrective action. Korean pharmacies are facing both internal and external challenges to overcome. This study is especially to focus on process aspects of pharmacies and present effective solutions by diagraming service processes based on service blue print. After the visualization processes, we did interviews. Interviews were conducted on person in charge at Onnuri pharmacy chain and pharmacists. As a result, it showed lack of supporting processes on medication management and product inventory management. Limited display shelves fails to hold various range of products. Lack of medication counseling time led patient dissatisfaction. In conclusion, we are to present amended processes and alternatives to make improvements. Differentiation strategy should be designed by implementing new service processes.