흰쥐에서 Vitamin A 의 장기 투여가 혈중 및 간조직의 각종 지질 분획에 미치는 영향

김인주(In Joo Kim),손재경(Jae Kyung Sohn),정상립(Sang Lip Chung),김정철(Jung Chul Kim),정태호(Tae Ho Chung) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.6

This study was carried out to determine the effect of long term administration of vitamin A on the changes of lipids in liver tissue and serum in rat. The animals were fed with control diet(200 ug/day) and high vitimin A diet(2, 000 ug/day) for 24 weeks. Vitamin A contents of liver in high vitamin A fed rats were increased linearly accordance with duration of the vitamin A administration, but levels of serum vitamin A showed unremarkable changes during the experimental period. Contents of cholesterol and triglycerides of vitarnin A fed rats were significantly higher than those of controls. Levels of HDL-triglycerides in v:itamin A fed rats were significantly higher than those of control rats during experimental period, while levels of HDL-cholesterol and HDL-phospholipids showed unremarkable changes during experimental period. Levels of individual cholesteryl esters showed undremarkable changes during experimental period in both animal groups.

노인층의 조갑진균증에 대한 연구

손재경,이시헌 대한의진균학회 2001 대한의진균학회지 Vol.6 No.2

Background: Onychomycosis is a common disease and has a tendency to increase in its incidence. Although there have been many reports about onychomycosis, very few studies about onychomycosis in the elderly have yet been conducted. Objective: The purpose of this study was to investigate the clinical and mycological features of onychomycosis in the elderly, and to evaluate the concept and attitude of the elder patients towards onychomycosis, which would affect the treatment and further infections of onychomycosis. Method: Sixty eight onychomycosis patients over 60 years old were examined clinically and surveyed by questionnaire to evaluate their concern about the onychomycosis. All the patients were confined by potassium hydroxide (KOH) examinations and underwent cultures on the both cornmeal potato agar with and without cycloheximide. An additional culture was done a week later when the intial culture showed contamination or no growth. Results: Among 648 patients with onychomycosis, 68 patients (10.5%) were over 60 years old. Fifty(73.5%) were female and 18 (26.5%) ware male. Twenty six (38.2%) had systemic illness. The average duration of onychomycosis was 13 years and the average number of onychomycosis involving nails was 4.7. Sixty three patients (92.6%) had toe nail onychomycosis. Sixty six patients (97.1%) showed distal subungal onychomycosis. Trichophyton rubrun was the main causative organism in 38 patients (55.9%). Forty one patients (60.3%) discontinued the medication in 4 weeks, and 11 (16.2) were treated over 12 weeks. From the questionnaire, only 10 patients reported previous treatment far this problem, but with duration of treatment no longer than one month. Fifty three patients had mere understanding atypical alternation in their nails before the visit. The main reasons of the discontinuing the medication were the cost of the treatment, physical discomfort due to age, and extended duration of the therapy. Conclusion: From this study, we noticed that the elder onychomycosis patients could be long time carriers of fungi because of their lack of the knowledge of onychomycosis and insufficient treatment. Therefore, it is necessary to deucate and support to treat the elder patients effectively. [Kor J Med Mycol 6(2): 77-83]

赤血球膜의 Cholesterol含量 變動이 補體溶血에 미치는 效果

孫在卿,金麗姬,鄭泰浩 慶北大學校 醫科大學 1985 慶北醫大誌 Vol.26 No.3

세포막의 지질변동은 그세포를 표적으로 하는 세포상해 반응에 큰 영향을 줄수있다는 보고에 따라 본연구에서는 사람 정상적혈구막의 cholesterol 함량을 변동시켜 mouse antihuman hemolysin과 rabbit complement에 의한 용혈 정도를 측정하였다. 적혈구를 cholesterol로 처리한 cholesterol-enriched군의 적혈구막의 C/P molar ratio는 1.52±0.11으로 대조군의 0.82±0.08에 비해 유의성 있게 증가된 반면, 적혈구를 phosphatidylcholine으로 처리한 cholesterol-depleted군의 혈구막의 C/P molar ratio는 0.58±0.05으로 대조군에 비해 유의성 있게 감소되었다. 한편 mouse antihuman hemolysin과 가토보체를 적혈구와 반응 시켰을때 적혈구를 50% 용혈시키는 보체농도의 평균치는 cholesterol-enriched 군에서는 0.047±0.048㎖로 대조군의 0.09±0.047㎖보다 유의성있게 낮았으며, cholesterol-depleted 군에서는 0.117±0.055㎖로 대조군보다 유의성있는 높은 치를 나타내었다. 즉 적혈구막의 cholesterol함량이 높을수록 보체용혈에 대한 적혈구의 감수성이 높음을 나타내었다. The membrane lipid fluidity of normal human erythrocytes was modified by enrichment and depletion in cholesterol, and the expression of surface antigens was assayed by complement hemolysis test. Human erythrocytes, sensitized by specific mouse antihuman hemolysin, showed a significant increase in susceptibility to complement lysis after rigidification of the membrane lipid layer by incorporation of cholesterol. Conversely, fluidization of the membrane lipid layer by treatment with phosphatidylcholine for cholesterol depletion displayed increased tolerance to the complement lysis.

삼첨판 폐쇄부전 환자에 동반된 반응성 천공성 교원증 1예

김상원,손재경,이시헌 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.10

Reactive perforating collagenosis(RPC) is a kind of perforating disorder characterized by the transepidermal elimination of altered dermal collagen. Two types have been recognized; the childhood or inherited form and the adult or acquired form. Acquired RPC is frequently associated with diabetes, chronic renal failure with nephropathy and liver disease. We describe a case of RPC in a 41-year-old woman of about 2 months' duration. She has had a problem of tricuspid regurgitation for 3 years. Skin lesions showed scattered umbilicated papules with central keratotic plugs, 0.3-0.8cm sized, located on the proximal extremities.

다발전이한 (多發轉移한) 결절형 악석흑색종의 임상 및 분검소견

김태순,김상원,하용마,손재경,문세광 대한피부과학회 1982 大韓皮膚科學會誌 Vol.20 No.2

We have experienced a 50-year-old male patient, who died of multiple metastatic nodular melanoma which had the primary lesions on the right hallux and forefoot with eventual involvement of skin and internal organs. An autopsy was performed for the evidence of metastatic features of the internal organs and their spreading routes, with concurrent histopathologic findings. The autopsy findings revealed diffuse metastases to the ipsilateral femoral and inguinal lymph nodes via ascending vascular channels and to the internal organs: 1. The heart had multiple metastatic lesions on the pericardium and right ventricular wall. And the mediastinal, periaortic and periesophageal lymph nodes were also involved. 2. The both lungs were moderately indurated and focally discolored, and showed metastatic lesions in the right lower lobe and hilar areas, Melanoma cells were diffusely invaded to the interstitia and alveoli. 3. The right 5th and 6th ribs showed the invsion of melanoma cells on their bone marrows, periostia, and Haversians canals. 4. The liver was enlarged and showed multiple various sized nodules on the surface with adesion to the parts of peritoneum, omentum and diaphragm. Melanoma cells were seen mostly on and around the sinusoidal spaces and parenchyma. 5. The stomach wall had an ulcerated metastatic lesion and the melanoma cells invaded deeply into the muscle layer. 6. The pancreas was normal in its size and shape but had multiple metastatic lesions on the head and body with melanoma celi infiltration. 7. The both kidneys were grar ular surfaced and showed two metastatic lesions on the right renal cortex and two on the left. Renal tubules and parenchyma were widely invaded by melanoma cells but the glomerular tufts were intact. 8. The adreral and thyroid glands showed four and two metastatic lesions respectively and diffuse invasion of melanoma cells into the parenchyma. 9. The brain was normal in gross appearance, but the cortex was edematous and showed settered melanoma cell infiltration.