저산소-재산소화 손상에 미치는 Nitric Oxide에 대한 항산화제의 상호작용

손영길(Young Gil Son),김광일(Kwang Il Kim),조해창(Hae Chang Jo),이정안(Jung Ahn Rhee),배병조(Byung Jo Bae),최형철(Hyung Chul Choi),이광윤(Kwang Yoon Lee),김원준(Won Jun Kim) 대한외과학회 2003 Annals of Surgical Treatment and Research(ASRT) Vol.64 No.4

점막하 위암에서 림프절 전이 예측 인자에 대한 연구

손영길(Young Gil Son),류승완(Seung Wan Ryu),김인호(In Ho Kim),손수상(Soo Sang Sohn),강유나(Yu Na Kang) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.6

Purpose: Lymph node metastasis is an important prognostic factor in patients with early gastric cancer. Therefore, we analyzed the predictive factors for lymph node metastasis in submucosal gastric cancer and explored the feasibility of minimally invasive surgery. Methods: The clinicopathological features of 317 patients with submucosal gastric cancer, who underwent radical gastrectomy with lymph node dissection at Department of Surgery, Keimyung University School of Medicine from January 2003 to December 2007, were examined retrospectively. The lesions were divided into 3 layers according to the depth of submucosal invasion of the cancer cell (SM1, SM2, and SM3). We analyzed the clinicopathological variables regarding lymph node metastasis. Results: Of the 317 patients, 74 patients (23.3%) had lymph node metastasis. Tumor size, histological type, Lauren classification, depth of invasion, lymphatic invasion, vascular invasion, and perineural invasion showed a positive correlation with lymph node metastasis by univariate analysis. In multivariate analysis, tumor size (≥4 cm vs <2 cm, P=0.034 and 2∼4 cm vs <2 cm, P=0.043), histological type (P=0.013), and lymphatic invasion (P=0.000) were significantly correlated with lymph node metastasis. Conclusion: Tumor size, histological type, and lymphatic invasion were independent risk factors for lymph node metastasis in submucosal gastric cancer. Minimally invasive surgery, such as endoscopic submucosal dissection may be applied to submucosal gastric cancer with a tumor size less than 2 cm, differentiated histological type, and no lymphatic invasion.

노인위암 환자에서 위 절제술 후 합병증 발생 예측 인자로서의 Geriatric Nutritional Risk Index와 체중감소율의 유용성

이경은 ( Kyung Eun Lee ),손영길 ( Young Gil Son ),류승완 ( Seung Wan Ryu ) 한국정맥경장영양학회 2014 한국정맥경장영양학회지 Vol.6 No.1

Purpose: Gastric cancer surgery is expected to increase in frequency in elderly patients aged over 65 years. The aim of this study was to validate the Geriatric Nutritional Risk Index (GNRI) and percent weight loss as a predictor of post operative complications after gastrectomy in elderly patients. Methods: We retrospectively collected data on elderly patients (over 65 years) who underwent gastrectomy for gastric cancer at Keimyung University Dongsan Medical Center between January 2010 and December 2012. Data included patients characteristics (body mass index [BMI], underlying disease, body weight loss during 3 months before gastrectomy, American Society of Anesthesiologists [ASA] score, and stage of disease), operative characteristics (operation method, operation time, and blood loss during operation), GNRI, and post-operative complications after gastrectomy. Results: A total of 321 patients were included. The patients`mean age was 72.4±4.7 years, and 49.5% of patients were rated as being at risk by the GNRI. There were no differences in post-operative complications by GNRI, age, sex, ASA score, BMI, serum albumin, co-morbidity, stage of disease, surgical approach, type of surgery, extent of lymph node dissection, operation time, or blood loss during surgery. However, percent weight loss during 3 months was correlated independently with post-operative complications (P<0.001). In logistic regression analysis, a 1% increase in percent weight loss was associated with a 1.102 times increase in the incidence of postoperative complications (P=0.012, 95% confidence interval 1.021~1.189). Conclusion: The percent weight loss during 3 months before gastrectomy could help predict post-operative complications in elderly patients.

위암 환자의 위절제술 후 삶의 질 국내 연구 동향

이경은(Lee, Kyung Eun),손영길(Son, Young Gil) 대한종양간호학회 2016 Asian Oncology Nursing Vol.16 No.2

Purpose: The aim of this study was to analyze the research trends of quality of life (QOL) after gastrectomy among gastric cancer patients in Korea and to make suggestions for future studies. Methods: A literature search was done using Pubmed, CINHAL, and Korean databases in Korean and English. Results: A total of 53 studies from 1993 to 2015 were analyzed. Of 53 papers, 6 (11.3%) were doctoral dissertations and master’s theses, and 47 (88.7%) were from academic journals. All of the studies (100%) used quantitative research designs. The European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ)-C30 and EORTC QLQ-STO22 were mostly used to evaluate QOL in the studies. The main research issues were varied, in particular, the most common subjects of studies were QOL related to the evaluation of treatment methods. Conclusion: Further studies about QOL after gastrectomy with gastric cancer patients need to be done with various approaches such as intervention studies to improve QOL, qualitative studies, and multidisciplinary research.

장관 손상으로 확진된 범발성 복막염에 대한 임상적 고찰

조해창,전성윤,배병조,유동걸,손영길,이정안 대한외상학회 2001 大韓外傷學會誌 Vol.14 No.1

Background: Generalized peritonitis in abdominal trauma patients is a common disease entity. An injury of the hollow viscera is the major cause of traumatic generalized peritonitis, so it is necessary to study clinical analysis of traumatic generalized peritonitis caused by hollow visceral injury. The aim of this study is to help early diagnosis and appropriate treatment by evaluating patients with traumatic generalized peritonitis. Materials and Methods: We evaluated 76 patients with generalized peritonitis caused by hollow visceral injury after abdominal trauma who had undergone a laparotomy in the Department of General Surgery, Daegu Fatima hospital, from January 1996 to December 2000. The authors reviewed their medical and operation records retrospectively. Results: The results are as follows: 1) The most common ages were in the 3rd, 4th, 5th, and 6th decades (82.9%). There were 59 males and 17 females (M : F=3.5 : 1). 2) the generalized peritonitis caused by hollow visceral injury after abdominal trauma was due to blunt trauma in 45 (59.2%) patients and penetrating trauma in 16 (21.1%) patients. The most common injured organ was the small bowel (53 patients, 69.7%). 3) The most common symptom and sign were abdominal pain (89.4%) and abdominal tenderness (93.4%), followed by rebound tenderness, abdominal distension, and wound pain. 4) There was a leukocytosis in 54 (71.1%) patients. 5) Abdominal CT (72.3%) and simple abdomen (65.8%) was performed for appropriate diagnosis. 6) Sixty-three (63) patients (82.9%) were operated on within 12 hours from injury. 7) The incidence of blood transfusion was more common in penetrating trauma (56.3%). 8) GIT perforation alone occurred in 34 (44.7%) patients. 9) Except for the hollow visceral organ, the most common associated intraabdominal injured organ and extraabdominal injured organ were the mesentery and the pelvis, respectively. 10) The primary repair in 48 (63.2%) patients more commonly involved hollow visceral injury. 11) The most common complications were infection and retension abscess which in 4 (5.3%) patients each. 12) The mortality rate was 3 (3.9%) patients, and the cause of injury in those case, was blunt trauma. Conclusion: We suggest that early diagnosis and speedy transfer are needed in traumatic generalized peritonitis patients. According to the surgical indication, operative treatment should occur as soon as possible to reduce morbidity and mortality in such patients.