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윤설영 ( Yun Seol Yeong ),이은주 ( Lee Eun Ju ),허정훈 ( Heo Jeong Hun ),손영기 ( Son Yeong Gi ),한경근 ( Han Gyeong Geun ),안원석 ( An Won Seog ),김성은 ( Kim Seong Eun ),김기현 ( Kim Gi Hyeon ) 대한내과학회 2004 대한내과학회지 Vol.66 No.2
목적 : 특발성 막성신병증은 신증후군을 주 증상으로 하는 질환으로 자연관해에서부터 만성신부전증으로 진행하는 다양한 임상상을 나타낸다고 알려져 있다. 본 질환의 다양한 임상경과에 관하여 분석함과 아울러 신증후군의 치료법으로 사용하고 있는 steroid 단독요법과 chlo-rambucil 병합요법의 효과를 평가하고자 하였다. 방법 : 1990년 3월부터 2003년 8월까지 동아대학교병원 내과에서 진료 받고 신생검으로 진단된 특발성 막성신병증 환자 중 2년 Background : Idiopathic membranous nephropathy (IMN) causes variable clinical courses, such as from asymptomatic urinary abnormalities, nephrotic syndrome to end-stage renal failure. We evaluated clinical findings and effects of steroid and steroid with c
간세포성 암종과 담관암종에서 Glutathione S - Transferase π의 면역조직화학적 발현
박희승,한상영,최홍조,손영기,최석렬,이종훈,노명환,허기영 대한소화기학회 1998 대한소화기학회지 Vol.31 No.1
Background/Aims: It has been known that glutathione S-transferase π (GST-π) is overexpressed in chemically induced precancerous or cancerous lesions of the hepatocyte in animal models. Unlike most results of animal models, however, there has been a controversy concerning the applica!ion of GST-π to human liver cancer as a tumor marker. Therefore, this study was carried out to evaluate the expression and the possibility of GST-π as an immunohistochemical marker in human hepatocellular carcinoma and cholangiocarcinoma. Methods: Labeled streptavidin biotin method after heat pretreatment with microwave oven was performed in formalin-fixed, paraffin-embedded tissue taken from wedge or needle biopsies from 16 cases of normal liver tissue, 20 hepatocellular carcinoma, and 20 cholangiocarcinoma, respectively. Results: The overexpression of GST-π was found in only three (15%) of 20 cases of hepatocellular carcinoma, but in sixteen (80%) of 20 cases of cholangiocarcinoma. The expression of GST-π in hepatocellular carcinoma showed a tendency to be increased with lower histology grade, but that in cholangiocarcinoma revealed a tendency to be decreased with lower histologic grade. Conclusions: The results suggested that expression of GST-π would be an immunohistochemical marker of human cholangiocarcinoma, rather than hepatocellular carcinoma, unlike the results of GST-π expression during chemically induced animal hepatocarcinogenesis.