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소혜민,엄희정,이다혜,김실,강기성,이일균,백관혁,박준언,김기현 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.8
Identification of bioactive natural products withanticancer activity as well as alleviating effects onchemotherapy-induced side effects has significant implicationsfor cancer treatment. Betula platyphylla var. japonica, commonly known as Asian white birch, has beenused in Chinese traditional medicine for a variety of purposes. In this study, the medicinal properties of betulinfrom B. platyphylla var. japonica useful for cancer managementwere investigated. LC/MS analysis revealed thatbetulin is a main chemical component of the EtOH extractof B. platyphylla var. japonica bark, and betulin was isolatedfrom EtOH extract using an LC/MS-guided isolationmethod. Its structure was identified with 1H and 13C NMRspectroscopic data and LC/MS analysis and then comparedto the previously reported spectroscopic and physical data. We first verified the cytotoxicity of betulin against threehuman lung adenocarcinoma cell lines, A549, H1264, andCalu-6, with IC50 values ranging from 18.7 to 39.6 lM. Regarding alleviation of side effects associated with anticancerchemotherapy, betulin ameliorated cisplatin-inducedrenal cell damage to 80% of the control value fromthe concentration of 5 lM. In addition, betulin showedanti-gastritis activity against ethanol-induced gastric damagein rats and notably reduced the gastric damage indexcompared to control in a concentration-dependent manner. These findings provide the first experimental evidence forpotential use of B. platyphylla var. japonica as a functionalfood for cancer treatment that simultaneously alleviates theside effects of chemotherapy.
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백수철,최은용,엄희정,조문석,김실,소혜민,김선희,강기성,김기현 한국생약학회 2018 Natural Product Sciences Vol.24 No.4
Betula platyphylla var. japonica (Betulaceae), also known as Asian white birch, is an endemic medicinal tree, the bark of which has been used in Chinese traditional medicine for the treatment of various inflammatory diseases. In our continuing search for bioactive compounds from Korean natural resources, a phytochemical investigation of the bark of B. platyphylla var. japonica led to the isolation of 7-oxo-b-sitosterol (1) and soyacerebroside I (2) from its ethanol extract as main components by liquid chromatography (LC)/mass spectrometry (MS)-based analysis. The structures of isolates were identified by comparison of 1H and 13C nuclear magnetic resonance spectroscopic data and physical data with the previously reported values and LC/MS analyses. To the best of our knowledge, this is the first study to demonstrate that the isolated compounds, 7-oxo-b-sitosterol and soyacerebroside I, were isolated in B. platyphylla var. japonica. We examined the effects of the isolates on the regulation of adipocytes and osteoblast differentiation. These isolates (1 and 2) produced fewer lipid droplets compared to the untreated negative control in Oil Red O staining of the mouse mesenchymal stem cell line without altering the amount of alkaline phosphatase staining. The results demonstrated that both compounds showed marginal inhibitory effects on adipocyte differentiation but did not affect osteoblast differentiation.
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