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3-NP에 의해 유발된 신경교세포의 산화적 손상에 대한 남성(南星)의 보호효과
이정섭,신용진,전지영,설재균,최철원,신선호,이인,남상규,Lee, Jung-Sup,Shin, Yong-Jin,Jeon, Ji-Young,Seol, Jae-Gyun,Choi, Chul-Won,Shin, Sun-Ho,Lee, In,Nam, Sang-Kyu 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3
Objectives : This study aimed to investigate the underlying protective mechanism of Rhizoma Arisaematis(RA) on 3-NP-induced Cytotoxicity in rat C6 glial cells. Methods : We investigated treatment ofC6 cells with 20mM 3-NP and pretreatment with RA to cause loss of cell viability. and morphological change. which was associated with elevation of ROS level. increase in Bax/Bcl2 ratio and HIF-a protein expression Results : RA inhibited 3-NP-induced cell death in C6 glial cells and inhibited the changes of the : MMPT (mitochondria membrane potential transition) and inhibited the decrease of mitochondria complex II activity and 3-NP-induced ROS generation in C6 cells. And RA decreased the activity of HIF-a and Bax. and increased the activity of $Bcl_2$ in C6 glial cells Conclusions : RA markedly protects C6 glial cells from 3-NP-induced oxidative injury.