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남성 음주자에서 안면 홍조 유무에 따른 음주량과 비만과의 관계
서원윤,김성수,김종성,윤석준,백서채,양준석 대한비만학회 2015 The Korean journal of obesity Vol.24 No.4
배경: 이 연구의 목적은 남성에서 안면 홍조 유무에 따른 음주량과 비만의 위험을 평가하는 것이다. 방법: 모 대학교병원 종합건강증진센터에 내원한 1,198명의 남성을 대상으로 하였다. 면담과 설문지를 통하여 음주량, 음주할 때 안면 홍조 발생, 흡연 상태, 운동량을 평가하였다. 음주량에 따라 비음주군(대조군), 저적정음주군(주 7잔 이하), 고적정음주군(주 7잔 초과 14잔 이하), 과음군(주 14잔 초과)으로 구분하고, 안면 홍조 여부에 따라 비홍조군 및 홍조군으로 구분하였다. 비만의 진단기준은 체질량지수 25 kg/m2 이상, 복부비만의 기준은 허리둘레 90 cm 이상으로 하였다. 연령, 흡연 상태, 운동량을 보정한 후 로지스틱 회귀분석을 하여 비만의 위험을 평가하였다. 결과: 비홍조군에서 비음주군에 대한 저적정음주군과 고적정음주군의 비만과 복부비만에 대한 교차비는 유의하게 증가하지 않았다. 그러나 비홍조군에서 비음주군에 대한 과음군의 비만과 복부비만에 대한 교차비는 각각 1.55 (95% CI, 1.01-2.40), 1.63 (95% CI, 1.02-2.58)으로 유의하게 증가하였다. 홍조군에서 비음주군에 대한 저적정음주군의 비만과 복부비만에 대한 교차비는 유의하게 증가하지 않았다. 그러나 홍조군에서 비음주군에 대한 고적정음주군과 과음군의 비만에 대한 교차비는 각각 2.10 (95% CI, 1.07-4.16), 2.16 (95% CI, 1.08-4.34), 복부비만에 대한 교차비는 각각 2.06 (95% CI, 1.05-4.06), 2.50 (95% CI, 1.26-4.98)으로 유의하게 증가하였다. 결론: 비홍조군에서 주 14잔을 초과하는 음주군은 비만의 위험이 비음주군보다 증가하지만, 홍조군에서는 주 7잔을 초과하는 음주군에서도 비만이 위험이 증가할 수 있다.
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이채진,김성수,서원윤,김종성,정진규,윤석준,서유리,양현정 대한골대사학회 2019 대한골대사학회지 Vol.26 No.3
Background: Despite daily vitamin D recommendations, women with osteoporosis may not achieve optimal 25-hydroxy-vitamin D (25[OH]D) levels. We retrospectively evaluated the effect of education and vitamin D supplementation (1,000 IU/day) in Korean women with osteoporosis. Methods: Sixty-one women with osteoporosis who were taking cholecalciferol (800-1,000 IU/day) were enrolled during 2011 to 2012. Forty patients (education only, Edu group) were educated on the importance of >30 min sunlight exposure daily while taking vitamin D. Twenty-one patients (education with vitamin D supplementation, Add group) were prescribed 1,000 IU/day cholecalciferol (total 1,800-2,000 IU/day) plus education. Patients were divided into 3 groups according to serum 25(OH)D status: deficiency (<20 ng/mL), insufficiency (20-30 ng/mL), and sufficiency (≥30 ng/mL). Furthermore, 25(OH)D levels were compared at baseline and after intervention for 3 months. Results: The median (interquartile range) serum 25(OH)D concentration at baseline was 25.10 (18.95-33.60) ng/mL. The mean (±standard error) differences in 25(OH)D levels from baseline to post-intervention were 19.85±3.86 and 31.73±4.82 ng/mL in the Edu group and Add group, respectively. Eighteen patients (29.5%) had vitamin D deficiency, 25 (41.0%) had insufficiency, and 18 (29.5%) had sufficient levels. Optimal 25(OH)D (30 ng/mL or more) was achieved in 54.5% and 95.2% patients in the Edu group and Add group, respectively (P=0.003). Conclusions: We consider that vitamin D concentration should be measured on a regular basis in order to maintain an optimal level of vitamin D concentration, and education and supplementation is needed if not sufficient.
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Drinking Amount Associated with Abnormal Gamma-Glutamyl Transpeptidase Expression in Women
Jun-Seok Yang,김종성,서원윤,Sir-Chae Paik 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.1
Background: This study investigated whether there is any difference in drinking amount associated with abnormal expression of gamma-glutamyl transpeptidase (GGT), one of the biological markers of excessive drinking, between flushing and non-flushing women after drinking Methods: The subjects were 797 women aged 20–59 years old who visited health promotion center of Chungnam National University Hospital between January, 2013 and July, 2014. Facial flushing status after drinking, amount of alcohol consumed per drinking episode, and the number of drinking days per week were assessed using a questionnaire. Age, abnormal GGT expression, smoking status, menopauase status, and body mass index (BMI) were obtained from the health screening data. The weekly drinking amount were categorized into <4 drinks; ≥4, <8 drinks; and ≥8 drinks. The association of abnormal GGT expression with weekly drinking amount was analyzed using multivariate logistic regression after controlling for confounding variables including age, smoking status, menopauase status, and BMI. Results: Compared to nondrinkers, the abnormal GGT expression in the non-flushing group was significantly increased when the weekly drinking amount was ≥4 drinks (≥4, <8 drinks: adjusted odds ratio [aOR], 37.568; 95% confidence interval [CI], 9.793–144.116; ≥8 drinks: aOR, 20.350; 95% CI, 20.350–305.138). On the other hand, the abnormal GGT expression in the flushing group was significantly increased in every weekly drinking amount range (<4 drinks: aOR, 4.120; 95% CI, 1.603–10.585; ≥4, <8 drinks: aOR, 79.206; 95% CI, 24.034–261.031; ≥8 drinks: aOR, 111.342; 95% CI, 30.987–400.079). For each weekly drinking amount range, the flushing group showed significantly higher abnormal GGT expression than the non-flushing group (<4 drinks: aOR, 3.867; 95% CI, 1.786–8.374; ≥4, <8 drinks: aOR, 57.277; 95% CI, 24.430–134.285; ≥8 drinks: aOR, 104.871; 95% CI, 42.945–256.091). Conclusion: This study showed that abnormal GGT expression in the flushing female drinkers was induced by smaller amounts of alcohol than in the non-flushing female drinkers.
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Yu Ri Seo,김종성,Sung Soo Kim,Seok-Joon Yoon,서원윤,Kwangmi Youn 대한가정의학회 2016 Korean Journal of Family Medicine Vol.37 No.1
Background: This study aimed to develop a simple tool for identifying alcohol use disorders in female Korean drinkers from previous questionnaires. Methods: This research was conducted on 400 women who consumed at least one alcoholic drink during the past month and visited the health promotion center at Chungnam National University Hospital between June 2013 to May 2014. Drinking habits and alcohol use disorders were assessed by structured interviews using the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition diagnostic criteria. The subjects were also asked to answer the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-Consumption, CAGE (Cut down, Annoyed, Guilty, Eye-opener), TWEAK (Tolerance, Worried, Eye-opener, Amnesia, Kut down), TACE (Tolerance, Annoyed, Cut down, Eye-opener), and NET (Normal drinker, Eye-opener, Tolerance) questionnaires. The area under receiver operating characteristic (AUROC) of each question of the questionnaires on alcohol use disorders was assessed. After combining two questions with the largest AUROC, it was compared to other previous questionnaires. Results: Among the 400 subjects, 58 (14.5%) were identified as having an alcohol use disorder. Two questions with the largest AUROC were question no. 7 in AUDIT, “How often during the last year have you had a feeling of guilt or remorse after drinking?” and question no. 5 in AUDIT, “How often during the past year have you failed to do what was normally expected from you because of drinking?” with an AUROC (95% confidence interval [CI]) of 0.886 (0.850–0.915) and 0.862 (0.824–0.894), respectively. The AUROC (95% CI) of the combination of the two questions was 0.958 (0.934–0.976) with no significant difference as compared to the existing AUDIT with the largest AUROC. Conclusion: The above results suggest that the simple tool consisting of questions no. 5 and no. 7 in AUDIT is useful in identifying alcohol use disorders in Korean female drinkers.
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