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      • SCOPUSKCI등재

        간장 및 담도 : HBsAg 양성 공혈자의 임상적 경과 및 조직학적 관찰

        문한규(Han Kyu Moon),이승모(Seung Mo Lee),윤명순(Myeong Soon Yoon),김영훈(Yeung Hoon Kim) 대한소화기학회 1986 대한소화기학회지 Vol.18 No.1

        N/A Of 869 patients, who had HBsAg positive donors reported by Kim et al., 21 patients were followed up from Oct. 1982 to May 1983 with 2 to 4 weeks interval via the department of internal medicine of BNUH. They vere studied careful history, biochemical liver function test and liver biopsy. And the following results were obtained; 1) Of 21 patients, 18 patients who had complained with clinical symptoms or abnormal biochemical liver function test(86%) had the evidence of chronic liver disease and all 9 biopsied patients of 18 patients had the evidence of the chronic liver disease. 2) Of 3 HBsAg persistent patients without clinical symptom or biochemical liver function test, one biopsied patient had the evidence of nonspecific reactive hepatitis. 3) As the above results, in the case of persistently HBsAg patient without clinica1 symptom or abnormal liver functon test, the many patients do not need the liver biopsy in spite of infrequently chronic liver disease. But in case with abnormal clinical or biochemical finding, the most patients need the actual examination including liver biopsy and management because of possibly involving by chronic liver disease.

      • SCOPUSKCI등재

        만성 활동성 간염에 있어 생화학적 , 혈청학적 및 조직학적 소견의 비교 관찰

        문한규(Han Kyu Moon),심원보(Won Bo Shim),서영도(Yeong Do Suh),윤명순(Myeong Soon Yoon),김영훈(Ywong Hoon Kim),박형구(Hyung Koo Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1

        N/A The authors have evaluated thirty-two patients of chronic active hepatitis ccnfirmed by needle biopsy of liver to compare the biochemical values in the group of HBeAg with those in the group of HBeAg(-), and to compare the biochemical values according to histologic severity. The patients were composed of male 26, female 6, and the mean age was 35. 5 years. There was not any significant difference of age between male and female. The incidences of HBV markers were 75% in HBsAg, 19% in Anti-HBs, 97% in Anti-HBc, 47% in HBeAg, and 16% in Anti-Hbe by radioimmunoassay, but there was not any significant difference of the incidences of HBV markers according to histologic severity. The activity of aminotransferase was elevated more in the group of HBeAg(+) compared to the group of HBeAg(-), but there was not any significant difference between the two groups. The activity of aminotransferase and the value of globulin were elevated more in the group having bridging necrosis compared to the group having piecemeal necrosis only or with focal necrosis without bridging necrosis, but there was not any significant difference between the two groups. The authors conclude that it is absurd to predict the histologic severity of chronic active hepatitis with the persistence of HBsAg or HBeAg, or with the values of biochemical test.

      • KCI등재후보

        약물에 의한 무과립구중에 동반된 급성 맹장염(Acute Typhlitis) 1 예

        윤명순,정유성,이시래,배현호,장인득,이종명,허동,홍윤범,허길,이종명 대한내과학회 1997 대한내과학회지 Vol.52 No.5

        Increasingly aggressive chemotherapy regimens, advances in transplantation technology, and the acquired immunodeficiency syndrome have resulted in a growing number of immunocompromised patients. Infections are a major cause of morbidity and mortality in this population. One of the most ominous complications is the development of typhlitis in this immunocompromised patients. Treatment of this process is controversial, and no consensus has emerged. We report a case of typhlitis who complicated agranulocytosis after exposure to drugs to treat $quot;flu$quot; like illness and recovered completely after two operations of appendectomy and ileocolectomy. Reviewing articles and this case, the favorable outcome seemed to be related to following three factors recognition of the acute surgical abdomen by abdominal CT scan, a prompt return of normal circulating white cells by the use of Granulocyte Colony Stimulating Factor and discontinuation of causative drugs, and an appropriately timed surgical intervention.

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