임신성 급성지방간 보고

서민아 ( Min A Seo ),김창운 ( Chang Woon Kim ),권민정 ( Min Jung Kwon ),지병주 ( Byung Ju Ji ),박경도 ( Kyung Do Park ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.5

Acute fatty liver of pregnancy are relatively rare but extremely dangerous, because they may quickly develop into a fulminant disease and become a serious life-threatening disorder for mother and fetus in the third trimester. Therefore, early diagnosis, prompt delivery and intensive supportive care the cornerstones in the management of acute fatty liver of pregnancy. Clinical findings in acute fatty liver of pregnancy vary because it may occur with varying degrees of clinical severity and in conjunction with other third trimester symptoms, making early diagnosis difficult. However, careful history and physical examination, in conjunction with compatible laboratory and imaging results, are often sufficient to make the diagnosis, and liver biopsy is rarely indicated. We have experienced a case of acute fatty liver of pregnancy presenting as early hepatic encephalopathy, renal failure which developed during the third trimester. We diagnosed acute fatty liver of pregnancy based on clinical presentation and laboratory abnormalities. Despite of prompt delivery and adequate supportive care management, this severe complication of pregnancy has had an adverse outcome for mother.

용도지역의 공간적 특성과 범죄발생 특성 분석 연구

서민진(Min-jin Seo),서연아(Yeon-a Seo),강석진(Seok-jin Kang) 한국셉테드학회 2019 한국셉테드학회지 Vol.10 No.3

Developed at the center of the Old Downtown, J-City became a multi-centralization structure as the functions of the city center were dispersed after the creation of the innovative city, and the Old Downtown is declining due to the reduction of the floating population and the differentiation of functions. Crime data analysis shows that theft-crime hot spot are forming in the newly formed urban areas, but hot spots in the Old Downtown are also steadily maintained. In this study, the relationship between crime and spatial characteristics and physical factors was analyzed among residential Areas and commercial Areas located in the Old Downtown of J-City, based on the most frequent cases of theft in the A-Dong (Residential Areas) and B-Dong (Commercial Areas). The targeted crime was set at the center of theft (street, invasion) considered controllable by the CPTED(Crime Prevention Through Environmental Design). Physical factors to be used for analysis through prior research were classified as street characteristics, building characteristics, facilities and space characteristics, crime safety characteristics, and space characteristics. The study found that first, in the residential Areas of A-dong theft is related to emergency bell Presence or Absence and fifth major crimes are related to street-wide appropriateness, emergency bell Presence or Absence and integration, and violent crime is related to entertainment place. In particular, crime tended to increase as the degree of integration by segmented axial angle analysis was reduced. This is consistent with existing studies, which show that the centrality of space and the amount of walking (or floating population) are closely related to crime. Second, in the commercial Areas of B-dong, there was no significant relationship between theft and five major crimes with physical factors. But Violent crimes were found to be related to the state of management of the street environment, whether or not to enter a separate space, whether empty houses or public notices are available, and Presence or Absence there is a safe place (convenience store). Third, the analysis of the relationship between spatial characteristics and theft without distinction of use area showed that appropriateness of street width, cleaning and management of street, hideable obstacle, management of entrance door on the first floor, installation of barrier windows, CCTV monitoring range, lighting facility, visibility of crime facilities, entertainment center, and safe space are related to crime. The area under study is narrow and the crime sample is small, so the generalization of the results is limited. But, The significance of the research is that the differences in the physical environment of each Land Use Areas were identified and the occurrence of theft changed depending on the spatial characteristics and physical factors. In subsequent studies, it is necessary to consider the relationship of criminal occurrence by combining the characteristics of the social population along with the spatial characteristics for a wider range of use areas. 원도심을 중심으로 발달한 J시는 혁신도시조성 후 도심 기능이 분산되면서 다핵화 구조가 되었고, 유동인구 감소 및 기능의 분화로 원도심은 쇠퇴하고 있다. 범죄자료 분석결과 새로 형성된 도심지역으로 절도범죄 핫스팟이 형성되고 있지만 원도심에서의 핫스팟도 꾸준히 유지되는 것으로 나타났다. 이에 본 연구에서는 J시 원도심에 위치한 주거밀집지역과 상가밀집지역 중 절도범죄가 가장 많이 일어난 A동(주거밀집지역)과 B동(상업밀집지역)을 대상으로 범죄와 공간특성 및 물리적 요인의 관계를 분석하였다. 대상 범죄는 범죄예방디자인(Crime Prevention Through Environmental Design, CPTED)으로 통제 가능하다고 여겨지는 절도범죄(노상, 침입) 중심으로 설정하고, 선행연구고찰을 통해 분석에 사용할 물리적 요인은 가로특성, 건물특성, 시설특성, 범죄안전 특성, 공간구조 특성으로 분류하였다. 연구결과 첫째, 주거밀집지역인 A동에서 절도범죄는 비상벨 유무, 5대 범죄는 가로 폭의 적절성, 비상벨 유무, 통합도와 관계가 있으며, 폭력범죄는 유흥업소와 관계가 있는 것으로 나타났다. 특히 분절축선 각도분석에 의한 통합도가 낮아질수록 범죄가 증가하는 경향이 있었는데, 이는 기존 연구와 일치하는 것으로 공간의 중심성과 보행량(또는 유동인구)이 범죄와 밀접한 관련이 있음을 알 수 있다. 둘째, 상업밀집지역인 B동에서는 절도범죄와 5대 범죄는 물리적 요인과 유의미한 관계는 확인되지 않았지만, 폭력범죄는 가로환경 관리상태, 이격공간 출입통제 여부, 빈집 또는 공지여부, 안심공간(편의점) 유무가 관계가 있는 것으로 나타났다. 셋째, 용도지역을 구분하지 않고 공간적 특성과 절도범죄의 관계를 분석한 결과 가로 폭의 적절성, 가로의 청소 및 관리상태, 은신가능 장애물, 1층 출입문 관리상태, 방범창 설치여부, CCTV 감시범위, 조명시설, 방범시설 시인성, 유흥업소, 안심공간 유무 등이 범죄와 유의미한 관계가 있는 것으로 나타났다. 연구대상 지역의 범위가 협소하고 범죄표본이 적어 결과의 일반화에 한계가 있지만 용도지역별 물리적 환경의 차이를 규명하였고, 공간적 특성 및 물리적 요인에 따라서 절도범죄 발생이 변함을 확인했다는 측면에서의 연구의 의의를 가진다. 후속 연구에서는 보다 다양한 용도지역을 대상으로 공간적 특성과 함께 사회인구적 특성을 종합하여 범죄발생의 관계를 고찰할 필요가 있다.

자궁경부 편평상피암에서 DDRT-PCR 기법을 이용한 유전자 발현 및 Gene Ontology 분석

서민제 ( Seo Min Je ),배수미 ( Bae Su Mi ),박경미 ( Park Gyeong Mi ),김병훈 ( Kim Byeong Hun ),김용완 ( Kim Yong Wan ),서경윤 ( Seo Gyeong Yun ),서경아 ( Seo Gyeong A ),김용욱 ( Kim Yong Ug ),허수영 ( Heo Su Yeong ),노덕영 ( No De 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4

목적: 인유두종 바이러스 감염에 의한 자궁경부암 발생에 대한 자연사 (natural history)는 비교적 잘 알려져 있으나 분자생물학적인 면에서의 병태생리는 아직 명확하게 규명되어 있지 않다. 자궁경부 편평상피암 조직에서 유전자 발현 양상을 조사하여 암화과정에 관여하는 유전자들의 다양한 기능과 상호작용에 대해서 알아보고자 하였다. 연구 방법: 양성질환으로 자궁 적출술을 시행한 17명의 자궁경부에서 추출한 RNA를 동일한 농도로 섞어 대조군으로 이용하 Objective: The molecular pathology of cervical cancer associated with human papillomavirus infection is presently unclear. In an effort to clarify the multiple interactions of a number of genes involved in cervical carcinogenesis, the gene expression prof

수평형 태양전지 일체형 창호를 적용한 사무소 건물의 에너지 성능 분석

서민채(Seo, Min-Chae),박보랑(Park, Bo-Rang),김아영(Kim, A-Young),윤지영(Yun, Ji-Young),문진우(Moon, Jin-Woo) 한국생태환경건축학회 2023 한국생태환경건축학회 학술발표대회 논문집 Vol.23 No.2

욕창치료진단기기의 생체 적합성 향상을 위한 사용성평가

서민아(Min-A Seo),조상우(Sangwoo Cho),윤범석(Beom Seok Yun),이종하(Jong-Ha Lee) 대한인간공학회 2022 대한인간공학회 학술대회논문집 Vol.2022 No.10

종아리근 단축 대상자에게 목말뼈 후방활주 테이핑을 이용한 관절가동술 적용과 근막이완기법의 적용이 동적 균형의 운동학적 변화에 미치는 영향

서민아(Min-A Seo),정규나(Kyu-Na Jeong),김유진(Yu-Jin Kim),이유진(Yu-Jin Lee),황영인(Young-In Hwang) 한국전문물리치료학회 2022 한국전문물리치료학회지 Vol.29 No.1

Background: Individuals with calf muscle shortening may have decreased dynamic balance. Objects: This study aimed to investigate the effect of mobilization with movement (MWM) and myofascial release (MFR) on kinematic changes in dynamic balance in individuals with calf muscle shortening. Methods: Thirteen participants were randomly assigned to the MWM or the mobilization with movement added myofascial release (MWM-MFR) group. The MWM group received treatment with only MWM, whereas the MWM-MFR group was treated with MWM and MFR. Pre- and post-intervention passive range of motion (PROM), maximum reaching lengths, and modified star excursion balance test (MSEBT) results were compared for all participants. Wil-coxon signed-rank test and Mann-Whitney U test were used for statistical analysis. Results: The results showed significant within-group differences in ankle PROM, but no sig-nificant between-group differences. The maximum reaching length in the MWM-MFR group in the posterolateral direction was significantly different before and after the intervention (p = 0.005). This group also showed significantly reduced ankle abduction in MSEBT during the posteromedial direction section 3 (p = 0.007) and posterolateral direction section 5 (p = 0.049) compared with the MWM group. Conclusion: Combined MWM and MFR intervention improves ankle stability in the coronal plane during the posteromedial and posterolateral forward movement in dynamic balance compared with only MWM in individuals with calf shortening.

수막재배시설 실내공기 중 라돈 농도 특성에 관한 연구

김상철 ( Sang-cheol Kim ),박찬주 ( Chan-ju Park ),최재혁 ( Jae-hyuk Choi ),서민아 ( Min-a Seo ),엄진균 ( Jin-gyun Eom ),박미선 ( Mi-sun Park ) 한국환경분석학회 2021 환경분석과 독성보건 Vol.24 No.2

TheaimofthisstudywastoinvestigateindoorradonconcentrationinthewatercurtaincultivationfacilitieslocatedintheruralareaofSejongcityduringthewinterseason.Thebedrockofthesouthernpartofthecityismainlycomposedofgraniterocks,whichhavebeenreportedtoretainhigherradoncontentthansedimentaryandmetamorphicrocks.Themeasuredindoorradonconcentrationswereveryhighinallthefacilitiespartiallyexceedingtherecommendedvaluesprovidedinthe「IndoorAirQualityControlAct」guidelines.Furthermore,weobservedthatoperationofequipmenttomaintainstableindoortemperaturesresultedindiurnalvariationsinradonconcentration.Basedontheresults,weconcludedthatsuitablemeasuressuchaschangingthetimeatwhichworkstartsorventilatinginadvancecouldhelpreducethedurationofexposuretoradon.

TGF-β1 Expression by Proliferated Keratinocytes in the Skin of E-Irradiated Mice

A-Ran Yoon(윤아란),Do Nyun Kim(김도년),Min Koo Seo(서민구),Sang Taek Oh(오상택),Jung Seon Seo(서정선),Se Mo Jun(전세모),Jung-Ho Cha(차정호),Seungdeok Lee(이승덕),Suk Kyeong Lee(이숙경) 한국생명과학회 2012 생명과학회지 Vol.22 No.2

우리는 방사선피부염 동물 모델을 확립하여, 이차 면역 기관에서의 면역 세포 비율 변화를 관찰하였다. 또한, 방사선 조사에 의한 병소에서 transforming growth factor-β1 (TGF-β1)과 interlukin-10 (IL-10)의 발현을 증가시킨 세포를 분석하였다. Hairless-1 (HR-1) 쥐의 posterior dorsal 부위에 6 일간 매일 10 Gy 씩 electron (E)-ray를 국부 조사하여 방사선피부염 모델을 만들었다. FACS를 이용하여 면역 세포 비율의 변화를 분석한 결과 비장과 림프절에 존재하는 항원제시세포와 T 세포 및 B 세포들의 비율이 E-irradiation에 의해 영향을 받았다. 피부에서 세포 특이적인 마커와 사이토카인들의 발현 양상은 면역형광염색법으로 확인하였다. 방사선 조사 후, TGF-β1과 interlukin-17 (IL-17)은 regulatory T 세포(Treg)보다 keratin-14 (K-14)를 발현하는 진피의 끝부분에서 높게 발현되었다. Interlukin-10 (IL-10)는 Treg 뿐만 아니라 T helper 17 (Th17) 세포, dendritic 세포, macrophage 중 어느것과도 같은 위치에서 검출되지 않았다. 우리의 데이터는 방사선피부염 동물 모델의 병소 안에서, TGF-β1이 증식된 keratinocyte에 과발현된다는 것을 나타낸다. In this study, we established a radiodermatitis animal model and investigated the change in immune cell proportions in the secondary lymphoid organs. The cells responsible for the increased transforming growth factor-β1 (TGF-β1) and interleukin-10 (IL-10) production in the lesions following irradiation were also investigated. The radiodermatitis model was constructed by locally exposing the posterior dorsal region of hairless-1 (HR-1) mice to 10 Gy electron (E)-ray/day for six consecutive days. The change in immune cell proportions was analyzed by FACS. Immunohistochemistry was carried out to detect the expression of cytokines and cell-specific markers in the skin. The proportions of antigen-presenting cells, T cells, and B cells in the lymph nodes and spleen were affected by E-irradiation. After irradiation, TGF-β1 and IL-17 were co-localized in the papillary region of the dermis with keratin-14 (K-14)-positive cells rather than with regulatory T cells (Treg). IL-10 was not co-stained with Treg, T helper 17 (Th17) cells, dendritic cells, or macrophages. Our data indicate that TGF-β1 is over-expressed mainly by proliferated keratinocytes in the lesions of a radiodermatitis animal model.

3D 카메라 스캐너를 통한 최적의 LED 마스크 가드 사이즈 도출 연구

서민아(Min A Seo),조상우(Sangwoo Cho),윤범석(Beom Seok Yun),이종하(Jong-Ha Lee) 대한인간공학회 2022 대한인간공학회 학술대회논문집 Vol.2022 No.4

5G기반 자율주행차 주요 기술 동향 및 교육지원 하이라이트

서민아(Min A Seo),전예랑(Ye Rang Jeon),최해운(Hae Woon Choi) 한국자동차공학회 2022 한국자동차공학회 부문종합 학술대회 Vol.2022 No.6