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지속성 외래 복막투석중인 당뇨성 신부전에서 Verapamil 의 복강내 투여가 β2 - Microglobulin 에 미치는 영향
변현주(Hyun Ju Byun),차대룡(Dae Ryong Cha),권현민(Hyun Min Kwon),권영주(Young Ju Kwon),조원용(Won Yong Cho),김형규(Hyoung Kyu Kim) 대한내과학회 1991 대한내과학회지 Vol.41 No.5
N/A In diabetic renal failure, generalized vasculopathy including capillaries is presented, and so there may be some difference in ultrafiltration and mass transport from that of non-diabetic renal failure. Recently, several studies show that intraperitoneal administration of Ca++ antagonist may increase ultrafiltration and mass transport of small molecular weight substance in CAPD. It suspected that the effect of intraperitoneal administration of verapamil on CAPD, may have different response in diabetic and non-diabetic renal failure. In order to evaluate the effects of calcium antagonist (verapamil) on the permeability of the peritoneal membrane in patients on CAPD, serum levels and clearances of creatinine, urea, and β2-Microglobulin, mass transferarea coefficient, ultrafiltration rate and glucose absorption were measured. The study group was devided by 5 non-diabetic (age 33.4+12.4 years, treated for 10.1+8.4 months, Group I) and 5 diabetic (age 53.2+13.7 years, treated for 16.6+15.2 months, Group II) renal failure patients and the study was carried out using 1.65% dextrose dialysate solution for 240 minutes dwell time (phase I), and after the intraperitoneal administration of 10 mg of verapamil the peritoneal dialysis was done by same method as phase I (1phase II). To evaluate the effects of verapamil, percent difference of change between phase I and phase II was calculated. All the values here are mean. The results are: 1) Serum levels of creatinine and β2-Microglobulin were lower in Group II (11.4 vs 6.8 mg/dl, 39.4 vs 18.2 mg/dl) (p<0,01). 2) Peritoneal clearance of creatinine was higher in Group II (6.322 vs 7.072 ml/min), but the increasing rate after instillation of verapamil was slightly lesser than Group I (6.5 vs 4.0%) (not significant). 3) Peritoneal clearance of β2-Microglobulin was higher in Group II (0.626 vs 0.88 ml/min), and the increasing rate after instillation of verapamil was marked in both group, especially in Group I (83.5 vs 36.1%) (not significant). 4) MTAC was higher in Group II (9.7 vs 12.78 ml/min), but the increasing rate of it was greater in Group I (15.4 vs 3.58%) (not significant). The peritoneal permeability was greater in Group 1I probably due to increased permeability and changed structures of peritoneal capillaries in diabetic disease, and the effects of calcium antagonist (verapamil) on peritoneal permeability was lesser in Group II. It suggests that the intraperitoneal administration of verapamil increase the efficiency of CAPD in general, but the benefit may be lesser in diabetic patients.
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어병세균 Edwardsiella tarda에 대한 한약재 추출물의 항균활성
김아라 ( Ah Ra Kim ),김도균 ( Do Kyun Kim ),변태환 ( Tea Hwan Byun ),조은지 ( Eun Jee Jo ),이은우 ( Eun Woo Lee ),권현주 ( Hyun Ju Kwon ),김병우 ( Byung Woo Kim ),김태훈 ( Tae Hoon Kim ),이경본 ( Kyung Bon Lee ),김영만 ( Young Man 한국식품저장유통학회(구 한국농산물저장유통학회) 2011 한국식품저장유통학회지 Vol.18 No.1
The methanol extracts of 19 commercial herb medicines was analyzed to antibacterial activities against Edwardsiella tarda, causing several fish diseases. Rhus javanica showed most strong antibacterial activity against E. tarda and Escherichia coli. Methanol extract of R. javanica was further extracted using several organic solvents having different polarity. Extract from ethyl acetate fraction showed strong activity against E. tarda as well as E. coli. Minimal inhibitory concentration, MIC of R. javanica extract was measured and resulted showing 64 ㎍/㎖ for E. tarda and 256 ㎍/㎖ for E. coli. It is needed that, from these results, further purification and isolation of reposible compound of these activities and further study on the synergy effect using combination with antibiotics against pathogenic bacteria.
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김용섭,차대룡,변현주,권현민,권영주,조원용,김형규,원동준 대한내과학회 1992 대한내과학회지 Vol.42 No.2
신증후 출혈열(HFRS)은 바이러스에 의해 발생되는 출혈열의 일종으로 임상경과중 급성 신부전과 다량의 단백뇨를 발생하는 질환으로 단백뇨의 발생기전에 대해서는 이론이 많다. 최근 HFRS환자의 신조직검사상 신간질에 침윤된 T 임파구가 신기능 이상 및 단백뇨 발생과 어떠한 연관이 있을 것이란 연구결과가 있어 이에 저자들은 전형적인 HFRS의 임상소견을 보이고 급성 신부전의 임상경과를 보인 14예에서 핍뇨기와 이뇨기의 혈장과 소변에서 여러 가지 생화학적 지표와 RIA방법을 이용한 Interleukin 2(IL-2)를 측정하고 대조군의 IL-2와 비교하여 다음과 같은 결과를 얻었다. 1) HFRS 환자에서 24시간 단백뇨는 핍뇨기에서 731.6±106.9㎎/㎗보다 유의성이 있었으며(p=0.0009), 대조군의 36.5±8.6㎎/㎗ 보다도 유의성이 있었다(p<0.0000). 2) HFRS 환자의 혈장 IL-2는 핍뇨기와 이뇨기에서 각각 7.85±0.37f㏖/㎖, 7.19±0.29f㏖/㎖으로 유의성이 없었으나(p=0.13), 대조군의 5.89±0.14f㏖/㎖와는 각가 유의성이 있었다(p=0.005). 3) HFRS 환자의 핍뇨기에서 소변 IL-2는 5.07±1.06f㏖/㎎Cr으로 이뇨기의 0.35±0.05f㏖/㎎Cr (p=0.009)에 비해 유의성이 있었다. 4) HFRS 환자의 핍뇨기에서 혈장 IL-2와 24시간 단백뇨와는 정비례 관계를 보였으며(r=0.64, p<0.09), 크레아티닌 제거율과 소변 IL-2는 역비례 관계를 보였다. (r=-0.73, p<0.04) 이상의 결과로 볼 때 HFRS에서 신기능 이상의 병태생리와 신간질에 침윤된 T임파구에서 분비되는 IL-2와 유관할 것으로 생각되며, 또한 IL-2가 단백뇨에도 영향을 미칠것이라고 추측된다. Background. Recently renal biopsy findings in Hemorrhagic Fever with Renal Syndrome (HFRS) shows that T lymphocytes infiltrated in renal interstitium may associate with abnormal renal function and proteinuria. Therefore. to speculate the role of Interleukin 2 (IL-2) for proteinuria and renal function, author estimated IL-s in serum and urine in oliguric and diuretic phase of patients who were proved serologically and showed typically clinical manifestations of HFRS. Methods. Authors selected 14 patients who have classic manifestations of HFRS with acute renal failure during clinical course. The conventional studies were performed and serum and urine IL-2 were measured in oliguric and diuretic phase of HFRS with RIA. Also, above measurements wer performed in control group Results. 24 hours proteinuria in oliguric phase (731.6±106.9㎎/day) was significantly higher than in diuretic phase (499.9±275.2㎎/day) (p=0.0009) and also significantly higher than normal control group (36.5±8.6㎎/㎗) (p=0.0000). There was no significant difference in serum concentration of IL-2 between oliguric and diuretic phase (p=0.12), but there was significant difference compared with that of control group, respectively (p<0.01). The excretion of urine IL-2 of HFRS patients in oliguric phase (5.07±1.06f㏖/㎎Cr) were significantly higher than patients in diruretic phase (0.35±0.05f㏖/㎎Cr) an control group (0.78±0.27f㏖/㎎Cr) and control group (0.78±0.27f㏖/㎎Cr) (p<0.05). In oliguric phase of HFRS patients, serum IL-2 and 24 hours proteinuria showed positive correlation (r=0.64, P=0.09) and creatinine and urine IL-2 showed reverse correlation (r=-0.73, p=0.04). Conclusion. Authors consider that IL-2 have a significant role for proteinuria and renal function in the patient with HFRS.
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