http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박정서,김신종,백운필,이현주,송윤석,장정민 明知大學校 自然科學硏究所 1997 자연과학논문집 Vol.15 No.-
Biphenyl의 para position에 methylene group을 도입 시키는 방법으로 paraformaldehyde와 dimethylamine을 반응시켜 Mannich Base인 (1,1'-biphenyl-4,4'-dimethyl)-dimethli amine을 합성해 보았으나, 전혀 반응이 진행되지 않았다. 즉 , Biphenyl에 강한 activating group이 없으므로 Mannich Base을 사용한 방법은 효과적이 못된다. 따라서, 다른 방법으로 biphenyl에 bromomethylation을 진행 시켜서, 두 개의 methylene group을 도입시켰다. Bromomethylation은 다음과 같이 사용하는 시약 및 실험 방법 등을 고려하여 3가지 방법으로 시도 하였다. 1)1,3,5-trioxane + HBr in AcOH + paraformaldehyde 사용법, 2)Hbr in AcOH + paraformaldehyde 사용법, 3) NaBr + H₂SO₄+paraformaldehyde 사용법, 이상의 3가지 방법 중에서 NaBr+ H₂SO₄+ paraformaldehyde 사용법이 가장 좋은 결과를 얻었다. 이러한 system에서 반응을 진행시킨 결과 69% 의 높은 수율 (87%의 purity)로 4,4'-dibromomethylbiphenyl 합성에 성공할 수 있었다. The synthetic method for the induction of methylene group on the para position of arenes is of importance. Since the weak activation effect of phenyl group on the electrophilic substitution reaction, the induction of methylene group by way of Mannich base using paraformaldehyde and dimethylamine was unsuccessful. It was found that halomethylation of byphenyl is only the way for the preparation of di-p-methylenebiphenyl. Especially, bromomethylation was turn out to be more reliable synthetic method than chloromethylation. Herein, we developed 3 protocols for the synthesis of 4,4'-dibromomethylbiphenyl. In addition, the best result was obtained using NaBr + H₂SO₄paraformaldehyde protocol in 69% yield.
간경변증을 동반한 당뇨병 환자에 있어서 2 차적으로 발생한 피부괴사 1 예
남은숙,김응진,강신재,김희연,홍한기,백정민,오영배,이찬주,김혜랑,곽호근,유정하 대한내과학회 1995 대한내과학회지 Vol.49 No.6
It has long been recognized that the liver plays an important role in carbohydrate homeostasis. Petrides reported that Diabetes mellitus in insulin resistant cirrhotic patients developed as the result of progressive impairment in insulin secretion with the development of hepatic insulin resistance leading to fasting hyperglycemia and a diabetic glucose tolerance profile. Diabetic patients with debilitating illness, including hepatic cirrhosis and acute alcoholic heptitis, appear to be more prone to infections, and the accumulating evidence for an immunological defect superimposed upon the metabolic abnormalities of diabetes is becoming increasingly convincing. We described a patient with diabetes mellitus and liver cirrhosis who has purpura on body due to falling down, resulting in perineal and scrotal necrosis (Fournier`s gangrene) as well as foot gangrene. Despite aggressive antibiotic therpy and debridement, Foumier`s gangrens is associated with a high motality. We performed necrotic skin resection and reconstrucitve procedure with massive antibiotics therapy