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한국인 위암 발생의 원인 인자로서 Helicobacter pylori CagA 의 역할에 관한 연구
남은숙,김우중,김학양,유재영,박충기,김종혁,김용범,주상언 대한소화기학회 1998 대한소화기학회지 Vol.31 No.2
Background/Airns: Gastric cancer is one of the most prevalent malignant tumors and is a leading cause of cancer death in the world. Recent studies have been shown that Helicobacter pylori (H. pylori) can colonize the gastric mucosa for decades and are strongly associated with chronic atrophic gastritis, a lesion that is a precursor of gastric cancer. Although H. pylori infection is frequently observed in patients with gastric cancer, most H. pylori infected persons never develop gastric cancer. Some other factors may be related to differences between the infecting bacterial strains of H. pylori. We investigated the relationship between CagA status and the development of gastric cancer in Korea. Methods: Gastroduodenoscopy was done in patients with upper gastrointestinal complaints. During the examination, rapid urease test for the presence of H. pylori infection was done using gastric biopsy specimens taken from normal gastric antrum. Sera were collected from 20 chronic gastritis patients and 25 gastric cancer patients with H. pylori infection. Western blotting was carried out using a comrnercially prepared kit-Helicoblot 2.0. Results: Antibodies to CagA were significantly more prevalent in the group with chronic gastritis (14/20, 70%) than in those with gastric cancers (14/25, 56%)(p$lt;0.01). According to Lauren classification of gastric cancer, the number of patients with intestinal type was 13 and diffuse type was 12. Antibodies to CagA were more prevalent in the diffuse type than in the intestinal type (8/12, 67% and 6/13, 46% respectively, p$lt;0.01). Conclusions: Infection with CagA positive H. pylori strain is not associatecl with an increased risk for the development of gastric cancer in Korea.
남은숙 여성건강간호학회 1997 여성건강간호학회지 Vol.3 No.2
The purpose of this study is to investigate the effect of an educational program on parturient women's feeding behavior. One hundred and twenty seven mothers who delivered in one general hospital in Seoul participated in the study, 66 mothers of whom were assigned to experimental group and 61, to control group. The data collection was done from April 20 to June 30 in 1997 and the educational program was applied to the experimental group on the third postpartum day and telephone calls were made on the fourth and the twelfth postpartum week to investigate feeding behavior after discharge. The collected data were analyzed by means of Chi-square test and descriptive statistics. The results are as follows : 1. Breastfeeding rate of the experimental group was higher than that of the control group(x²=6.578 , p=.043). 2. Background variables affecting feeding behavior were age and feeding plan(age: x²=8.660, p=.070, feeding plan: x²=25.762, p=.000). 3. The insufficient milk supply was the main cause of discontinuing breastfeeding and others were mother's job, baby's jaundice and diarrhea, baby's refusal to suck breast-milk. In conclusion, the breastfeeding educational program which was applied in this study is effective in the promotion of breastfeeding.
Maspin Suppresses Survival of Lung Cancer Cells through Modulation of Akt Pathway
남은숙,박채화 대한암학회 2010 Cancer Research and Treatment Vol.42 No.1
Purpose :Maspin is a tumor suppressor protein that has been reported to stimulate the cell death of cancer and inhibit the metastasis of cancer. The present study aimed to explore the survival pathway by which maspin modulates the resistance of human lung cancer cells to chemotherapeutic drugs, and the consequences of maspin gene therapy in an animal model. Materials and Methods :NCI-H157 and A549 cells were transfected with either a mock vector (pCMVTaq4C), maspin (pCMV-maspin), siControl or siMaspin. RT-PCR and Western blot analysis were performed to study the expressions of survival proteins in lung cancer. cDNA microarray analysis was carried out to compare the maspin-modulated gene expression between the xenograft tumors derived from the lung cancer cells that were stably transfected with pCMVTaq4C or pCMV-maspin. Maspin gene therapy was performed by intra-tumoral injections of pCMVTaq4C or pCMV-maspin into the pre-established subcutaneous tumors in nude mice. Results :Maspin significantly decreased the survival to doxorubicin and etoposide, whereas did not affect the survival to cisplatin in the NCI-H157 cells. Interestingly, transfection with a maspin plasmid resulted in a significant reduction of the phosphorylation of Akt in the NCI-H157 cells, whereas knockdown of maspin increased the phosphorylation of Akt in the A549 cells. Microarray analysis of the xenograft tumors revealed a specific gene expression profile, demonstrating that maspin is associated with the differential expressions of PTEN and IGF2R. Direct transfer of pCMV-maspin into the tumor significantly retarded the tumor growth in the animal experiments (p=0.0048). Conclusion :Lung cancer cells lacking maspin could be resistant to chemotherapeutic drugs such as doxorubicin or etoposide, at least in part by maintaining Akt phosphorylation.
사회적 지지가 스트레스 및 적응에 미치는 효과에 관한 고찰
남은숙 中央醫學社 1991 中央醫學 Vol.56 No.3
Social support serves as a moderator of life stress by assisting coping, adaptation during life transition and crisis. It has a positive influence on health and well being generally. Social support encompasses three components of affect, affirmation, and aid conceptually. Recent research indicates that the direct and buffering effects of social support on health and well being are not necessarily mutually exclusive but may function simultaneously. Lack of social support increases mortality risks, and stress and social support influences physical and emotional symptomatology. Social support can protect people in crisis from a wide variety of pathological states: from low birth weight to death, from arthritis through tuberculosis to depression, alcoholism, and the social breakdown syndrome. Social support may reduce the amount of medication required, accelerate recovery, and facilitate compliance with prescribed medical regimens. The relations of social support and morbidity, recovery from illness, health practice are ,not consistently established and further research. is needed.