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- 저자 : 배종화(Jong Hwa Bae) (검색결과 18 건)
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새 방법에 의한 승모판협착중에서의 승모판구 면적측정에 관한 연구
배종화(Jong Hoa Bae),최철준(Chul Joon Choi),조정휘(Chung Whee Choue),김권삼(Kwon Sam Kim),김명식(Myung Shick Kim),송정상(Jung Sang Song),정충화(Chong Hwa Jung) 대한내과학회 1990 대한내과학회지 Vol.39 No.1
N/A A new formula (ED-MVA) was derived from the study of fluid dynamics, that the flow volume is proportional to orifice area, velocity of flow, and which shows period required by the flow. The mitral inflow volume can be obtained by estimating the stroke volume (SV) by Teichholz's method from M-mode echocardiogram of the left ventricle, and the mean diastolic velocity (MDV) and diastolic filling period (DFP) by mitral inflow continuous-wave Doppler echocardiogram, respectively. Therefore, the new Echo/Doppler method is MVA= SV/MDV×DFP. We compared this new method to other methods in 28 patients with severe mitral stenosis. The following results were obtained: 1) MVAs of 28 patients with mitral stenosis were determined as follows: Cath-MVA=0.967±0.289cm² 2DE-MVA=1.202±0.519 cm², PHT-MVA=1.006±0.364 cm², and ED-MVA=0.976±0.279cm² 2) ED-MVA of these 28 cases correlated well at a coefficient of 0.867 than with PHT-MVA (r=0.513) or 2DE-MVA (r=0.513) in comparison with Cath-MVA, 3) Excluding four patients with mitral regurgitation, the ED-MVA of 24 patients with isolated mitral stenosis showed a better correlation with r=0.944 than with PHT-MVA (r=0.642) or 2DE-MVA (r=0.637) in comparison with Cath-MVA. Therefore, new Echo/Doppler method was a useful noninvasive method in the estimation of mitral valve area with simplicity and accuracy.
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한국인에서 심바스타틴의 효과와 부작용 분석을 위한 다기관 공동 임상 연구
박영배 ( Young-Bae Park ),서정돈 ( Jung-Don Seo ),배종화 ( Jong-Hwa Bae ),노영무 ( Young-Moo Rho ),이원로 ( Won-Ro Lee ),손민수 ( Min Soo Son ),채성철 ( Shung-Chull Chae ),김권삼 ( Kwon-Sam Kim ),김권배 ( Kwon Bae Kim ),안정천 ( J 대한내과학회 1999 대한내과학회지 Vol.57 No.5
The aim of this study was to investigate the efficacy of simvastatin to improved lipid profiles in hypercholesterolemic Korean patients. Methods : From 25 hospitals in Korea, 478 hypercholesterolemic patients were enrolled from November 1996 to April 1998. The inclusion criteria was hypercholesterolemia over 240 mg/dl after diet therapy for 1 month or hypercholesterolemia over 220 mg/dl in patients with definite evidence of ischemic heart disease. Simvastatin 10mg was started and doubled up to 40mg if total cholesterol level remained higher than 200 mg/dl at monthly check. Of 478 subjects, 344 patients in whom study protocol was not violated were analyzed. Results : Male to female ratio was 27:73 and 47% of the subjects were in 6th decade. Hypertension, coronary artery disease, and diabetes mellitus were present in 30, 10, and 4% of the subjects. Baseline lipid profile (mean of total cholesterol-LDL-HDL-triglyceride mg/dl) was 274-185-52-188. The dose of simvastatin for 3 months was 10/10/10mg in 61% of subjects, 10/20/20mg in 21%, 10/10/20mg in 7%, and 10/20/40mg in 12%. The change of total cholesterol level(before-4wk-8wk-12wk-withdrawal 4wk) was 274-209- 205-198-250, and the maximal reduction rate was 27%. The change of LDL-cholesterol was 185-123-116-110-159, with maximal reduction rate 39%. The change of HDL-cholesterol was 52-54-56-55-54, with maximal increase rate 9%. The change of tryglyceride was 188-161- 164-162-189, with maximal reduction rate 15%. The value before/after treatment of ApoA1, ApoB, and Lp(a) was 129/129, 138/83, and 9.3/10.7, respectively. The level of LDL-cholesterol at the end of treatment was below 100mg/dl in 36% of subjects, 100-130 in 45%, 130-160 in 16%, and over 160mg/dl in 4%. The reduction rate of LDL-cholesterol was different between subjects whose LDL decreased below 100 and those whose LDL did not decrease below 130mg/dl, which suggests the existence of the individual difference of responsiveness to simvastatin. There were only 3 subjects (0.9%) who showed increase of liver enzyme over 3 times as the upper normal limit. Conclusion: Simvastatin is effective in improving lipid profiles in hypercholesterolemic Korean patients without serious side effects. (Korean. J. Med 57:906-915, 1999)
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우리나라 뇌졸중의 최근 10 년간 변화 양상에 대한 연구
송일한(Il Han Song),오동환(Dong Hwan Oh),강흥선(Heung Sun Kang),조정휘(Chung Whee Choue),김권삼(Kuen Sam Kim),김명식(Myung Shick Kim),송정상(Jung Sang Song),배종화(Jong Hwa Bae) 대한내과학회 1992 대한내과학회지 Vol.43 No.5
N/A Background: Stroke is well known one of the major causes of death in adults. In the incidence of type of stroke, the cerebral infarction occured more frequently than the cerebral hemorrhage in the Western, but the incidence varies with the individual clinical studies in Korea. We expect that there is changing pattern in the incidence of type of stroke during the recent 10 years in Korea. Methods: To investigate the changing pattern of stroke during the recent 10 years, 1304 patients with stroke who underwent the computerized tomographic scanning were evaluated for the type of stroke, the sex and age distribution, the underlying diseases and the location. Group I included 450 pateints with stroke who admitted from January 1978 to October 1981, at department of internal medicine, Kyung Hee University Hospital. Group II included S54 patients with stroke who admitted from January 1989 to December 1989. Results: Cerebral hemorrhage was the most frequent type of stroke in group I, but cerebral infarction in group II. Male was more prevalent than female in cerebral hemorrhage and cerebal infarction in both groups. The subarachnoid hemorrhage more frequently occurred in female than in male. It was a tendency to increase the frequency in females in group II including all types of stroke. Cerebral hemorrhage occurred most frequently in sixth decade in both groups, but cerebral infarction occurred most frequently in sixth decade in group I and seventh decade in group II. In both groups, hypertension was the most frequent associated disease. The proportion of diabetes mellitus and heart diseases increased in group II than group I. The level of serum total cholesterol in patients with cerebral infarction was higher than those with cerebral hemorrhage in group II. In cerebral infarction, the most frequent lesion site was lobal area. In cerebral hemorrhage, basal ganglia was the most frequent lesion site, the second was thalamus and then subcortical area. Conclusions: These results suggest that the cerebral infarction is the most frequent type in the stroke in Korea recently due to increased population with old age, increased incidence of diabetes mellitus and heart diseases, the adequate control of hypertension and changes of life style and diets.
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관동맥이 완전폐쇄된 환자에서 측부순환과 99mTc - MIBI 심근 SPECT 소견 비교
손경환(Kyung Hwan Son),김권삼(Kown Sam Kim),이무열(Moo Yel Lee),이원호(Won Ho Lee),김덕윤(Deog Yoon Kim),강흥선(Heung Sun Kang),조정휘(Chung Whee Choe),김명식(Myung Sik Kim),송정상(Jung Sang Song),배종화(Jong Hwa Bae) 대한내과학회 1997 대한내과학회지 Vol.53 No.1
N/A Objectives: The role of coronary collateral circulation in protecting myocardium after the occlusion of a supplying artery has long been debated. Recent date show that the coronary collateral circulation may partially prevent ischemia and preserve myocardial contractile function. The purpose of this study was to evaluate the relation between the grades of collateral circulation and perfusion scores of 99mTc-Heart SPECT in patients with totally coronary occlusion. Methods: We studied 44 patients with totally coronary occlusion who had been hospitalized at Kyung Hee University hospital between October, 1989 and May, 1994, Patients were classified into two groups; Group 1: patients with angina pectoris (n=21), Group 2: patients with myocardial infarction (n=23). Angiographic collateral circulation was graded from 0 to 3: 0=none, 1=filling of side branch only, 2=partial filling of the epicardial segment, 3=complete filling of epicardial segment. The perfusion score of dipyridamole stress 99mTc-MIBI Heart SPCET was analyzed with angiographic findings. Resting and stress echocardiography were analyzed to identify left ventricular wall motion abnormalities. Results: 1) When LAD was totally occluded, there were hishevcrgree of collateral circulations from RCA in group 1 and group 2. When RCA was totally occluded, there was higherdesree of collateral circulation from LAD in group 1 and group 2. 2) The degree of collateral development was higher in group 1 than in group 2 (2.5±0.7 vs. 1.8±1.0, p<0.05). 3) In 99mTc-MIBI Heart SPECT, there was no significant difference of perfusion score at stress but perfusion score was significantly higher in group I than in group 2 at rest. 4) In 99mTc-MIBI Heart SPCET, there was no difference of perfusion score between totally coronary occlusion territories in group 1 and more than 50% coronary artery stenotic territories in group 1 and group 2. 5) In stress echocardiography, ten of the 13 patients showed normal LV wall motion at rest, but 9 of these 10 patients showed LV wall motion abnormalities at stress in group l. In group 2, all 10 patients showed LV wall motion abnormalities at rest and 3 of these patients showed more aggravation of LV wall motion abnormalities. Conclusion: Collateral circulation in angina patients can prevent myocardial ischemia and preserve myocardial function at rest, but not at exercise. Collateral circulation in patients with myocardial infarction cannot preserve myocardial function at rest. and exercise. Dipyridamole stress 99mTc-MIBI Heart SPECT is one of the indirect quantification methods to evaluate collateral development and coronary flow reserve.
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한국인에서 경동맥 경화와 관상 동맥 질환의 연관 관계에 관한 연구
이상억(Sang Eog Lee),김권삼(Kwon Sam Kim),김병준(Byoung Joon Kim),이효정(Hyo Jung Lee),안우석(U Seouk Ahn),강흥선(Heung Sun Kang),조정휘(Chung Whee Choue),김명식(Myung Shick Kim),송정상(Jung Sang Song),배종화(Jong Hwa Bae) 대한내과학회 1996 대한내과학회지 Vol.51 No.6
N/A Objectives: Along with the recent change in lifestyle in Korea, the incidence of coronary artery disease(CAD) and cerebrovascular disease due to atherosclerosis has increased. B-mode ultrasound of the extracranial carotid arteries offers a valid and repeatable noninvasive method for quantifying the extent of atherosclerosis. The extent of carotid artery atherosclerosis as measured by B-mode ultrasound has been shown to be strongly and independently correlated with the presence or absence of CAD. We investigated the relation between carotid atherosclerosis and the status of CAD in Korean population with a carotid B-mode ultrasound. Methods: One hundred twenty eight patients underwent. B-mode ultrasound of the carotid arteries with 10 MHZ linear array probe. The intima-media thickness(IMT) at two sites in far(posterior) wall of the both common carotid artery and bifurcation were quantified and evaluated for the incidence of softand hard plaques. Coronary angiography was performed by the percutaneous technique using Judkins catheter. The extent of CAD was counted as 0,1,2,3-vessel disease according to the number of major coronary vessels with an obstruction of 50% or greater. Results: The number of coronary artery involved was single-vessel disease in 41, two-vessel disease in 19, three-vessel disease in 25 and no corona atherosclerotic disease in 43. The incidence of plaques was no CAD group in 10(23%) at the bifurcation, whearas CAD group in 18(23%) at the common carotid artery and 68(80%) at the bifurcation. The incidence of plaques at the bifurcation increased progressively in each of 2- and 3-vessel disease group compare with the 1-vessel disease group(89%, 100% vs 64%). The sum of IMT at both common carotid artery and bifurcation was significantly different between no CAD and CAD group(3.17±0.08mm vs 4.26±1.37mm, p<0,05), and increased progressively in each of the groups with increasing numbers of stenosed vessels(2-vessel clisease:4.98±1.28mm, 3-vessel disease: 5.29±1.20mm Conclusion: The results suggest that increased IMT of carotid arteries is closely related to status and extent of CAD Also measurement of IMT may be useful screening method for assessment of CAD and systemic atherosclerosis.
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等力性과 等長性 運動選手에 있어서 持續的 運動이 心臟의 形態 및 機能에 미치는 效果에 關한 硏究
陳世眞,裵鍾華,朴淳永 慶熙大學校 1990 論文集 Vol.19 No.-
To assess cardiac structure and function in sustained exercise of two different training modes, 32 subjects were studied. Matched 10 healthy Young men(Control group), 12 isotonic exercise athletes of 12 soccers(Group 1) and 10 isometric exercise weight lifters(Group 2) were evaluated by echocardiography at resting state and at maximal exercise state. The following results were obtained. 1. In isotonic exercise Group 1 of resting state, significantly increased left ventricular mass due to significantly increased diastolic left ventricular dimension and left ventricular dimension and left ventricular end-diastolic volume than controls of resting state. 2. In isometric exericise Group 2 of resting state, significantly increased left ventricular mass was due to not only increased diastolic left ventricular dimension and left ventricular end-diastolic volume but also increased septal wall thickness than controls of resting state. 3. Fractional shortening, ejection fraction, systolic velocity integral and peak acceleration were increased significantly in both isotonic and isometric exercise groups of resting state than controls of resting state. 4. Even though there were no changes in diastolic left ventricular dimenion and left ventricular end diastolic volume between isotonic and isometric exercise groups of resting state, systolic left ventricular dimension and left ventricular end-systolic volume were significantly decreased in isometric exercise group of resting state. Fractional shortening ejection fraction and peak acceleration were significantly increased in isomeric exercise group of resting state than isotonic exercise group of resting state. Moreover, the increment of septal wall thickness was greater in isometric exercise group of resting state than in isotonic exercise group of resting state. 5. In isotonic exercise group of maximal exercise state, left ventricular end-systolic volum and end-diastolic volume were significantly increased than controls of maximal exercise state. There were significant increases of diastolic left ventricular dimension and left ventricular end-diastolic volume in isometric exercise group of maximal exercise state than in controls of maximal exercise state, but there was no change of left ventricular end-systolic volume between those two groups. The left ventricular wall thcikness was mostly increased significantly in isometric exercise, group of maximal state than in controls of maximal exercise state. 6. Fractional shortening and ejection fraction were significantly increased in isometric exercise group of maximal exercise state than controls of maximal exercise state. 7. There were significant decrease of left ventricular dimensions and volumes, and significant increase of fractional shortening, ejection fraction and peak acceleration in isometric exercise group of maxmal exercise state than isotonic exercise group of maximal exercise state. In conclusion, isotonic exercise caused increased left ventricular dimension and increased myocardial contractility, whereas isometric exercise caused increased left ventricular dimension, wall thickening and myocardial contractility. At maximal exercise state, isotonic exercise showed more increased ventricular dimension with increased left ventricular wall thickness and myocardial contractility.
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