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배선호(Bai, Sun-Ho),김철(Kim, Chul) 대한생리학회 1975 대한생리학회지 Vol.9 No.1
뇌 해마가 전기충격에 의한 내력(tolerance)에 미치는 영향을 구명하기 위하여, 두정 후두 경계 부위의 대뇌피질을 양측성으로 둥글게 떼어내고, 이를 거쳐 해마를 평균 97%가량 떼어버린 흰쥐(해마군) 14마리와 해마를 덮는 대뇌피질 부분만을 떼어버린 흰쥐(대뇌피질 대조군) 17마리 및 두개골을 노출하는데 그치고 뇌에 손상을 주지 않은 흰쥐(정상 대조군) 17마리를 사용하여 다음과 같은 실험을 실시하였다. 24시간 동안 먹이 없이 물만으로 지나게 한 다음 구금판에 세 무리를 구금하고 24시간 동안 매회 1.5초 동안씩 계속되는 4mA의 교류전류에 의한 충격을 1분 간격으로 반복하여 폐사하는 동물의 수효를 세어 다음과 같은 결과를 얻었다. 1. 전기충격을 가하는 동안 폐사한 동물의 수효에서 해마군의 값은 두 대조군의 값에 비하여 유의하게 적었으나, 두 대조군 사이에는 이렇다 할 차가 없었다. 2. 전기충격으로 인하여 폐사한 예에서 전기충격의 시작부터 폐사할 때까지의 시간은 해마군의 값이 두 대조군의 값에 비하여 연장된 경향을 보여 주었다. 이상의 결과로 미루어 뇌 해마는 전기충격에 대한 내력(耐力)에 억제적 영향을 끼친다고 추리된다. A study was designed to clarify the influence of the hippocampus upon tolerance by electric shock. Forty-eight male rats were used, of which 14 rats had their hippocampal tissue on both sides removed through an opening in the parieto-occipital cortex (hippocampal group), 17 rats received damage to the parieto-occipital cortex only (cortical control group), and 17 rats served as normal control animals. After 24 hours fasting with water ad libitum, each animal was restrained on a plate with added electric shock (4 mA A.C., 1.5 sec in a duration, and once per minute in average) to the tail for the last 24 hours without food and water. The mortality in each animal group and the mean survival time of the dead animal during the repitition of electric shock were calculated. Results obtained were as follows: 1. The mortality was lower significantly in the hippocampal group than in the two control groups. 2. The mean survival time of the dead animal was longer insignificantly in the hippocampal group than in the two control groups. The inference from the above results is that the hippocampus exerts a inhibitory influence upon tolerance by electric shock.
자율신경계에 작용하는 약물이 위장 전기도에 미치는 영향
김명석,박형진,배선호,최현,김철,Kim, Myung-Suk,Park, Hyoung-Jin,Bai, Sun-Ho,Choi, Hyun,Kim, Chul 대한생리학회 1980 대한생리학회지 Vol.14 No.2
In order to investigate the effect of cholinergic substance on the electrical and the mechanical activities of the stomach muscle, 10 isolated cat stomachs were studied. At various sites of a stomach muscle preparation, the electrical activity was monopolarly recorded by using capillary electrodes containing chlorided silver wires, and the isometric contractile activity was recorded simultaneously at the terminal portion of the antrum in Krebs solution$(36^{\circ}C)$ which was aerated with a gas mixture consisting of 95% $O_2$ and 5% $CO_2$. The recording of these activities were performed before (control period) and after acetylcholine$(10^{-5}M)$ and atropine $(10^{-6}M)$ administrations serially. Following results were obtained: 1) The mean frequency of the slow wave was $4.36{\pm}0.22\;cycles/min$ at all the various sites of the cat stomach. The slow wave was propagated caudad in sequence and its velosity of propagation increased as the slow wave approached the pylorus in normal Krebs solution. 2) After acetylcholine administration, the frequency of the slow wave increased transiently and the increase of slow wave frequency was followed by the isometric contraction of antral muscle in association with the second potential which succeeded the slow wave. 3) By atropine administration, the stimulatory effect of acetylcholine on the antral muscle contraction was abolished completely, and the frequency of the slow wave decreased significantly compared with that of the control period, which tendency was more prominent in the antrum. The above results suggest that the transient increase in the frequency of gastric slow wave by acetylcholine may have some influence upon the contraction mechanism of the cat antral muscle.
할라이드의 $S_N2$ 형 반응성에 미치는 술페닐, 술피닐 및 술포닐기의 효과에 대한 확장 Huckel 계산
김의락,이규용,배선호,이익춘,Ui Rak Kim,Kyu Yong Lee,Sun Ho Bai,Ikchoon Lee 대한화학회 1974 대한화학회지 Vol.18 No.1
확장 Huckel법을 사용하여 술페닐, 술피닐 및 술포닐기가 할라이드의 $S-N2$형 반응에 미치는 효과를 고찰하고 각종 반응성 지수를 비교, 검토한 결과 bond formation과정의 반응성 지수중 Frontier electron에 의한 것이 가장 합리적인 것임을 밝혔다. Extended Huckel calculations have been carried out to study the effect of sulfenyl, sulfinyl and sulfonyl groups on the reactivity of halides in $S-N2$ reactions. Results indicate that the most reasonable reactivity index is that based on the Frontier electron for the bond formation process.