성인 아토피피부염 환자의 성격특성에 관한 연구

방형돈 ( Hyeong Don Bang ),안필수 ( Phil Soo Ahn ),김규한 ( Kyu Han Kim ),박경찬 ( Kyoung Chan Park ),권준수 ( Jun Soo Kwon ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.3

Background: Atopic dermatitis will persist into adult life and chronic severe atopic dermatitis may cause significant interference in social interaction. Despite the controversy concerning the existence of specific personality exhibited by patients with atopic dermatitis, psychological and social factors have long been considered important factors that have influence on the course of the disease. Objective : The purpose of this study was to investigate the charateristics of the personalities of adult patients with atopic dermatitis and their relationship to psychological factors and clinical characteristics. Methods : Eysenck Personahty Questionnaire(EPQ) was carried out on 54 adult patients with atopic dermatitis. Using the EPQ scores, a cluster analysis was done to identify the subgroup of psychologically disabled patients. The psychological and social aspects of the identified patients were then investigated using a designed questionnaire. Results : 1. A cluster analysis identified two patient subgroups. Psychoticism(P), extroversion-introversion(E), and neuroticism(N) scores were significantly different between the subgroups. The neuroticism scores were above the upper limit of the normal range in the higher EPQ scored subgroups. However, the total clinical severity score which was evaluated in 25 patients showed no significant difference between these subgroups. 2. The higher psychoticism, extroversion-introversion, and neuroticism scored patients tended to express severe disability due to atopic dermatitis and a high level of stress which was evaluated by the designed questionnaire. Conclusion : Eysenck personality questionnaire can be helpful in identifying a subgroup of patients who may need psychiatric intervention. (Kor J Dermatol 1996;34(3): 359-365)

Allopurinol 과민증후군 3예

방형돈(Hyeong Don Bang),정진호(Jin Ho Chung),조광현(Kwang Hyun Cho),윤재일(Jai Il Youn) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

The allopurinol hypersensicivity syndrome is a rare, but life thereaning immunologic reaction of allopurinol therapy, characterized by multiple abnormalities such as fever, rash, decreased renal function, hepatocellular injury, leukocytosis, and eosinophila. It may require prolonged hospitalization and occasionally involves residual morbidity. Three patients developed erythematous skin eruption three to five weeks after beginning therapy with allopurinol. The clinical, laboratory, and histologic findings of these patients were compatible with a allopurinol hyperensitivity syndrome. (Kor J Dermatol 1995; 33(1): 130-134)

아토피피부염에서 진드기 항원에 대한 말초 혈액 단핵구 세포 증식 반응과 피부의 즉시형 과민반응의 상관관계

김규한(Kyu Han Kim),방형돈(Hyeong Don Bang),정진호(Jin Ho Chung),박경찬(Kyoung Chan Park) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.2

Background : House dust mites have been reported to play an aportant role in the pathogenesis of atopic dermatitis(AD). In fact a high positive rate for house dust mites in the skin prick test was observed in patients of AD. However, it is quite difficult to determine the clinical relevance of positive immediate hypersensitivity to mite antigen by clarical history alone because AD patients are nearly always exposed to these antigens in their daily lives. Objective : The aim of this study was to elucidate the clinical. singficance of a positive immediate hypersensitivity reaction by observing the proliferative respons of peripheral blood mononuclear cells(PBMC) to mite antigen in the AD. Methods : The proliferative response of PBMC separated from Dermatopkagoides farinae(Df) positive AD patients to Df antigen was compared with that from Df negative normal controls, Df positive normal controls and Df negative AD patients. Results : PBMC from Df positive AD patients showed signinc not proliferation in response to Df antigen evaluated by comparing stimulation indices(SI) among different experiment groups. Conclusion : Significant correlation between responses of PBMC and immediate hypersensitivity of skin to Df antigen in AD was found, and it was suggested the Df may be a real aggravating factor in the Df positiv AD patients. SI may be used as ar objective criteria to select patients for hyposensitization therapy after doing a skin test. (Kor J Dermatol 1995;33(2): 232-239)

아토피 피부염 환자에서 집먼지 진드기 항원에 대한 Pharmacia CAP system FEIA의 효용성

김성식 ( Kim Seong Sig ),방형돈 ( Bang Hyeong Don ),김광호 ( Kim Gwang Ho ),김광중 ( Kim Gwang Jung ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.11

N/A Barkground : Specific serum IgE determination is widely used in the diagnosis of IgE-mediated allergic diseases. House dust mite allergens are known to show good sensitivity on in vitro tests. We report the results of specific IgE against house dust allergen by Pharmacia CAP system FEIA and compared them with those of in vivo test. Objective : The aim of this study is to find out the clinical application of Pharmacia CAP system FEIA in atopic dermatitis. Methods : In 46 atopic dermatitis patients, skin prick test and Pharmacia CAP system FEIA were performed for Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens. For all patients, atopy and family histories were taken. Results : 1) The positive results were more frequent in adult patients(over 16 years old, 73.3%) than in child patients(below 15 years old, 38.7%) in skin prick test for both Dermatophagoides pteronyssinus and Dermatophagoides farinae allergens. 2) When skin prick tests were used as a reference standard, the sensitivity of Pharmacia CAP system FEIA was 89.5% for Dermatophagoides pteronyssinus and 90.0% for Dermatophagoides farinae, and the specificity of Pharmacia CAP system FEIA was 77.8% for Dermatophagoides pteronyssinus and 80.8% for Dermatophagoides farinae. 3) Correlations were found between Pharmacia CAP system FEIA results and serum total IgE(r=0.574 for Dermatophagoides pteronyssinus and r=0.534 for Dermatophagoides farinae) Conclusion : Our results suggest that Pharmacia CAP system FEIA offers high sensitivity and can be an effective method of screening for allergies to Dermatophagoides pteronyssinus and Dermatophagoides farinae in atopic dermatitis. (Korean J Dermatol 2003;41(11) : 1455∼1462)

아토피 피부염 환자에서 식품 알레르기에 대한 CAP-RAST FEIA와 개방 경구유발시험에 관한 연구

전현진 ( Jeon Hyeon Jin ),방형돈 ( Bang Hyeong Don ),김광호 ( Kim Gwang Ho ),박천욱 ( Park Cheon Ug ),김광중 ( Kim Gwang Jung ),이철헌 ( Lee Cheol Heon ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.8

N/A Background : The role of dietary factors in atopic dermatitis has been the subject of debate for several decades. Recently it has received convincing support from a double-blind controlled trial of an exclusion diet, showing benefit from careful avoidance of egg and milk in a group of atopic children. Object : The purpose of this study was to determine the prevalence of specific food allergies in Korean atopic dermatitis and the potential utility of the Pharmacia CAP-RAST FEIA in the diagnosis of food allergy. Methods : One hundred ten patients with atopic dermatitis were evaluated for food hypersensitivity by history, skin prick test, CAP-RAST FEIA, and open food challenge test(OFCT). Results : 1) The prevalence of specific food allergies in the study population was 28.2% in history and 18.2% in CAP-RAST FEIA and OFCT. 2) The frequent food allergens were milk, egg, peanut, and wheat. 3) There was no correlation between the clinical severity of atopic dermatitis and CAP-RAST FEIA and OFCT results. 4) Plasma eosinophil and IgE levels were correlated with CAP-RAST FEIA results, but not OFCT results. 5) According to the history, 31 atopic dermatitis patients answered that their dermatitis was related to food, and of the 31 patients, positive reactions to prick test and CAP-RAST FEIA were observed in 8 and 22 patients, respectively. Among the other 79 patients who answered that there was no relation between atopic dermatitis and food, 14 patients reacted positively to prick test and 47 patients showed positive result to CAP-RAST FEIA. Conclusion : The CAP-RAST FEIA provides standardized measurement of food specific IgE antibodies which may be useful to diagnose food allergy in atopic dermatitis. (Korean J Dermatol 2003;41(8) : 1034~1040)

심재성 연소성 황색육아종

류정호 ( Jeong Ho Ryu ),방형돈 ( Hyeong Don Bang ),김광호 ( Kwang Ho Kim ),김광중 ( Kwang Joong Kim ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4

Juvenile xanthogranuloma(JXG) is a disorder of histiocytes usually associated with cutaneous lesions. JXG developing in soft tissue is rare and receives little attention. Therefore deeply located JXG may present a diagnostic difficulty in the absence of cutaneous lesions. Clinically, deep JXG seems to occur as solitary lesions on the trunk rather than on the head and neck region and tends to be composed of a monotonous population of histiocytic cells, with rare, if any, foamy macrophages or Touton-type multinucleated giant cells. We report an unusual case of JXG in a 4-month-old male infant who had a deep-seated mass located on the subcutaneous and muscle layer of the left forearm. (Korean J Dermatol 2003;41(4) : 479-483)

피부이식부위에서 발생한 이영양성 피부 석회증 1 예

전현진(Hyun Jin Jeon),김경일(Gyeong Il Kim),방형돈(Hyeong Don Bang),김광중(Kwang Joong Kim) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.8

Calcinosis cutis is the deposition of calcium phosphate into the skin. It is classified as dystrophic if the calcium is deposited in previously damaged tissue and serum calcium and phosphorous levels are normal. We report a case of dystrophic calcinosis cutis in a 35-year-old man. About 2 months ago, he developed an ulcer in the left thigh that was treated by grafting. Histopathologically, amorphous basophilic materials that stained with von Kossa were deposited in the dermis. (Korean J Dermatol 2001;39(8)918-920)

중증근무력증 환자에서 발생한 전신성 농포성 건선

류정호 ( Jeong Ho Ryu ),전현진 ( Hyun Jin Jeon ),방형돈 ( Hyeong Don Bang ),김광호,김광중 대한피부과학회 2003 대한피부과학회지 Vol.41 No.3

Generalized pustular psoriasis(GPP) is an uncommon and severe form of psoriasis. The possible provocative factors such as steroid therapy, infection, stress, drugs, pregnancy, sun exposure, and metabolic disorders were reported. Among them, corticosteroid

피부 전이를 보인 남성 유방암 1예

전진곤,방형돈,김광호,김광중 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.5

Male breast cancer is a rare disease, accounting for approximately 1% of all breast cancer. We report a case of cutaneous, osteolytic, pulmonary, and hepatic metastases of male breast cancer in a 40-year-old male who presented 4 × 2.5 ㎝ erythematous plaque with ulceration and bloody discharge on the areolar area of the left anterior chest. The histopathologic findings of the lesion showed nests and strands of invasive carcinoma forming ductlike structures and cellular arrangement in single-row line, referred to as Indian filing, between collagen bundles. The tumor cell showed positive reaction for estrogen receptor, but negative reaction for progesterone receptor. He was treated with tamoxifen, 5-fluouracil, adriamycin, and cyclophosphamide. Six months after initiation of the treatment, skin lesion was improved. Also, number and size of the metastatic cancer nodules decreased in the computer tomographic imaging. (Korean J Dermatol 2003;41(5) : 660~663)

성대마비를 동반한 Ramsay Hunt 증후군 1예

전현진,방형돈,김광호,김광중 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.4

Ramsay Hunt syndrome or herpes zoster oticus is a viral disease associated with otalgia, vesicuTar eruption, facial paralysis, hearing disturbance, tinnitus, vertigo and other symptoms. Rarely it can be associated with involvement of Ⅳ, Ⅴ, Ⅸ, Ⅹ, XI, XII cranial nerves, cervical plexus, and diffuse encephalitis. We report a case of Ramsay Hunt syndrome with vocal cord paralysis which developed prior to facial nerve paralysis. (Korean J Dermatol 2003;41(4) : 507~509)