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혈관육종 26예와 카포시육종 26예의 생존율과 예후 인자: 한국 단일기관 연구
방진선,하남경,이인희,한만훈,이정은,정호윤,하대룡,이석종 대한피부과학회 2023 대한피부과학회지 Vol.61 No.8
Background: Angiosarcoma (AS) and Kaposi sarcoma (KS) are rare malignant and borderline malignant vascular tumors that may first present to a dermatologist. There are few Korean studies that particularly focus on their survival due to low incidence. Objective: To investigate the survival and prognostic factors among patients with AS and KS, in addition to their clinical features. Methods: Between 2000∼2021, medical records of 26 AS and 26 KS patients at a single center were analyzed retrospectively. Additionally, we calculated the disease specific survival (DSS) and overall survival (OS) of two diseases. Results: The mean age of patients with AS was 72.9 years and 67.3 years for KS. The most common tumor location was the scalp in patients with AS (80.8%) and the foot (65.4%) in those with KS. In patients with AS, 1-year DSS and OS rates were 36.0% and 34.6%, respectively. Five-year DSS and OS rates were 24.0% and 20.2%, respectively. In patients with KS, the 1-year DSS and OS rates were 96.2% and 84.6%, respectively. The 5-year DSS and OS were 91.6% and 58.0%, respectively. Patients who were older or had larger lesions than average had decreased DSS and OS in AS. Among the patients with KS, immunosuppressed status, including human immunodeficiency virus infection, showed reduced OS. Conclusion: Apart from confirming grave survival of AS and favorable survival of KS, patient’s age and size of lesion affect survival outcomes in patients with AS. Otherwise, immunosuppressed status affects survival outcomes in patients with KS.
방진선 ( Jinsun Bang ) 사단법인 아시아문화학술원 2020 인문사회 21 Vol.11 No.6
뮤지엄은 다양한 경험을 보유한 사람들이 모여 영감을 받고 창의성을 키우며 살아 있는 배움이 있는 특별한 공간으로서 이미 우리 일상 속으로 깊이 들어와 있다. 4차 산업혁명과 COVID-19로 인해 산업의 패러다임과 사회 전반이 변화하고 뮤지엄 회복에 대한 논의가 활발히 이루어지고 있다. 본 연구는 위기의 시대에 민간 기업이 운영하는 기업뮤지엄을 사례로 뮤지엄의 정체성과 역할, 그리고 평생 학습적 가능성을 확인하고자 하였다. 기업뮤지엄의 주된 역할은 교육적 소외를 해소하는 포용의 공간이자 가능성의 공간으로 기능하는 것이며 새로운 경험을 재생산하고 자아실현과 시민의 문화욕구를 채워주는 기능을 발견할 수 있었다. 그리하여 기업뮤지엄이 사회적 책임을 바탕으로 지속적인 발전이 가능한 학습을 추구하고 개개인이 평생학습자로서 성장하도록 견인하며 양질의 교육을 공유하고 작은 학습사회를 만들어가는 평생학습의 동반자임을 확인하였다. 본 연구 결과를 바탕으로 지역사회 발전을 위한 강력한 문화자산이자 평생교육의 핵심 기관인 기업뮤지엄의 평생 교육적 의미를 더욱 살려, 더욱 구체적인 개별 연구 주제로 후속 연구가 이어지기를 기대한다. A museum has become a part of our lives as a special space where people with diverse experiences come to get inspiration, foster creativity, and learn new things. Due to the 4th Industrial Revolution and COVID-19 are changing the industrial paradigm and discussions on the restoration of museums are actively taking place. This study examined the identity, role, and potential for lifelong learning of corporate museums managed by private companies in an era of increasing uncertainty. The main role of corporate museums is to function as a place of embracement and possibility where educational marginalization is eased, helping reproduce new experiences, promote self-realization, and satisfy citizens' cultural needs. Therefore, it was found that a corporate museum is a lifelong learning partner that pursues sustainable learning, leads individuals to grow as a lifelong learner, provides quality education, and creates a small learning society based on social responsibility. In addition, this study suggests that we need to consider museums beyond their forms and formal divisions of museums in order to recognize their role in improving the quality of personal life as a strong cultural asset and an important institution of lifelong education for the development of local communities.
하대룡,방진선,정지윤,한만훈,이석종 대한피부과학회 2023 대한피부과학회지 Vol.61 No.2
Lymphomatoid papulosis (LyP) is a relatively uncommon CD30+ lymphoproliferative disorder with a goodprognosis. However, it is important to be cautious because 4%∼25% of the cases are accompanied by secondarylymphoma. LyP is divided into subtypes of infiltrate-descriptive categories based on the histological findings. Classically, LyP shows a patchy, wedge-shaped, dermal infiltrate of small to intermediate-sized lymphocytes, withatypical lymphoid cells and a variable mixture of neutrophils, histiocytes, and eosinophils. Follicular LyP (type FLyP), which was recently described and is not yet included as an official subtype in the World Health Organizationclassification, shares these characteristics, although its infiltrate is folliculocentric. Variable folliculotropism, folliculardilation, rupture, and mucinosis can occur. This entity is commonly misdiagnosed and is possibly underreportedbecause its histopathologic features can masquerade as more common follicular-based entities. Herein, we report thecase of follicular type LyP, which has not been reported in in Korean dermatology literature.
한태영,심동현,이유진,이영복,구하예린,신민경,김태은,장용현,방진선,국형돈,안지영,정혜정,나찬호 대한피부과학회 2023 Annals of Dermatology Vol.35 No.1
Background: Atopic dermatitis (AD) patients usually wonder if their condition will worsenafter vaccination or if they should continue with the treatment they are receiving. Consideringthat many patients treated with dupilumab had previously experienced severe ADsymptoms and flares, the concerns are more understandable. Objective: This study aimed to investigate the safety of the coronavirus disease 2019 (COVID-19) vaccination in patients with AD treated with dupilumab. Methods: We enrolled 133 patients (101 dupilumab-treated and 32 systemic oral agentstreatedas control group) with AD from six hospitals. Patients were asked about worseningpruritus and AD (5-point Likert scale) after vaccination. AD variables (eczema area and severityindex [EASI], investigator’s global assessment [IGA], itch numerical rating scale [NRS],sleep NRS, and patient-oriented eczema measure [POEM]) were compared pre- and postvaccination. Adverse reactions to the COVID-19 vaccination were observed. Results: The incidence of adverse reactions to COVID-19 vaccines and worsening ADsymptoms in dupilumab-treated patients were not significantly different compared with thatin the control group. The itch NRS score increased significantly after vaccination (p<0.001). However, there were no statistically significant differences between the pre-and post-EASI,IGA, and POEM scores. Eight patients (7.9%) had worse EASI scores and required rescuetherapy; however, most were easily managed with low-dose steroids or topical agents. Noneof the patients discontinued dupilumab treatment. Conclusion: No serious adverse reactions were observed in patients with AD after COVID-19 vaccination. Exacerbation of pruritus and AD symptoms was observed but wasmostly mild and transient.