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박형욱,정준,Kamran Behdinan,이재우 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.6
In recent years, high-fidelity analysis tools, such as computational fluid dynamics and finite element method, have been widely used inmultidisciplinary design optimization (MDO) to enhance the accuracy of design results. However, complex MDO problems have manydesign variables and require long computation times. Global sensitivity analysis (GSA) is proposed to assuage the complexity of designproblems by reducing dimensionality where variables that have low impact on the objective function are neglected. This avoids wastingcomputational effort and time on low-priority variables. Additionally, uncertainty introduced by the fidelity of the analysis tools is consideredin design optimization to increase the reliability of design results. Reliability-based design optimization (RBDO) and possibilitybaseddesign optimization (PBDO) methods are proposed to handle uncertainty in design optimization. In this paper, the extended Fourieramplitude sensitivity test was used for GSA, whereas a collaborative optimization-based framework with RBDO and PBDO wasused to consider uncertainty introduced by approximation models. The proposed method was applied to an aero-structural design optimizationof an aircraft wing to demonstrate the feasibility and efficiency of the developed method. The objective function was to maximizethe lift-to-drag ratio. The proposed process reduced calculation efforts by reducing the number of design variables and achieved the targetprobability of failure when it considered uncertainty. Moreover, this work evaluated previous research in RBDO with MDO for the wingdesign by comparing it with the PBDO result.
박형욱 대한의용생체공학회 1996 의공학회지 Vol.17 No.4
In this paper, we analyzed the coil-magnet type vibrating transducer for the implantable middle ear hearing aid which is appropriate for patient's hearing level, and an experimental transducer system is designed For the objective and quantitative analysis of the transducer, a theoretical equivalent model containing coil, magneto and inner ear is developed To perform effective evaluation of the transducer, a transforming ratio Tr is introduced and its range that is suitable for practical implantable middle ear hearing device is foun4 The result of applying physical parameters of ear system to the proposed analytical model shows that frequency response of the coil magrlet type vibrator is predominantly governed by resistive impedance of the coil rather than inertia effect of the magnet and the inner parameters. In addition, we realized an experimental middle ear hearing aid system to show the theoretical validity of designed system and this will provide the basis of the development for actually implantable system.
효율적 분산협동최적설계를 위한 병렬처리 기반 분해 기법
박형욱,김성찬,김민수,최동훈,Park, Hyeong-Uk,Kim, Seong-Chan,Kim, Min-Su,Choe, Dong-Hun 대한기계학회 2001 大韓機械學會論文集A Vol.25 No.5
In practical design studies, most of designers solve multidisciplinary problems with large size and complex design system. These multidisciplinary problems have hundreds of analysis and thousands of variables. The sequence of process to solve these problems affects the speed of total design cycle. Thus it is very important for designer to reorder the original design processes to minimize total computational cost. This is accomplished by decomposing large multidisciplinary problem into several multidisciplinary analysis subsystem (MDASS) and processing it in parallel. This paper proposes new strategy for parallel decomposition of multidisciplinary problem to raise design efficiency by using genetic algorithm and shows the relationship between decomposition and multidisciplinary design optimization (MDO) methodology.
The Influence of Botulinum Toxin Type A on Masticatory Efficiency
박형욱,권정승,김성택,최종훈,안형준 대한안면통증∙구강내과학회 2013 Journal of Oral Medicine and Pain Vol.38 No.1
This study was aimed to evaluate the masticatory efficiency after botulinum toxin type A (BTX-A) injection during 12 weeks using objective and subjective test. Also, we compared the difference of masticatory efficiency between group that injected into the masseter muscle only (M-group) and group that injected into the masseter and temporalis muscle (M-T group). The mixing ability index (MAI) was used as the objective indicator, and visual analogue scale (VAS)and food intake ability (FIA) index were used as the subjective indicators. It was concluded that masticatory efficiency was significantly lowered after a BTX-A injection into the masticatory muscle, but it gradually recovered in a predictable pattern by the 12 weeks. The disturbance of subjective masticatory efficiency was lasted longer than objective masticatory efficiency. The masticatory efficiency was lower in M-T group than M group. It was statistically significant in the VAS and FIA at 4 weeks, but the MAI showed no significancy. After 4weeks, there was rapid recovery of muscle function in M-T group, and the difference between two groups was not significant. It could be concluded that there will be no serious disturbance of mastication compared to injection is done only into the masseter muscle, even if injection is done into the masseter and temporalis muscle in dose of this study. According to the food properties, it was confirmed that people feel more discomfort on taking hard and tough foods after BTX-A injection and not only hard foods, but also intake of soft and runny foods were influenced by botulinum toxin injection.
박형욱 대한의사학회 2011 醫史學 Vol.20 No.1
The French surgeon and Nobel laureate Alexis Carrel’s tissue culture has been highly influential in biomedicine. This paper contextualizes Carrel’s works with respect to the birth of gerontology during the first half of the twentieth century. I argue that Carrel contributed to gerontology in several respects. First, using his “immortal” tissues, he asserted that aging was a contingent phenomenon that could be experimentally manipulated. Although this claim was eventually challenged, it prompted many scientists to think that aging was not so much an unavoidable, unidirectional phenomenon as a process amenable to experimental approaches. Second,his research on different culture conditions required by distinct cell types encouraged the idea that the rate and mode of aging differed in distinct parts of the body. This idea became a basis of later gerontologists’ claim that each senior person’s job in industry should be determined according to the degree of senescence shown in his particular body parts. It also helped gerontologists make their field a multidisciplinary arena that could tackle diverse features of senescence occurring in the body. Third, Carrel’s public speeches and appearance in popular media encouraged both scientists and laypeople to think that research on senescence should be pursued more systematically in an era of an increasing elderly population. By analyzing the relation of these issues to the efforts to construct gerontology, this paper illustrates tissue culture’s broader meanings with respect to the emerging concerns about the aging population, the need for continued employment of seniors, and scientists’ hopes for controlling senile processes.