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박현선(Hyun Sun Park),천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 대한약학회 1999 약학회지 Vol.43 No.3
Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and Sangimosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.
5% Imiquimod 크림을 사용한 피부종양의 치료경험
박현선 ( Hyun Sun Park ),최정원 ( Jung Won Choi ),허창훈 ( Chang Hun Huh ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.10
Background: Imiquimod is an immune response modifier that shows antiproliferative and antiviral characteristics through synthesis of multiple cytokines. Although it was originally approved by the FDA for the treatment of genital warts, it has also been successfully used to treat various dermatological conditions. Objective: The aim of this study was to report our treatment experience of cutaneous tumors with 5% imiquimod cream, and to contemplate the effectiveness and safety of its use for purpose. Methods: We reviewed 21 patients with biopsy-proven cutaneous tumors who were treated with 5% imiquimod cream. Data was collected through medical records, clinical photographs, and biopsy specimens. Results: The patients had various cutaneous tumors including actinic keratosis, Bowen`s disease, Bowenoid papulosis, keratoacanthoma, superficial basal cell carcinoma and invasive squamous cell carcinoma. Among 17 patients who were initially treated with 5% imiquimod cream, 13 patients (76.5%) achieved clinical complete re-mission, and histologic cure was also confirmed in four. No recurrence was observed during the follow up period in these 13 patients. While applying 5% imiquimod cream, all the patients experienced local side effects but it was mild and generally well-tolerated. Conclusion: Topical immunotherapy of cutaneous tumors with 5% imiquimod cream has potential as a patient-friendly, well-tolerated therapy that can achieve cosmetically and functionally pleasing treatment outcomes. (Korean J Dermatol 2007;45(10):989∼995)
박현선 ( Hyun Sun Park ),허창훈 ( Chang Hun Huh ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.3
Lymphomatoid papulosis is a lymphoproliferative disorder which is clinically benign but histologically malignant. It is characterized by chronic recurrent self-healing papules or nodules with histologic features suggestive of a malignant lymphoma. An association of lymphomatoid papulosis with other lymphomas including mycosis fungoides, Hodgkin disease and anaplastic large cell lymphoma ranges is present in approximately 10 to 20% of cases. We report a case of lymphomatoid papulosis associated with early mycosis fungoides. (Korean J Dermatol 2008;46(3): 384∼387)
천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),박현선(Hyun Sun Park),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Eye irritation of Sangmosu was evaluated in New Zealand White rabbits. In ocular irritation test, any injury on iris, conjunctival membrane, and cornea was not observed. No injuries of the ocular mucous membrane were also recorded. These results indicate that Sangmosu was not considered to be irritant in test organs of animals.
구인회(Ku In-hoe),박현선(Park Hun-Sun),정익중(Chung Ick-Joong),김광혁(Kim Kwang-Hyuk) 한국사회복지학회 2009 한국사회복지학 Vol.61 No.1
본 연구는 초등학교 4학년에서 6학년에 이르는 3개년에 걸쳐 종단적으로 관찰된 빈곤경험이 학업성취, 자아존중감, 우울?불안, 주의집중 문제, 공격성, 비행에 미치는 영향을 분석하였다. 아동의 빈곤경험을 지속빈곤, 일시빈곤, 비빈곤으로 나눠 발달산물을 비교한 결과, 학업성취에서 빈곤아동과 비빈곤아동 사이의 격차가 두드러지고 통계적으로 유의한 차이를 보였다. 빈곤경험과 발달궤적의 관계를 분석한 결과, 학업성취에서는 비빈곤아동은 시간이 갈수록 성취수준이 향상되는 긍정적 변화방향을 보이나 빈곤아동은 성취수준이 낮아지는 부정적인 변화방향을 보였다. 또 주의집중 문제, 공격성, 비행의 발달궤적 변화에서는 빈곤아동은 비빈곤아동에 비해 다소 낮은 수준을 보였다. 아동의 개인적, 가족적 특성을 통제한 결과 빈곤의 영향은 학업성취에 대해서만 통계적으로 유의하였다. This study analyzes the effect of poverty on child development outcomes including academic achievement, self-esteem, depression/anxiety, attention problems, aggression, and delinquency. The poverty experiences among elementary school children are lognitudinally observed during 3 years between the 4th grade and the 6th grade. When development outcomes are compared among persistently poor children, transitory poor children, and non-poor children, academic achievement is found to be significantly different. The analyses of the relationships between the poverty status and developmental trajectories show that academic achievement among non-poor children has improved over time, while the level of poor children's achievement has decreased. The result also shows that problematic behaviors such as attention problems, aggression, delinquency has improved over time among all the children. Yet, the gap between poor and non-poor children has not decreased. The multivariate analyses indicate that the effect of poverty remains statistically significant only for academic achievement after children's indivisual and familial characteristics are controlled. Past experiences of poverty in addition to the current poverty affect academic achievement and persistent poverty has a stronger effect than transitory poverty on academic achievement, although the findings are not consistent across all the estimated models.
친환경농산물정보시스템 IS특성이 사용의도에 미치는 영향
이동만(Dong-nan Lee),이승훈(Seung-hun Lee),황채영(Chea-young Hwang),박현선(Hyun-sun Park) 한국인터넷전자상거래학회 2009 인터넷전자상거래연구 Vol.9 No.2
The purpose of this paper is to explore factors that influence the performance of Environment Friendly Agricultural Products Information System. It reviewed previous studies related to Technical Acceptance Model and Information System Success Model. It also suggested an empirical model and tested it with Structural Equation Modeling using AMOS-graph based on the survey data of 160 respondents. The major results of this paper are as follows : First, information updated has positive effect on the perceived usefulness and perceived ease of use. Second, system reliability has positive effect on the perceived usefulness and perceived ease of use. Third, service responsive has positive effect on the perceived ease of use. Fourth, perceived usefulness and perceived ease of use have positive effect on intention to use. And results also show that perceived ease of use has positive effect on perceived usefulness.
김대영(Dae Young Kim),최설민(Sul Min Choi),천선아(Sun Ah Chun),박현선(Hyun Sun Park),우동준(Mi Kyung Lee),이미경(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Acute subcutaneous toxicity of Sangmosu was investigated in Sprague-Dawley rats. Seven days after administration of Sangmosu (0.078~20 ml/kg), we examined the clinical signs, mortalities, body weight changes, etc. No clinical signs and mortalities were observed in animals. Any significant change of body weights was not observed. These results suggest that LD50 value of Sangmosu was above 20 ml/kg in Sprague-Dawley rats.
Titanium mesh와 Kaneda 장치를 이용한 흉요추부 불안정 파열골절 환자의 치료 : 증례보고 Cases Report
김은영,윤승환,박형천,박현선 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.2
Anterior decompression and fusion is a valuable technique in the treatment of thoracolumbar burst fractures. Anterior instrumentation has evolved to corret deformity and stabilize the spinal segments during decompression and bone grafting as a single-stage procedure. Anterior instrumentation using Kaneda device and bone fusion with the iliac or fibular bone have popularly performed in many other institutes. Our institutes managed three patients who had unstable burst fractures of the thoracolum- bar spine with a single anterior spinal decomfression. Bone grafting using Titanium mesh tilled with fracture-fragments in anterior spinal reconstruction instead of the iliac or fibular bone and Kaneda spinal instrumentation. All three patients recovered above one Frankel grade after management. And all patients observed a significant improvement of compression height ratio, wedge angle, kyphosis angle on simple lateral X-ray and of canal compromising on spinal computerized tomography. The Titanium mesh constructs provided the greatest resistance to axial load and helped the patients to avoid the complication of donor site. We reports 3 patients with burst fractures in the thoracolumbar spine that satisfactorily recovered radiological and neurological status after managements using Titanium mesh and Kanada device.