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      • KCI등재후보

        농산물 소독과정에서 브롬화메틸에 노출된 근로자에게 발생한 신경병 2례

        박태혁,김정일,손지언,김종국,김형수,정갑열,김준연 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

        목적 : 농산물 소독과정에서 브롬화메틸에 노출된 근로자에게 발생한 신경병 2례 보고. 방법 : 피로감, 전신무력감, 어지럼증, 보행장애 등의 증상을 주소로 내원한 브롬화메틸을 사용하여 방역작업에 종사하는 건강한 20세와 18세의 근로자를 대상으로 혈액검사, 신경정도 및 근전도검사, 뇌자기공명영상 등의 임상검사와 작업력조사를 시행하였다. 결과 : 1례에서 뇌자기공명영상에서 연수와 소뇌의 양측 측충부의 고신호강도가 관찰되었고 11일 후의 추적조사에서 동일 부위의 고신호강토가 감소된 소견이 관찰되었으며 뇌병증으로 최종 진단되었다. 다른 1례는 신경전도검사에서 다발성 신경병 소견과 뇌유발전위검사에서 우측 하부 뇌간부위 병소가 관찰되었고 뇌병증 및 말초신경 병으로 최종 진단되었다. 결론 : 근로자들의 증상은 소독과정에서 브롬화메틸 노출로 인한 신경 병으로 판단되며 훈증소독과방역작업에 종사하는 근로자들의 실태조사와 안전에 대한 대책이 시급하다고 하겠다. Objectives : To report two cases of neuropathy due to methyl bromide intoxication. Methods : Workers, engaged in the fumigating process, complained fatigue, general weakness, ataxia, and hypersomnia. We evaluated them with blood tests, neurophysiologic studies and MRI and investigated their occupational history. Results : Increased signal intensities were found in the medulla oblongata and paraver mian of cerebellum in MRI and after 11 days, high signal intensities were reduced in the following MRI. In the other case, polyneuropathy and rlght lower brainstem lesion were observed In the NCV and BAEP studies. Conclusions : We confirmed that worker's symptoms were related to methyl bromide exposure in the fumigation. It is necessary that we should evaluate present condition of fumigating process and prepare appropriate methods to protect workers engaged in the fumigation.

      • 농산물 소독과정에서 브롬화메틸에 노출된 근로자에게 발생한 신경병 2례

        박태혁,김정일,손지언,김종국,김형수,정갑열,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

        Two Cases of Neuropathy by Methyl Bromide Intoxication during Fumigation Tae Hyuk Park, Jung Il Kim, Ji Eun Son, Jong Kuk Kim*, Hyung Soo Kim**, Kap Yeol Jung, Joon Youn Kim** Department of Occupational Medicine, Neurology*, Dong-A University Hospital Department of Preventive Medicine and Industrial Medicine Research Institude, College of Medicine, Dong-A University** Objectives : To report two cases of neuropathy due to methyl bromide intoxication. Methods : Welters, engaged in the fumigating process. complained fatigue, general weakness. ataxia. and hypersomnia. We evaluated them with blood testy. neurophysiologic studies and MRI and investigated their occupational history. Results : Increased signal intensities were found in the medulla oblongata and paravermian of cerebellum in MRI and after 11 days, high sisal intensities were reduced in the follow-up MRI. In the ether case, polyneuropathy and right lower brainstem lesion were observed in the NCV and BAEP studies. Conclusion : We confirmed that worker's symptoms were related to methyl bromide exposure in the fumigation. It is necessary that we should evaluate present condition of fumigating process and prepare appropriate methods to prefect workers engaged in the fumigation.

      • KCI등재후보

        음식물 섭취에 따른 요중 마뇨산 배설량의 변화

        김정일,박태혁,정갑열,신해림,김준연 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4

        Objectives : Urinary hippuric acid levels have been usually determined to evaluate workers exposed to toluene. Food and drink intake could affect urinary hippuric acid excretio and this study was carried out to investigate what kinds of food and drink would affect urinary hippuric acid excretion. Methods ; The subjects were 136 medical school students. Authors measured urinary hippuric acid levels three times from 10 a.m. to noon; before, one hour after and two hours after food or drink-intake, and they were asked not to eat from the previous night(9 p.m) of testing. We selected six diets(bread and coffee, brown sauce noodle, Korean style meal, noodle, pork-galbi and rice and soybean stew and rice), six fruits(apple, grape, orange, pear, persimmon and plum) and five beverages(Alps-D(R), Demisoda(R), Orange juice(R), Pear juice(R) and Pocari sweat(R)). Analysis of urinary hippuric acid was performed by high performance liquid chromatography. Results ; Intake of popular Korean diets, fruits and some drinks didn't affect urinary hippuric acid excretion. But intake of sodium benzoate-contained Alps-D(R) increased urinary hippuric acid excretion. Conclusions ; For the health examination on workers exposed to toluene, the history of diet and fruit intake can be negligible, but that of beverage intake should be included.

      • 혈중 및 호기 일산화탄소를 이용한 일산화탄소 헤모글로빈 농도간의 관련성 연구

        김형수,박태혁,손지언,정갑열,김정만,김준연 동아대학교 2001 大學院論文集 Vol.26 No.-

        This study was conducted to find a correlation between blood COHb and calculated COHb with expiratory air and related variables such as occupational and smoking factors. Author selected 69 healthy workers in 8 workplaces suspected CO exposure. Basic informations were collected by self-reported questionnaire and medical history taking. Author measured Indirect COHb concentration with expiratory air using Micro II-Smokerlyzer and blood COHb concentration using Oxymeter. The results of the study were summarized as follows : 1. In the smoker, mean blood COHb and calculated COHb with expiratory air were 2.21±0.98% and 2.27±0.97 %, and there was not a statistically significant difference. In the non-smoker, mean blood COHb and calculated COHb with expiratory air were 0.42±0.43 % and 0,65±0.30 %, and there was also not a statistically significant difference. 2. There were positive correlations between blood COHb and calculated COHb with expiratory air in both the smoker (r=0.91, p=0.0001) and non-smoker (r=0.73, p=0.0001). 3. In the smoker, the factors affected COHb were total smoking index (Pack × years) and passed time after the last smoking. 4. In the nonsmoker, the parking and driving groups had higher COHb concentration than others (p<0.05). In conclusion, there was no significant difference between indirect COHb concentration with expiratory air using Smokerlyzer and blood COHb concentration and there was a highly significant correlation between indirect and blood COHb concentrations. Therefore indirect COHb concentration with expiratory air is a useful screening method for CO exposure. Author suggest the resection of smoking during at least 90 minutes before measuring COHb concentration in order to exclude smoking effects.

      • 음식물 섭취에 따른 요중 마뇨산 배설량의 변화

        김정일,박태혁,정갑열,신해림,김준연 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

        Objectives ; Urinary hippuric acid levels have been usually determined to evaluate workers exposes to toluene. Food and drink intake could affect urinary hippuric acid excretion and chi study was carried out to investigate what kinds of food and drink would affect urinary hippuric acid excretion. Methods ; The subjects were 136 medical school students. Authors measured urinary hippuric acid levels three times from 10 a. m. to noon; before, one hour after and two hours after food or drink-intake, and they were asked not to eat from the previous night(9 p. m) of testing. We selected six diets(bread and coffee, brown sauce noodle, Korean style meal, noodle, pork-galbi and rice and soybean stew and rice) , six fruits(apple, grape, orange, pear, persimmon and plum) and five beverages(Alps-D□, Demisoda□, Orange juice□, Pear juice□ and Pocari sweat□). Analysis of urinary hippuric acid was performed by high performance liquid chromatography. Results ; Intake of popular Korean diets, fruits and some drinks didn't affect urinary hippuric acid excretion. But intake of sodium benzoate-contained Alpa-D□ increased urinary hippuric acid excretion. Conclusions ; For the health examination on workers exposed to toluene, the history of diet and fruit intake can be negligible, but that of beverage intake should be included.

      • 일산화탄소 노출 근로자의 COHb농도의 관련요인에 관한 연구

        김형수,김준연,박태혁,김정일,손지언,정갑열 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

        Two Cases of Neuropathy by Methyl Bromide Intoxication during Fumigation Tae Hyuk Park, Jung Il Kim, Ji Eun Son, Jong Kuk Kim*, Hyung Soo Kim**, Kap Yeol Jung, Joon Youn Kim** Department of Occupational Medicine, Neurology*, Dong-A University Hospital Department of Preventive Medicine and Industrial Medicine Research Institude, College of Medicine, Dong-A University** Objectives : To report two cases of neuropathy due to methyl bromide intoxication. Methods : Welters, engaged in the fumigating process. complained fatigue, general weakness. ataxia. and hypersomnia. We evaluated them with blood testy. neurophysiologic studies and MRI and investigated their occupational history. Results : Increased signal intensities were found in the medulla oblongata and paravermian of cerebellum in MRI and after 11 days, high sisal intensities were reduced in the follow-up MRI. In the ether case, polyneuropathy and right lower brainstem lesion were observed in the NCV and BAEP studies. Conclusion : We confirmed that worker's symptoms were related to methyl bromide exposure in the fumigation. It is necessary that we should evaluate present condition of fumigating process and prepare appropriate methods to prefect workers engaged in the fumigation.

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