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RISS 인기검색어
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- 저자 : 박원대(Won Dae Park) (검색결과 5 건)
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박원대(Won Dae Park),박승국(Soong Kook Park),곽춘식(Choon Sik Kwak) 대한내과학회 1987 대한내과학회지 Vol.32 No.4
N/A This study was carried out to investigate the metabolic alteration of plasma and CSF amino acids in patients with liver cirrhosis only and liver cirrhosis with hepatic encephalopathy. Plasma amino acids were measured in 20 cases of liver cirrhosis only, 17 cases of patients with hepatic encephalopathy and 20 cases of normal person as a control. Among above groups of patients, CSF amino acid concentrations were measured in 15 cases of liver cirrhosis only, 17 cases of patients with hepatic ence-phalopathy and 15 cases of normal person. The plasma amino acid concentrations were determined by high performance liquid chromatography. The results were as follow: The plasma concentrations of branched chain amino acids (valine, leucine, isoleucine) were lower in cirrhotic patients and patients with hepatic encephalopathy (p<0.05) than control group and more decreased in patients with hepatic encephalopathy than cirrhotic patients. The plasma concentrations of phenylalanine in aromatic amino acids increased in hepatic encephalopathy (p<0.05), but tyrosine increased in both group of patients (p<0.05). 1n the study of CSF, there were no significant changes in branched chain amino acid concentrations, but in aromatic amino acid concentrations (phenylalanine, tyrosine) increased (p<0.05). In hepatic encephalopathy compare to liver cirrhosis only, phenylalanine concentration was higher (p<0.05) in CSF. The molar ratio between branched chain amino acids and aromatic amino acids (Val.+Leu.+Isoleu./Phen.+Tyr,) of plasma and CSF were lower in both groups of patients than control. In hepatic encephalopathy com-pare to liver cirrhosis only, the molar ratio was lower in hepatic encephalopthy.
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간경변증환자에서 고농도 분지형 아미노산제제 투여후 혈중 아미노산과 간기능 검사상의 변화 - 일반 아미노산제제와 비교조사 -
안성훈 ( Sung Hoon Ahn ),박승국 ( Soong Kook Park ),박원대 ( Won Dae Park ),한승범 ( Seung Beum Han ),이수형 ( Soo Hyeong Lee ),허정욱 ( Jeug Wook Hur ) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A This study was done to compare the therapeutic effect of enriched branched chain amino acid (BCAA) infusion to regular amino acid infusion for the decompensated liver cirrhosis. Enriched BCAA solution (Pamisol) was given to 30 patients and regular amino acid solution (Salviamine) was given to 8 patints. The changes of plasma amino acid concentrations and liver profiles in before and 7 days after amino acid infusion daily 1,000 ml were compared. The results were as follow. 1) In the group of patients given enriched BCAA infusion, the plasma concentrations of valine, leucine, isoleucine (BCAA) increased (p<0.001), while the phenylalanine, tyrosine (aromatic amino acid: AAA) decreased (p<0.001). 2) In the group of patients given regular amino acid infusion, both BCAA and AAA concentrations increased (p+0.001). 3) In the group of patients given enriched BCAA infusion, total protein increased (p<=0.01), total bilirubin decreased (p<=0.01), prothrombin time shortened (p<0.05), and blood ammonia decreased (p< 0.01). 4) In the group of patients given regular amino acid infusion, only total protein increased (p < 0.01) but, bilirubin, prothromoin time and blood ammonia remained no significant changes. 5) The molar ratio of BCAA/AAA more improved in the enriched BCAA infusion than regular amino acid.
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박승국,전영준,송홍석,윤덕구,박원대 啓明大學校 醫科大學 1985 계명의대학술지 Vol.4 No.2
저자들은 상대정맥증후군을 동반한 Behcet증후군 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Behcet's syndrome consists of the clinical triad of relapsing uveitis, oral andeg nital ulcers. This syndrome is now recognized as a multisystem disease involving mucocutaneous, ocular, intes-tinal, articular, urogenital, vascular and nervous system. Four types of vascular lesions are recognized : arterial occlusion; aneurysms: venous occlusion; and development of varices. Venous lesions are more common than arterial lesions. Venous occlusions are frequently observed, most commonly in the inferior or superior vena cava. Thus, when superior vena caval obstruction is present in a patient, a careful historical review of other lesions associated with Behcet syndrome may prove rewarding. As far as we know, there is no case record of Behcet's syndrome with superior vena cava syndrome in Korea. We report a case of Behcet's syndrome accompanied by superior vena cava syndrome with a review of literature.
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오영철,박승국,전영준,송홍석,박원대,남상숭 대한내과학회 1986 대한내과학회지 Vol.31 No.6
Herein we reported a case of acute copper sulfate intoxication which was the second in our nation. The patient was 23-year old woman, and complained of severe vomiting, upper abdominal pain and jaundice after ingestion of copper sulfate (about 60 gm) for suicidal attempt. The clinical and laboratory findings were consistent with the pictures of intravascular hemolytic anemia. Liver biopsy performed on fifth hospital day showed normal histology in light microscopy. Serial measurements of serum copper and ceruloplasmin concentration during hospital days correlated significantly with clinical course. The symptoms improved all after treatment with the penicillamine and BAL, and the patient discharged oneleventh day of admission.
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간질환 환자에서 α- D- Mannosidase 와 β- D- Mannosidase 의 활성도
곽춘식,안성훈,박승국,황재석,허정욱,박원대 대한소화기학회 1999 대한소화기학회지 Vol.33 No.2
Background/Aims: We studied the activities of α- and β-D-mannosidase to evaluate their diagnostic significance in liver diseases. Methods: One hundred fifty one patients with liver diseases were en rolled. The activities of the enzymes were measured by microquantitative spectrophotometry. Results: The activities of α-D-mannosidase isozymes (neutral and intermediate α-D-mannosidase) were signif icantly high in patients with icteric acute hepatitis (IAH)(48.4 ±25.4, 17.6 ±12.9, 12.2 ±6.2), anicteric acute hepatitis (AAH)(29.9 ±16.0, 11.9 ±5.3, 10.2 ±3.1), cholestatic hepatitis (ChH) (118.3 ±20.6, 50.3 ±12.2, 37.0 ±5.5), icteric liver cirrhosis (ILC)(36.6 ±13.5, 12.0 ±7.8, 9.6 ±4.3), ILC with hepa tocellular carcinoma (HCC)(39.0 ±16.5, 15.1 ±9.4, 11.1 ±5.8). The activity of β-D- mannosidase was also significantly high in patients with IAH (212 ±36), icteric chronic hepatitis (ICH)(193 ±25), ACH (196 ±25), ChH (252 ±38), ILC (188 ±21), ILC with HCC (217 ±55), and ALC with HCC (203 ± 34). Conclusion: The activitiesof α- and β- D-mannosidase were significantly increased in liver diseases with jaundice, which was related to the increased permeability of the liver cell membrane and the leakage of the enzymes into the blood in large quantities. Serial measurement of these enzymes will be helpful to diagnose liver diseases and to understand the clinical conditions of the patients. (Kor J Gastroenterol 1999;33:211 - 221)
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