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Hep G2 세포에서 간염제1탕의 에탄올에 의한 세포독성 억제효과
박용권,김강산,강병기,나기웅,Park, Young-Kweon,Kim, Gang-San,Kang, Byung-Ki,Ra, Ki-Ung 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.1
Object : Hepatitis Treatment-tang No.1 has been used for the treatment of Liver disease and Jaundice. Long-term EtOH exposure leads to immunoregulatory and detoxification impairment. This study aimed to determine the relationship between TNF-${\alpha}$ production and expression, and EtOH-induced cytotoxicity on Hep G2 cells. Method : Cells were incubated with EtOH in the presence or absence of HT. The cells were tested after 24 hours and, again, after 48 hours. Cytoviability and TNF-${\alpha}$ release were analyzed by MTT assay and enzyme linked immunosorbent assay (ELISA), respectively. After 24 hours of EtOH exposure, the cytoviability decreased, and the release of TNF-${\alpha}$ was increased. Increased amounts of TNF-${\alpha}$ contribute to EtOH-induced cytotoxicity. The Anti-TNF-${\alpha}$ antibody almost abolished it. Interestingly, EtOH-induced cytotoxicity and TNF-${\alpha}$ production were inhibited by HT. Moreover, when HT was used in combination with the anti-TNF-${\alpha}$ antibody, there was a marked inhibition of EtOH-induced cytotoxicity. Results : These results suggest that HT may prevent the cytotoxicity through partial inhibition of the TNF-${\alpha}$ secretion.
Ti-6Al-4V 합금의 미세조직 및 기계적 특성에 미치는 Plasma 침탄 처리의 영향
박용권,김택수,지태구,위명용,Park, Yong-Gwon,Kim, Taek-Su,Ji, Tae-Gu,Wey, Myeong-Yong 한국재료학회 2002 한국재료학회지 Vol.12 No.5
In order to improve the low wear resistance of Ti-6Al-4V alloy, plasma carburization treatment was newly carried out without consumption of its good specific strength and fatigue life over the temperature. Effect of the plasma carburization was analyzed and compared with the non-treated alloy by microstructural observation, structure characterization and mechanical property test. The plasma treated alloy formed a carburized layer of about 150$\mu\textrm{m}$ in depth from the surface, where a fine and hard particles of TiC and $V_4C_3$ were homogeneously dispersed through the layer. It was also found that an increase of the wear resistance, fatigue life and hardness, due to the hard and fine dispersoids.
Nb 첨가 Zr 합금의 미세조직과 Creep 특성에 미치는 마지막 열처리 온도의 영향
박용권,윤영권,위명용,김택수,정용환,Park, Yong-Gwon,Yun, Yeong-Gwon,Wi, Myeong-Yong,Kim, Taek-Su,Jeong, Yong-Hwan 한국재료학회 2001 한국재료학회지 Vol.11 No.10
The effects of final annealing temperature on the microstructure and creep characteristics were investigated for the Zr-lNb-0.2X (X=0, Mo, Cu) and Zr-lNb- 1Sn-0.3Fe-0.1X (X=0, Mo, Cu) alloys. The microstructures were observed by using TEM/EDS, and grain size and distributions of precipitates were analyzed using a image analyzer. The creep test was performed at $400^{\circ}C$ under applied stress of 150 MPa for 10 days. The $\beta$-Zr was observed at annealing temperature above $600^{\circ}C$. In the temperature above$ 600^{\circ}C$, the grain sizes of both alloy systems appeared to be increased with increasing the final annealing temperature. The creep strengths of Zr-1Nb-1Sn-0.3Fe-0.1X alloys were higher than those of Zr-1Nb-0.2X ones due to the effect of solid solution hardening by Sn in Zr-lNb-lSn-0.3Fe-0.1X alloy system. Also, Mo addition showed the strong effect of precipitate hardening in both alloy systems. The creep strength rapidly decreased with increasing the annealing temperature up to $600^{\circ}C$. However, a superior creep resistance was obtained in the sample that annealed to have a second phase of $\beta$-Zr. It was considered that the appearance of $\beta$-Zr would play an important role in the strengthening mechanism of creep deformation.
CrN 박막처리된 Ti-6Al-4V 합금의 기계적 성질과 피로특성
박용권,백창현,위명용,Park, Yong-Gwon,Baeg, Chang-Hyung,Wey, Myeong-Yong 한국재료학회 2002 한국재료학회지 Vol.12 No.8
CrN film coated by AIP method, improved the mechanical properties (Hardness, Roughness, wear and fatigue) of Ti-6Al-4V alloy. The properties were studied using GXRD, XPS, Hardness, Roughness, wear and fatigue testers. CrN thin film thickness was about 7.5$\mu\textrm{m}$ and grew with (111) orientation. Hardness of CrN thin film was very high (Hv 1390) and roughness of the surface layer was greatly improved (Ra=0.063$\mu\textrm{m}$) compared with matrix alloy (Ra=0.321$\mu\textrm{m}$). Such changes of hardness and roughness could be contributed to improving the wear resistance and fatigue life. Striation like pattern with dimples and voids, a typical fatigue fracture mode, was observed throughout the specimen.
박용권(Yong Gwon Park),최재하(Jae Ha Choi),위명용(Myeong Yong Wey) 한국열처리공학회 2002 熱處理工學會誌 Vol.15 No.4
N/A The steady-static creep behaviors of Ti-6Al-4V alloy, using the constant stress creep tester, were investigated over the temperature range of 510∼550℃(0.42-0.44Tm) and the stress range of 200-275 MPa(20.41∼28.06 ㎏/㎟). The stress exponents(n) for the static creep deformation of this alloy were 9.85, 9.35, 9.24 and 8.85 at the temperature of 510, 525, 535 and 550℃, respectively. The stress exponent(n) decreased with increasing the temperature and became close to about 5. The apparent activation energies(Q) for the static creep deformation were 254.4, 241.8, 234.4 and 221.9 kJ/mole for the stress of 200, 225, 250 and 275MPa, respectively. The activation energy(Q) decreased with increasing the stress. From the above results, it can be concluded that the static creep deformation for Ti-6Al-4V alloy was controlled by the dislocation climb over the ranges of the experimental conditions. Larson-Miller Parameter(P) for the crept specimens of Ti-6Al-4V alloy under the static creep conditions was obtained as P=(T+460) (log t_T+21). The failure plane observed by SEM showed up dimple phenomenon at all range.