인삼의 황노화효과와 미래의 연구 방향

박영철,이선동,정해원 대한보건협회 1999 대한보건연구 Vol.25 No.2

인간의 평균수명 증가와 함께 노년인구의 증가로 인한 노인층이 차지하는 비율이 증가함에 따라 최근에 노화의 원인과 기전에 대한 연구가 진행되면서 다양한 항노화성 물질이 소개되고 있다. 지금까지 알려진 노화설은 여러가지로 추정되고 있는데 예를 들어 유전자설(genome-based theory), 프리라디칼설(Free radical theory)과 최근의 복제적 세네센스 현상(replicative senescence), 세포노화에 따라 telomere의 길이가 짧아지는 이론 등이다. 이중 인삼의 항노화작용에 대한 연구는 프리라디칼 생성에 대한 세포내 몇가지 방어적 시스템과 관련하여 연구가 이루어졌다. 인삼의 ginsenoside에 의해 SOD를 비롯하여 항산화효소의 발현 및 라디칼에 의한 상해를 수복하는 수복효소 등의 발현에 관여하여 직접적으로 라디칼 제거기능과 특히 Gensenoside의 예방적 항산화제 기능측면내에 SOD발현에 신호전달기전에 대한 규명은 한약제의 항노화적 효능을 과학적으로 입증했다는데 큰 의의가 있다. 특히 세포의 신호전달체계와 관련하여 NO의 역할이 second messenger로서 최근에 활발히 연구되고 있는데 Gensenoside 역시 NO synthase활성을 유도하여 NO 생성, SOD와 Catalase 등의 활성유도를 촉진시키며 또한 세포내 지질과 단백질 등 거대분자에 작용하여 라디칼을 제거하는 항산화기능을 확인하였다. 이러한 점은 인삼의 抗老化機能이 다양한 경로를 통해 이루어지며 인삼의 중요한 항노화기전으로 이해할 수 있다. 그러나 인삼의 항노화성의 우수성을 입증하기 위해서는 앞으로 무엇보다도 한의학적 약효에 대한 좀더 깊은 이해와 과학적인 기전연구와 지속적 접근이 매우 필요할 것이 사료된다. From the turn of this century, human life span has been abruptly increased. In recent decades, interest in various aspects of aging has accelerated in great park owing to the realization that not only do the elderly form an increasing percentage of the population. There are two main theory for aging mechanisms known up to now, for example, genome based theory and free radical theory. Here, the studies on anti-aging function of ginseng have been reviewed in terms of free radical theory. The ginsenoside has the function that remove free radical at first band, concerning expression of anti oxidant enzyme, SOD. Especially, the finding that ginsenoside participates in signal transduction pathway for SOD expression is very important in proving anti aging function of ginseng. Moreover, related to the signal transduction, the NO's role has been recently empathized as second messenger. The ginseng induces expression of NO synthase and generates NO which also activate the induction of SOD. Besides, ginseng's role for anti-aging has been achieved through various ways. However, such studies are too far way from recent trends for aging, especially in the field of free radical theory. Thus, ginsenoside should be applied to recent trends of aging study such as telomere and restriction diet related to free radical generation.

인삼의 황노화효과와 미래의 연구 방향

박영철,이선동,정해원 사단법인 대한보건협회 2005 대한보건연구 Vol.31 No.2

카드뮴만성폭로에 따른 세포내성에 대한 연구 ( a study on the resistance induced by chronic Exposure to cadmium )

박영철,한정호,정해원 한국환경성돌연변이발암원학회 1989 한국환경성돌연변이·발암원학회지 Vol.9 No.2

The effect of ketamine on the separation anxiety and emergence agitation in children undergoing brief ophthalmic surgery under desflurane general anesthesia

정원주,김운영,문만국,민두재,이윤숙,김재환,박영철 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.3

Background: Emergence agitation (EA) frequently occurs after desflurane anesthesia in children. Ketamine, because of its sedative and analgesic properties, might be useful for the management of separation anxiety and EA. We investigated the preventive effect of ketamine on separation anxiety and EA after desflurane anesthesia in children for brief ophthalmic surgery. Methods: Sixty children, ranging in age from 2-8 years old, undergoing brief ophthalmic surgery were randomly allocated to one of the 3 groups: group C received normal saline, group K1.0 received ketamine 1.0 mg/kg intravenously before entering the operating room, or group K0.5 received ketamine 0.5 mg/kg 10 min before the end of the surgery. Before induction, the separation anxiety score was evaluated. Extubation time, post-anesthesia care unit stay time, postoperative nausea and vomiting, emergence agitation, and pain were assessed. Results: The group K1.0 had a lower separation anxiety score compared with groups K0.5 and C. Extubation time in group K0.5 was significantly prolonged compared with groups K1.0 and C. The incidence of EA and the modified Children's Hospital of Eastern Ontario Pain Scale were significantly lower in group K1.0 and group K0.5 compared to group C, but there was no significant difference between groups K1.0 and K0.5. Conclusions: In children undergoing brief ophthalmic surgery with desflurane anesthesia, ketamine 1.0 mg/kg administered before entering the operating room reduced separation anxiety, postoperative pain, and incidence of EA without delay in recovery. Background: Emergence agitation (EA) frequently occurs after desflurane anesthesia in children. Ketamine, because of its sedative and analgesic properties, might be useful for the management of separation anxiety and EA. We investigated the preventive effect of ketamine on separation anxiety and EA after desflurane anesthesia in children for brief ophthalmic surgery. Methods: Sixty children, ranging in age from 2-8 years old, undergoing brief ophthalmic surgery were randomly allocated to one of the 3 groups: group C received normal saline, group K1.0 received ketamine 1.0 mg/kg intravenously before entering the operating room, or group K0.5 received ketamine 0.5 mg/kg 10 min before the end of the surgery. Before induction, the separation anxiety score was evaluated. Extubation time, post-anesthesia care unit stay time, postoperative nausea and vomiting, emergence agitation, and pain were assessed. Results: The group K1.0 had a lower separation anxiety score compared with groups K0.5 and C. Extubation time in group K0.5 was significantly prolonged compared with groups K1.0 and C. The incidence of EA and the modified Children's Hospital of Eastern Ontario Pain Scale were significantly lower in group K1.0 and group K0.5 compared to group C, but there was no significant difference between groups K1.0 and K0.5. Conclusions: In children undergoing brief ophthalmic surgery with desflurane anesthesia, ketamine 1.0 mg/kg administered before entering the operating room reduced separation anxiety, postoperative pain, and incidence of EA without delay in recovery.

韓國産 수리거미科(Gnaphosidae Pocock,1898)의 分類學的 再整理

정부근(Boo-Geun Jung),김주필(Joo-Pil Kim),송란주(Ran-Joo Song),정종우(Jongwoo Jung),박영철(Young Chul Park) 한국거미연구소 2005 한국거미 Vol.21 No.2

Pocock, 1898 에 의해 최초로 기록된 한국산 거미가 수리거미과여서 한국 수리거미과는 거미연구사에서 중요한 의미를 지니고 있다. 하지만, 그 역사적 의미에 비해서 그 분류학적 연구는 미미한 실정이다. 한국에서 수리거미과에 속하는 거미는 종다양도가 높은데, 현재까지 전체 19 속이 밝혀져있다. 이번 연구에서 우리는 종다양도와 한국거미연구사의 측면에서 수리거미과를 재정리하였다. 한국에서는 19 속 44 종이 밝혀져 있는데 이들 모두를 여기서 다루었다. The spiders of the family Gnaphosidae take a very significant position from the historical point of view since the studies on spiders in Korea strated from the family Gnaphosidae Pocock, 1898 in 1907. Despite its historical meaning, however, taxonomic studies on the spiders of the family Gnaphosidae have been poorly conducted to date. In Korea, the spiders of the family Gnaphosidae are rich and diverse, and a total of 19 genera belong to the family. In this study, we reviewed the spiders of the family Gnaphosidae, an important group from the aspect of species diversity and from the historical point of view in the Korean aranchnology. There are 44 species of the 19 genera currently recognized in Korea, and all of them are included in the review. While reviewing the articles including the original descriptions, we found some terminologies not in agreement according to authors of the articles, especially in the terminologies used to describe the body parts of type - speciemen. In addition, a genus has been no its own Korean nomenclature though there is a scientic name of the genus. Paik placed Poecilochroa coreana, a speces called "Solgaeguemi" in Korean, into the genus Kishidaia in 1992. However, the Korean name of the genus has not been generated yet in the family Gnaphosidae. Thus, the Korean nomenclature of the genus Kishidaia has been newly designated as the genus "Kisidaguemi" in this study. From the evolutionary point of view, our review of the family Gnaphosidae, based on the original articles describing the type speciemens, will contribute the construction of the morpholo-anatomical database to understand the phylogenetic relationship among the genera of the family Gnaphosidae.

CHO 세포에서 비소의 세포독성기전 ( Mechanism of Arsenic-Induced Cytotoxicity in CHO Cells )

정해원,기혜성,박영철,한정호,유일재 한국환경성돌연변이발암원학회 1996 한국환경성돌연변이·발암원학회지 Vol.16 No.2

G.723. 1 음성부호화기의 G.729A 음성부호화기의 상호 부호화 알고리듬

윤성완,정성교,박영철,최용수,윤대희 한국통신학회 2001 韓國通信學會論文誌 Vol.26 No.4

유/무선 통신 시스템에서는 통신망보다 서로 다른 음성 부호화기를 사용하므로 음성신호는 두 번의 부/복호화과정을 거치게 되어 음질저하, 연산량 증가, 그리고 전달 지연 증가 등의 문제가 발생된다. 본 논문에서는 위의 문제점들을 개선하기 위하여 유/무선 음성통신에 사용되는 음성 부호화기의 상호 부호화 알고리듬을 제안하고, 5.3 kbps G. 723.1의 패킷과 8 kbit/s G.729.A 패킷을 서로 변환하는 방법을 제안한다. 여러 가지 음성 상호 대해 객관적 음질 평가와 주관적 선호도 평가를 수행한 결과, 제안된 상호 부호화 알고리듬이 이중 부/복호화보다 짧은 전달 지연 시간과 26-37% 적은 연산량으로 동등한 음질의 음성신호를 복호화함을 확인하였다.

GOSPEL SWITCHING FABRICS의 성능분석 ( A Performance Analysis of GOSPEL Switching Fabrics )

장진상,정재수,박영수,류승문,박영철 대한전자공학회 1993 대한전자공학회 학술대회 Vol.1993 No.1

G.723.1 음성부호화기와 EVRC 음성부호화기의 상호 부호화 알고리듬

김경태,정성교,윤성완,박영철,윤대희,최용수,강태익 한국통신학회 2003 韓國通信學會論文誌 Vol.28 No.5C

GOSPEL 스위칭 페브릭의 성능분석 ( A Performance Analysis of GOSPEL Switching Fabrics )

장진상,정재수,박영수,류승문,박영철 한국통신학회 1993 한국통신학회 학술대회논문집 Vol.- No.-