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        N-Terminal Pro-B-Type Natriuretic Peptide in Overweight and Obese Patients With and Without Diabetes: An Analysis Based on Body Mass Index and Left Ventricular Geometry

        박승제,조경임,정선재,최성원,최재원,이동원,이현국,김태익 대한심장학회 2009 Korean Circulation Journal Vol.39 No.12

        Background and Objectives: Several recent studies have shown that there is an inverse relationship between plasma B-type natriuretic peptide (BNP) and body mass index (BMI) in subjects with and without heart failure. Obesity frequently coexists with diabetes, so it is important to consider the relationship between diabetes and natriuretic peptide levels. We evaluated the influence of diabetes on the correlation of BNP and BMI. Subjects and Methods: We examined 933 patients with chest pain and/or dyspnea undergoing cardiac catheterization between Feb. 2006 and Nov. 2007 in the Maryknoll cardiac center who had creatinine levels <2.0 mg/dL and normal systolic heart function. BMI was checked, transthoracic echocardiography was performed, and aminoterminal pro-brain natriuretic peptide (NT-proBNP) was sampled at the start of each case. Results: In 733 nondiabetic patients, mean plasma NT-proBNP levels of non obese individuals (BMI <23 kg/㎡), overweight individuals (23≤ BMI <25 kg/㎡), and obese individuals (BMI ≥25 kg/㎡) showed a significant negative correlation with increasing BMI (856.39±237.3 pg/mL, 601.69±159.6 pg/mL, 289.62±164.9 pg/mL, respectively, p<0.0001). However, in 200 diabetic patients, the correlation between BMI and NT-proBNP was not significant (r=-0.21, p=0.19), and NT-proBNP did not correlate with mitral E/Ea in obese diabetic patients (r=0.14, p=0.56). NTproBNP was significantly correlated with mitral E/Ea in the non-obese (r=0.24, p=0.008) and non diabetic (r=0.32, p=0.003) groups. Left ventricular (LV) mass index was significantly correlated with NT-proBNP in all BMI groups (r=0.61, p<0.001), and patients with concentric cardiac hypertrophy showed the highest NT-proBNP levels. Conclusion: The present study demonstrates that obese patients have reduced concentrations of NTproBNP compared to non obese patients despite having higher LV filling pressures. However, NT-proBNP is not suppressed in obese patients with diabetes. This suggests that factors other than cardiac status affect NT-proBNP concentrations. Background and Objectives: Several recent studies have shown that there is an inverse relationship between plasma B-type natriuretic peptide (BNP) and body mass index (BMI) in subjects with and without heart failure. Obesity frequently coexists with diabetes, so it is important to consider the relationship between diabetes and natriuretic peptide levels. We evaluated the influence of diabetes on the correlation of BNP and BMI. Subjects and Methods: We examined 933 patients with chest pain and/or dyspnea undergoing cardiac catheterization between Feb. 2006 and Nov. 2007 in the Maryknoll cardiac center who had creatinine levels <2.0 mg/dL and normal systolic heart function. BMI was checked, transthoracic echocardiography was performed, and aminoterminal pro-brain natriuretic peptide (NT-proBNP) was sampled at the start of each case. Results: In 733 nondiabetic patients, mean plasma NT-proBNP levels of non obese individuals (BMI <23 kg/㎡), overweight individuals (23≤ BMI <25 kg/㎡), and obese individuals (BMI ≥25 kg/㎡) showed a significant negative correlation with increasing BMI (856.39±237.3 pg/mL, 601.69±159.6 pg/mL, 289.62±164.9 pg/mL, respectively, p<0.0001). However, in 200 diabetic patients, the correlation between BMI and NT-proBNP was not significant (r=-0.21, p=0.19), and NT-proBNP did not correlate with mitral E/Ea in obese diabetic patients (r=0.14, p=0.56). NTproBNP was significantly correlated with mitral E/Ea in the non-obese (r=0.24, p=0.008) and non diabetic (r=0.32, p=0.003) groups. Left ventricular (LV) mass index was significantly correlated with NT-proBNP in all BMI groups (r=0.61, p<0.001), and patients with concentric cardiac hypertrophy showed the highest NT-proBNP levels. Conclusion: The present study demonstrates that obese patients have reduced concentrations of NTproBNP compared to non obese patients despite having higher LV filling pressures. However, NT-proBNP is not suppressed in obese patients with diabetes. This suggests that factors other than cardiac status affect NT-proBNP concentrations.

      • KCI등재

        하지동맥경화증에 있어 3차원적 나선형 전산화 단층촬영 혈관조영술의 유용성

        박승제 대한영상의학회 1997 대한영상의학회지 Vol.36 No.2

        Purpose : To assess the usefulness of three-dimensional spiral CT angiography in the diagnosis and as a guide for the treatment of arteriosclerosis obliterans of the lower extremity. Materials and Methods : During a recent one-year period, CTA and conventional angiography were performed in 12 patients with suspected ASO. From the upper margin of the third lumbar vertebral body to below the knee joint, helical CT scanning was performed 30-45 seconds after the injection of Ultravist 370(150-180ml) by a power injector at the rate of 2.5-3.0ml/sec via the antecubital vein. The resulting data were reformatted by SSD after reconstruction of 5mm intervals, and CTA was compared with CA for site and degree of stenotic or occlusive lesion. Results : On CTA and CA, twenty-three occlusive lesions above the tibioperoneal artery were detected in 12 patients. On CA, three mild seven moderate and eight severe stenoses were seen, as well as five occlusions. There were three cases of overgrading and three of undergrading. Overall diagnostic accuracy was 73.9%(17/23). Calcifications were detected on axial CT scanning in two of three underestimated lesions. Migration of the thrombi was noted in one case. Conclusion : CTA may be useful in the evaluation of the arteries of the lower extremities, and valuable in the planning and follow-up of treatment.

      • KCI등재
      • KCI등재

        열풍과 원적외선 겸용 연속식 백삼 건조기의 개발

        박승제,김성민,김명호,김철수,이종호 한국농업기계학회 2000 바이오시스템공학 Vol.25 No.2

        This study was performed to develop a prototype continuous flow ginseng dryer with which better product quality and lower drying energy consumption could be achieved compared with conventional ginseng dryers. A dryer having both far infrared ray (IR) and heated-air as the drying energy sources was designed and fabricated . Dryer performance was studied by examining energy efficiencies and dryer performance evaluation indices (DPEI) during the drying tests of medium-sized four year ginseng roots with IR radiating plate temperature and drying air temperature in the range of 80-12$0^{\circ}C$ and 22-5$0^{\circ}C$, respectively. The DPEI of IR /heated -air combined drying was 1/3 of that of the conventional heated-air drying when ginseng were dried to the same final moisture ratio. When ginsengs were dried for 12 hours in the prototype IR/heated-air combination dryer, a linear relationship was found to exist between final moisture ratio and ginseng temperature. As the drying progressed, drying air temperature inside the dryer was nearly constant but ginseng temperature was drastically increased during the first two hours and gradually increased thereafter until the end of drying. With the prototype Ir/heated-air combination dryer, the drying rate changed little but the energy efficiency increased proportionally when the amount of ginseng to be dried increased. Drying capacity, energy efficiency, and DPEI of the prototype IR/heated-air combination ginseng dryer were estimated to 1.500 roots, 65% and 3.800kJ/kg-water , respectively.

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