http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
혈액종양의 새로운 치료 ; 최근 개발된 B-세포 림프종의 치료 약제
박병배 ( Byeong Bae Park ) 대한내과학회 2015 대한내과학회지 Vol.88 No.3
While most B-cell lymphomas are cured by chemotherapy, in recent years research interest has focused on the development of monoclonal antibodies and small molecules targeting membrane proteins, components of signaling pathways or tumor microenvironment, which are factors essential for the development and progression of lymphomas. Some of these new drugs have shown substantial clinical activity in phase I and small phase II studies in patients with relapsed and refractory disease, with response rates of up to 50-60% in some cases. These results give hope for patients who have standard treatment failure; however, their incorporation into commonly used regimens also represents a significant challenge for the future. (Korean J Med 2015;88:247-251)
증례 : 혈액종양 ; 급성 백혈병 환자에서 Vincristine에 의해 유발된 다발성 신경병증
백수영 ( Su Young Back ),박병배 ( Byeong Bae Park ),박동원 ( Dong Won Park ),김주형 ( Joo Hyoung Kim ),정경희 ( Kyong Hee Jung ),김혜영 ( Hye Young Kim ),박소연 ( So Yeon Park ) 대한내과학회 2009 대한내과학회지 Vol.76 No.5
본 증례의 경우처럼 급성 림프구성 백혈병 환자에서 항암화학요법 후 발생하는 다발성 뇌신경 및 말초성 신경병증은 유사한 임상증상으로 나타나는 질환들과의 감별진단이 필요하겠고, 중추신경계 증상이 같이 동반되어 있더라도 vincristine에 의한 신경독성의 가능성을 고려해야 하겠다. When neurological symptoms occur during the treatment of acute lymphoblastic leukemia, the differential diagnosis includes a leukemic infiltration of the nervous system, drug toxicity, infection, and other neurological disorders. We describe a 16-year-old girl with acute lymphoblastic leukemia that appeared to be complicated by vincristine-induced peripheral and cranial poly-neuropathy after induction chemotherapy. She presented with right ptosis six weeks after the first dose of vincristine, and her neurological symptoms progressed to peripheral polyneuropathy. She recovered from these neurological symptoms over the next three months. Leukemic involvement of the nervous system and other neurological disorders could be excluded as potential causes of the neurological symptoms. This report shows that vincristine-induced neurotoxicity should be considered as a cause of cranial neuropathy that develops during the treatment of acute lymphoblastic leukemia. (Korean J Med 76:611-616, 2009)
증례 : 혈액종양 ; 중추신경계와 폐를 침범한 말초 T세포 림프종 1예
구태연 ( Tai Yeon Koo ),박병배 ( Byeong Bae Park ),김혜영 ( Hye Young Kim ),김원준 ( Won Jun Kim ),최정혜 ( Jung Hye Choi ),김인순 ( In Soon Kim ),이영렬 ( Young Yeol Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5
말초형 T세포 림프종은 B세포 림프종에 비해 림프절 외 침범이 많고 항암요법에 대한 반응이 낮아서 예후가 불량한 것으로 알려져 있다. 특히 비특정 말초 T세포 림프종은 폐나 신경계의 침범이 매우 드물고 표준 치료가 정립되어 있지 않다. 이 때문에 환자별로 치료자의 판단에 따라 적절한 치료전략이 세워져야 한다. 본 증례는 폐와 신경계를 침범한 비특정 말초 T세포 림프종의 1예로 IMEP 복합항암화학요법과 척추강 내 항암화학요법으로 관해 유도에 성공하였고, 관해 후 치료로써 고용량 항암화학요법 및 자가조혈모세포이식을 시도한 경우이다. Mature T-cell non-Hodgkin`s lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP (ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement. (Korean J Med 77:643-648, 2009)
유한용 ( Han-yong Yoo ),박정래 ( Jung-rae Park ),오태훈 ( Tae-hun Oh ),송보경 ( Bo-kyung Song ),정성훈 ( Seong-hun Jung ),박병배 ( Byeong-bae Park ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
본 시스템은 사용자에게 수질, 수온, 산소량 측정 및 AI 자동 먹이 공급 그리고 불법 어선감지 시스템을 제공한다. 이는 사용자의 사유재산 보호, 효율적인 운영을 통한 경제성 향상 등 양식장 환경 개선을 목적으로 한다.