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RISS 인기검색어
- 검색키워드
- 저자 : 박문승(Mun Seung Park) (검색결과 4 건)
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박문승(Mun Seung Park),박근태(Geun Tae Park),김진배(Jin Bae Kim),황선호(Seon Ho Hwang),윤호주(Ho Joo Yoon),함준수(Joon Soo Hahm),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이민호(Min Ho Lee) 대한내과학회 1997 대한내과학회지 Vol.53 No.1
N/A About a third of the patients with decompensated liver cirrhosis have reduced arterial oxygen saturation and are sometimes cyanosed in the absence of any apparent lung or heart disease; There is a reduction of diffusing capacity without a restrictive ventilatory defect. The aim of this study was to determine diffusing capacities in patients with chronic liver- diseases. The diffusing capacities and arterial oxygen saturations were measured in 25 patients with chronic active hepatitis(CAH), 9 early cirrhotics (early LC), 36 cirrhotics(Child`s class A) and 11 cirrhotics(Child`s class B). The anterior tibial area was observed for pitting edema, and Thallium-201 test per rectum(shunt index) was done. Hypoxemia was not observed in all subjects. The number of cases with decreased pulmonary diffusing capacity (DLco) is 3/25(12.0%) for CAH, 3/9(33.3%) for CAH with early liver cirrhosis(LC), 17/36(47.2%) for LC(Child`s class A) and 6/11(54.5%) for LC(Child`s class B). The mean±standard deviation of Dlco(% predicred) are 93.1±12.1 for CAH, 85.7±12.3 for CAH with early LC, 82.2±14.7 for LC(Child`s class A) and 80.4±6.9 for LC(Child`s class B), There is a significant difference between DLco in CAH and that in LC(Child`s class A)(p<0.01). Patients with higher shunt index(>0.3) had significantly lower DLco than these with lower shunt index(<0.3)(76.4±9.7% vs. 89.3±13.3%)(p<0.01). The DLco was also lower in patients with pitting edema(77.3±10.2%) than in those without pitting edema(85.5±13.8%) (p<0.01). These results summarized that the DLco was low in patients with cirrhosis and with higher shunt index(>0.3) or pitting edema. This may be due to an increased systemic blood flow shunt and an increased generalized interstitial edema. Pulmonary function tests including diffusing capacity may be useful as prognostic parameters in patients with chronic liver disease, especially in those with CAH or early LC.
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간조직 소견이 정상인 HbsAg 건강 보유자에 대한 임상적 연구
황선호(Seon Ho Hwang),박문승(Mun Seung Park),한동수(Dong Soo Han),손주현(Joo Hyun Sohn),윤병철(Byung Chul Yoon),함준수(Joon Soo Hahm),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),이민호(Min Ho Lee) 대한내과학회 1995 대한내과학회지 Vol.49 No.6
N/A Objectives: Thallium-201 test per rectum (Shunt Index) and ICG-Rmax have been used for the evaluation of portosystemic shunt and functional reserve of the liver. The mean values of Shunt Index and ICG-Rmax have not been determined in HBsAg healthy carriers confirmed by liver biopsy. In this stud)', the mean values and correlation between Shunt Index, ICG-I4max and ICG- B15 in these subjects were estimated, and the progression from HHsAg healthy carrier to chronic liver disease was observed prospectively. Methods: Twenty-four HHsAg healthy carriers (male 15 and female 9) were analyzed from 1988 to 1993. The mean duration of follow-up is 17months(range : 2~59). All subjects were diagnosed by liver biopsy. Shunt Index, ICCi-Rmax and ICG-l415 were obtained for each subject 3times weekly. Results: Vive from 24subjects(20.8%) were disclosed chronic persistent hepatitis associated with HHsAg during follow-up period. The mean values of Shunt Index. ICCi-Iimax and ICG-R15 were 0.24±0.07, 4.15±2.21mg/kg/min, and 7.85±3.00% respectively, in seventeen cases whose conventional laboratory data were continuously nor- mal. Shunt Index was well correlated (R-square= 0.34, p<0.0:) with 1.ICG-Rmax. Hut, ICG-Il15 was not correlated with both ICCi-Rmax and Shunt Index. Conclusion: One fifth of the biopsy proven HHsAg healthy carriers progressed to chronic persistent hepatitis associated with HBsAg. We suggest that laboratory follow-up for regular interval is necessary even in HHsAg healthy carriers. The mean values of Shunt Index and ICG-Rmax may be useful in the diagnosis of the chronic liver disease and assessment of outcome of the treatment.
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간동맥 화학색전술 치료를 받은 간세포암 환자의 예후와 혈청 α1 - Antitrypsin 과의 관계
손정일(Chong Il Sohn),황선호(Seon Ho Hwang),박문승(Mun Seung Park),이오영(O . Young Lee),윤병철(Byoeng Chul Yoon),함준수(Joon Soo Hahm),이민호(Min Ho Lee),기춘석(Choon Suhk Kee),박경남(Kyung Nam Park),서흥석(Heung Suk Suh) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
N/A Objectives: Hepatocellular carcinoma(HCC) has a poor prognosis, and only by early detection, cure can be expected by surgery. With development of chemoembolization therapy, we may expect better survival even in the advanced HCC, There many reports about prognostic factors for HCC treated with TAE. We examined relationship between survivals and prognostic factors especially serum a 1-antitrypsin levels in patients with HCC treated with TAE. Methods: 42 patients who had been diagnosed as HCC by ultrasonography and hepatic angiography from 1987 to 1994 were examined for prognostic factors and their survival. Results: Patient's survival who had a single mass was longer (average 21 months) than that of patients who had diffuse tumor(average 4 months, p=0.005). Patient's survival without portal vein thrombosis was longer (average 16 months) than that of patients with portal vein thrombosis (average 4 months, p<0.001). Serologically, patients with low α-fetoprotein level(AFP<40ng/ml) survived longer (average 14 months) than patients with high AFP level(AFP>400ng/ml, average 4 months, p<0.001). Patients with low αl-antitrypsin level (AAT<300 mg/dl) survived longer (average 14 months) than patients with high AAT level (AAT>300mg/dl, average 4 months, p<0.001). Especially, in HCC with low AFP level (AFP<400ng/ml), patients with low AAT level (AAT<300mg/dl) survived longer(average 21 months) than patients with high AAT level (AAT>300mg/dl, average 14 months, p=0.001). Patients with Child's classification A and B showed no signigicant differences in their survival. Conclusion: Serum AAT level may be an important prognostic index in patients with HCC and especially it may be more valuable in patients who had low serum AFP level.
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만성 B 형 간염 환자 간조직의 제 Ⅳ형 Collagen, Laminin, 및 Fibronectin 의 발현과 임상검사 성적과의 비교
이민호,박근태,김진배,황선호,최호순,함준수,기춘석,홍은경,박경남,윤병철,박문승,박문향 대한소화기학회 1999 대한소화기학회지 Vol.33 No.6
Background/Aims: Hepatic fibrosis is caused by increased deposition of liver connective tissue components in the intercellular space. This leads to disturbance of intrahepatic blood flow and hind rance of exchange process between blood and cells. We investigated the deposition of extracellula matrix in the liver of patient with HBsAg positive chronic liver disease and the results were compared with those of other liver function tests. Methods: Needle-biopsied specimen was obtained from 31 patients with mild chronicactive hepatitis (CAH), 30 patients with moderate CAH, 19 pati ents with severe CAH, and 18 patients with cirrhosis. Immunohistochemical stains using antibodies were performed for type Ⅳcollagen, fibronectin and laminin. Results: Shunt index which could be measured with Thallium 201 scan was significantly increased according to the degree of stain for type Ⅳcollagen in portal area, especially in severe chronic active hepatitis and cirrhosis group. Pro thrombin time (%) and serum albumin we decreased according to the degree of stain for laminin in lobule. Conclusions: These results suggest that the deposit of type Ⅳcollagen in portal area i a major contributing factor in the development of intrahepatic shunt and the deposit of laminin within Disse' s space may cause impairment of the hepatic function in cirrhosis.
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