생맥산(生脈散)과 생맥산가미방(生脈散加味方)이 NC/Nga 마우스의 아토피 피부염에 미치는 영향에 대한 비교 연구

문효,황충연,홍석훈,홍철희,김남권,조가원,임규상,Moon, Hyo,Hwang, Chung-Yeon,Hong, Seok-Hoon,Hong, Chul-Hee,Kim, Nam-Kwen,Jo, Ga-Won,Lim, Kyu-Sang 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.1

Objective : This study was carried out to compare Saengmaeksan-gamibang(SG) to Saengmaeksan(SM) on the efficacy of moisturization, skin whitening, anti-inflammation, and anti-allergy in atopic dematitis using NC/Nga mice model. Methods : We assessed the effects of SG and SM on tyrosinase, filaggrin, serine-palmitoyl transferase(SPT), COX-2, AP-1 in vitro, on IgE, IL-4, IL-5, IL-6, IgM, IgG1, IFN-${\gamma}$ in vivo with NC/Nga mice. Results : 1. SG increased the tyrosinase inhibition activity and the levels of filaggrin and SPT, decreasing the level of COX-2. 2. On the other hand, SM decreased the tyrosinase inhibition activity and the levels of filaggrin and SPT, increasing the level of COX-2. 3. Serum IgE, IL-4, 5, 6, IgM, and IgG1 were decreased in both SG group and SM group compared to the control group. The decrease degree in these factors was higher in SG than in SM. 4. Serum IFN-${\gamma}$ was increased in both SG group and SM group compared to the control group. The increase degree in IFN-${\gamma}$ was higher in SG than in SM. Conclusion : As the result of the above experiments, it was proved that SG has the moisturization, skin whitening, anti-inflammation, and anti-allergy effects, which are greater than those of SM, and provides the significant efficacy on atopic dermatitis treatment.

Plant sources, extraction techniques, analytical methods, bioactivity, and bioavailability of sulforaphane: a review

문효,hanxionggao,오건,임지현,임준석,조근희,최선일,이옥환 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.3

Sulforaphane (SFN) is an isothiocyanate commonly found in cruciferous vegetables. It is formed via the enzymatic hydrolysis of glucoraphanin by myrosinase. SFN exerts various biological effects, including anti-cancer, anti-oxidation, anti-obesity, and anti-inflammatory effects, and is widely used in functional foods and clinical medicine. However, the structure of SFN is unstable and easily degradable, and its production is easily affected by temperature, pH, and enzyme activity, which limit its application. Hence, several studies are investigating its physicochemical properties, stability, and biological activity to identify methods to increase its content. This article provides a comprehensive review of the plant sources, extraction and analysis techniques, in vitro and in vivo biological activities, and bioavailability of SFN. This article highlights the importance and provides a reference for the research and application of SFN in the future.

구안와사 환자의 삶의 질에 대한 연구

문효,박민철,홍석훈,윤인환,이동효,이충호,김남권,Moon, Hyo,Park, Min-Cheol,Hong, Seok-Hoon,Youn, In-Hwan,Lee, Dong-Hyo,Lee, Chung-Ho,Kim, Nam-Kwon 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.1

Objective : The face is very important for human communication. So facial palsy patients experience not only physical disturbances but also serious emotional stress. Therefore the focus of treatment must be to not only aid the recovery of objective symptoms but also the improvement of subjective quality of life. However there has not been enough Oriental Medical study in this field until now. Thus this study was begun to suggest a useful index for the treatment of facial palsy. Methods : Grade of paralysis, sequelas, and quality of life were used for evaluation. To evaluate Grade of paralysis, House-Brackman Grade was used as the Gross scale and Kim's Grade was used as the Regional scale. Sequelas were evaluated by muscle contraction, synkinesis, NA, and grade of philtrum tilt. Quality of life was evaluated by SF-36v2, Facial Disability Index, and Vas. Results & Conclusion : 1. The change of grade of paralysis between the early and the present time reveals remarkable improvement statistically. 2. There was a remarkable improvement in all parts of quality of life except several areas of SF-36(RP, RE, MH, VT) 3. In only PF(Physical Function) of FDI, quality of life increased remarkably according to the improvement of grade of paralysis. 4. There is the positive relationship among Kim's grade, HB grade and Synkinesis 2. 5. Synkinesis among sequelas has the greatest effect on quality of life. And muscle contraction, change of NA, and grade of philtrum tilt also affect quality to some extent. 6. There was no remarkable relationship between the period of illness and change of quality of life. 7. Change of NA is shown after 3 months of illness and synkinesis becomes worse after 6 months of illness.

Physicochemical, nutritional and functional properties of Cucurbita moschata

문효,최선일,hanxionggao,권희연,장길웅,최예은,박성민,이옥환 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.2

Cucurbita moschata is widely planted in mostparts of the world, and is rich in carotenoids, vitamins,dietary fiber, minerals, and phenolic compounds. It also hasimportant medicinal value. Some related research hasproven that Cucurbita moschata has the potential ability toinduce anti-obesity, anti-diabetic, antibacterial, and anticancereffects. At the same time, it has attracted moreattention in the medical field. These nutrients and bioactivecompounds in Cucurbita moschata have important effectson human health. In order to make better use of this crop, itstill needs further study. Therefore, the purpose of thisarticle is to summarize the physicochemical properties andnutritional components of Cucurbita moschata, and toprovide a reference for further research on the benefits ofon human health.

紫斑病의 臨床的 觀察

文孝君,車相德,陰斗銀,羅秀燮 金原出版 1969 小兒科 Vol.10 No.3

대학 축구선수들의 자기관리가 운동만족 및 운동지속의지에 미치는 영향

문효인(Hyo-In Mun) 한국발육발달학회 2021 한국발육발달학회지 Vol.29 No.1

The subjects of this study were athletes who participated in the 56th Taebaeksangi Autumn College Football Federation from August 12th to 28th, 2020 as the population. Sampling was performed using the Random Sampling Method, and they were asked to respond to the questionnaire by the Self-Administrated Method and collected on the spot. Through this process, a total of 233 (94.3%) data were used as final analysis data, excluding the data of 17 respondents who did not meet the research purpose due to unscrupulous questionnaire responses among 250 respondents. The data processing is Windows ver. The frequency analysis was conducted using SPSS 21.0 statistical program to verify the validity of the collected data, exploratory factor analysis was conducted using Varimax method among the orthogonal ex-post-school methods, Cronbach"s coefficient was calculated to verify reliability, multiple regression analysis was conducted to verify the effect of self-organization on exercise satisfaction and exercise adherence intention. Correlation analysis was conducted. The statistical significance level was .05. First, the training management factors and the physical management factors of self-management had statistically significant effects on the environmental satisfaction of exercise satisfaction, and the interpersonal management factors of self-management had statistically significant effects on the sports satisfaction of athlete life.,The physical management factor of self-management had a statistically significant effect on the leadership of the leader of the exercise satisfaction factor. Second, the training management factors and the physical management factors of self-management had statistically significant effects on the exercise adherence intention. Third, environmental satisfaction factors of exercise satisfaction and leadership factors of leaders have statistically significant effects on exercise adherence intention. Overall, self-management of college soccer players has a positive effect on exercise satisfaction and exercise adherence intention.

변이를 고려한 PPC 평가절차 및 평가차트 제안

문효기,유정호,김창덕,Moon, Hyo-Gi,Yu, Jung-Ho,Kim, Chang-Duk 한국건설관리학회 2009 한국건설관리학회 논문집 Vol.2 No.3

PPC(Percent Plan Complete)는 계획 작업량 대비 수행 작업량을 의미하며 PPC 측정을 통해 협력업체의 계획 신뢰도를 향상시키며 프로젝트 관리자의 공정계획 능력을 향상시킴으로써 후속 공정의 생산성 향상과 자재 절감 및 시간 버퍼의 단축이 가능하다. 기존 성과지표인 공기, 비용은 실제 문제가 발생하는 작업을 판단하는 데 오류가 발생하나 PPC는 실제 문제가 있는 작업을 말해주므로 측정 결과에 따라 즉각적인 대책수립이 가능하다. 이러한 PPC는 측정과정이 간단하여 현장 적용성이 매우 높다. 때문에 최근 PPC를 측정하여 작업의 성과를 측정하는 사례가 증가하고 그 유용성은 검증되었지만, 작업을 수행한 내력에는 차이가 있음에도 불구하고 기존 PPC 평가는 단순히 추이 분석 또는 평균치와의 비교로 작업을 분석 평가 하고 있다. 따라서 본 연구에서는 측정된 PPC를 중앙경향치 평가뿐만 아니라 변이를 고려하여 PPC를 평가하는 절차 및 평가차트를 제안하고자 한다. PPC stands for the percentage of weekly assignments completed. It makes it possible to improve the performance of production planning and control systems. Recently, the cases of PPC application have been increasing because PPC is easy to apply to construction site. However, to evaluate the average of PPC or analyze PPC as time passes has some problem ; if PPC is the same, the average it is evaluated equally although there are variabilities in production system. Therefore, In order to evaluate the character of PPC in process of production this paper suggests the method of the evaluating PPC by using coefficient of variability besides PPC measurement.

TFV이론에 기초한 작업 성과측정 방법에 관한 연구

문효기(Moon Hyo-Gi),유정호(Yu Jung-Ho),김창덕(Kim Chang-Duk) 대한건축학회 2008 大韓建築學會論文集 : 構造系 Vol.24 No.7

In order to obtain good project performance, the performance of construction work process should be improved. Traditionally, good project performance means a project is on budget and on time with expected quality. Thus, most project managers have used project performance indicators concerning time, cost, quality, safety, profitability, etc. However, these performance indicators focus on a phase of company or project, and it is difficult of these performance indicators to discover potential problems. Thus, this paper suggests three concepts, based on TFV, that are reliability, efficiency and effectiveness to measure the performance of task and we apply them to construction site for usability.

변이를 고려한 PPC 평가절차 및 평가차트 제안

문효기,유정호,김창덕 한국건설관리학회 2009 한국건설관리학회 논문집 Vol.10 No.2

PPC(Percent Plan Complete)는 계획 작업량 대비 수행 작업량을 의미하며 PPC 측정을 통해 협력업체의 계획 신뢰도를 향상시키며 프로젝트 관리자의 공정계획 능력을 향상시킴으로써 후속 공정의 생산성 향상과 자재 절감 및 시간 버퍼 단축이 가능하다. 기존 성과지표인 공기, 비용은 실제 문제가 발생하는 작업을 판단하는 데 오류가 발생하나 PPC는 실제 문제가 있는 작업을 말해주므로 측정 결과에 따라 즉각적인 대책수립이 가능하다. 이러한 PPC는 측정과정이 간단하여 현장 적용성이 매우 높다. 때문에 최근 PPC를 측정하여 작업의 성과를 측정하는 사례가 증가하고 그 유용성은 검증되었지만, 작업을 수행한 내력에는 차이가 있음에도 불구하고 기존 PPC 평가는 단순히 추이 분석 또는 평균치와의 비교로 작업을 분석∙평가하고 있다. 따라서 본 연구에서는 측정된 PPC를 중앙경향치 평가뿐만 아니라 변이를 고려하여 PPC를 평가하는 절차 및 평가차트를 제안하고자 한다.

선천성 골형성부전증의 1예

한희동,구무길,차상덕,문효군 中央醫學社 1974 中央醫學 Vol.27 No.6

This 10 months old female was admitted to Ok Cheon St. Mary's Hospital on Aug., 1974, because of growth failure, multiple bony anomalies of the extremities and blue sclera. She was a product of 3rd baby with spontaneous normal delivery at home. During pregnancy her mother had no history of drug ingestion and exposure of radiation and also family problems were not detected. During admission, ophthalmologic findings showed blue sclera, however, hearing disturbances could not be evaluated and laboratory tests were within normal limits except for anemia. X-ray findings revealed multiple healed fractures with bowing of the left forearm, bowing of the femurs, tibias and fibulas, wormian bone and egg-shell appearance of the skull. The diagnosis was established by above clinical findings and multiple bony fractures on x-ray pictures and then this case was presented with a brief review of the literature.