http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
발사하중 조건을 고려한 수중운동체 비행자세 안정장치의 신뢰성해석
장문호(Moon-Ho Jang),김재기(Jae-ki Kim),문정원(Jung-Won Moon),이석제(Seokje Lee),김인걸(In-Gul Kim) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.10
The stabilizer is used to keep the obturator of underwater vehicle gone into the water after launch from the shipboard and the stable flight attitude. In this paper, we estimate the probability of failure, MPP(Most Probable failure Point) and reliability index using the reliability analysis method for any failure criteria with considering random variables as the loading condition and material property. Also, PSA(Probabilistic Sensitivity Analysis) is conducted for each random variables. Results of this paper would be used for RBDO(Reliability-Based Design Optimization) in the future work.
반응면 기법을 이용한 복합재 평판의 신뢰도 및 민감도해석
이석제(Seokje Lee),장문호(Moon-Ho Jang),김재기(Jae-Ki Kim),문정원(Jung-Won Moon),김인걸(In-Gul Kim) 대한기계학회 2013 大韓機械學會論文集A Vol.37 No.4
섬유강화 복합재료는 무게 절감을 위해 다양한 공학 분야에 널리 사용되고 있다. 각 층의 재료 물성치는 일반적인 금속재료에 비해 더 불확실한 것으로 알려져 있으며 하중 방향에 따라 매우 민감하게 반응한다. 그러므로, 복합재 적층판의 설계에서 불확실성을 고려하는 것은 매우 중요하다. 본 논문에서는 COMSOL과 MATLAB을 이용하여 끝단 변위가 설계 요구조건으로 정의된 경우, 재료 물성치를 확률변수로 하는 복합재 적층판에 대한 신뢰성 해석을 수행하였다. 또한 근사기법의 효율성과 정확성을 확인하고 확률론적 민감도 해석을 수행하였다. 결과적으로 수중 비행체의 비행자세 안정장치에 대한 개선된 설계 방법의 적용가능성을 제시할 수 있었다. Advanced fiber-reinforced laminated composites are widely used in various fields of engineering to reduce weight. The material property of each ply is well known; specifically, it is known that ply is less reliable than metallic materials and very sensitive to the loading direction. Therefore, it is important to consider this uncertainty in the design of laminated composites. In this study, reliability analysis is conducted using COMSOL and MATLAB interactions for a laminated composite plate for the case in which the tip deflection is the design requirement and the material property is a random variable. Furthermore, the efficiency and accuracy of the approximation method is identified, and a probabilistic sensitivity analysis is conducted. As a result, we can prove the applicability of the advanced design method for the stabilizer of an underwater vehicle.
Type 2 DM 환자에서 인슐린 또는 경구혈당강하제등의 치료에 의한 인슐린 내지환와 Dagradation 장애의 회복
박원근(Won Kun Park),고완(Wang Ko),최웅환(Woong Hwan Choi),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jeng),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.4
N/A The internalization of I-insulin in human erythrocytes was studied using an acid extraction technique (pH 5.7, PBS) from 7 patients with type 11 diabetes mellitus (DM) and 14 normal subjects before and after glucose control. Insulin degradation products from 4 patients with type 11 DM and 14 normal subjects in the same period were assayed using HPLC with Sephadex G-50 column and a radioisotope detector. The maximal rates of insulin internalization (Incubation time: 4 hours, at 37°C) which were decreased before glucose control (50.25±6.99%vs 80.23±7.73%), returned toward normal levels after glucose control (89.5±5.45%). The maximal degradation products of insulin (incubation time: 4 hours, at 37°C) which were decreased before glucose control (62.25±10.50vs 87.75±6.66%), returned toward normal levels after glucose control (91.4±7.60%). These results suggest that in type 11 DM, the decreased rate of insulin internalization and degradation may be one of the contributory factors in the pathogenesis of postbinding resistance, which is reversible with insulin or sulfonylurea treatment.
PCR 을 이용한 인슐린 수용체 β - 소단위의 DNA 측정에 관한 연구
최웅환(Woong Hwan Choi),유계수(Ge Soo Yoo),고근아(Keun Ah Koh),정형진(Hyung Jin Chung),김해엽(Hae Youp Kim),신현호(Hyun Ho Shin),한인권(In Kwon Han),문인걸(In Gul Moon) 대한내과학회 1991 대한내과학회지 Vol.40 No.6
N/A Insulin resistance is one of the most important mechanisms of type II diabetes, which may result from acquired or genetic abnormalities in the pathway of insulin action. As the develoment of cloning method of human insulin receptor precursor cDNA, it has become possible to investigate the insulin receptor at the genetic level. We used the modified PCR technique method that permitted us to employ small amounts of cellular RNA as the initial template to amplify the region that encodes the intracellar β-subunit of the human insulin receptor and C-terminal region of β-subunit. We think that this PCR method will facilitate a definite determination to what degree insulin resistance can be ascribed to genetic alterations in the structure of the insulin receptor molecule in type II diabetes.
Type 2 DM 환자에서 적혈구를 이용한 인슐린 내재화율과 Degradation Products 에 관한 연구
최웅환(Woong Hwan Choi),박원근(Won Kun Park),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jung),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.34 No.3
N/A We studied insulin internalization and degradation at 37℃ in human erythrocytes from patients with type II DM and normal subjects. The internalization of 125I-Insulin in human erythrocytes was studied by using an acid extraction technique (pH 5.7, PBS) from 54 patients with type II DM and 14 normal subjects. Insulin degradation products was assayed with using Sephadex G-50 column, HPLC with radioisotope detector from 4 patients with type II DM and 14 normal subjects. The maximal rate of insulin internalization (Incubation time: 4hours, at 37℃) was decreased in patients with type II DM [51.40±14.67% (±SD) VS 80.23±7.73 % (±SD). P<0.001]. The maximal degradation products of insulin (Incubation time: 4hours, at 37℃) was decreased in patients with type II DM [62.50±10.50% (±SD) VS 87.75±6.66% (SD). p<0.001]. In conclusion, insulin internalization and degradation in human eryhrocytes from patients with type II DM are significantly reduced. These defect may be related to the cellular insulin resistance present in these patients.
인슐린 농도 변화에 따른 인슐린 내재화 ( Internalization ) 와 Degradation 의 변화
박원근(Won Kun Park),최웅환(Woong Hwan Choi),한인권(In Kwon Han),김선우(Sun Woo Kim),정운원(Woon Won Jung),문인걸(In Gul Moon) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A This study was conducted to investigate the effect of ambient concentration of insulin on insulin internalization and degradation in human erythrocytes. The absolute amount of internalized insulin was quantitated by multiplying the concentration of insulin by the percent specifically bound and internalized (by acid extraction method, PBS, pH 5.7) at the various insulin concentration (1.4, 2.5, 12.4, 112.4 ng/m1). The insulin degradation products (IDP) was assayed by using Sephadex G-50 column, HPLC with radioisotope detector in human erythrocytes which were incubated (37℃) at the various insulin concentration (1.43, 2.76, 14.76, 26.60ng/ml). Insulin internalization (ng/ml) increased in human erythrocytes with increasing concentration of insulin (3hr incubation time, 0.336 at 1.4, 0.275, at 2,5, 3.844 at 12.4, and 24.728ng/ml at 112.4ng/ml, 4hr incubation time, 0. 476, at 1.4, 0.925 at 2.5, 4.712 at 12.4 and 38.216ng/ml at 112.4ng/ml). Insulin degradation products (%) increased (2hr incubation time, 20.9 at 1,43; 38.0 at 2.76 and 38.0% at 14.76ng/ml) but no more than at a level of insulin concentration (2.76ng/ml) in normal human erythrocytes. In diabetic human erythrocytes, insulin degradation products (%) also increased (3br incubation time, 14.1 at 1.43, 19.0 at 2,76, 23.0 at 14.76, and 23.2% at 26.60ng/ml, 4hr incubation time, 39.4 at 1.43, 46.9 at ~2.76, 52. S at 14.76 and 53.0% at 26.60ng/ml) but no more than at a level of insulin concentration (14.76ng/ml), This result indicated that the ambient concentration of insulin may play an important role in the regulation of intracellular processing of insulin.
자궁경부 세포진에서 인유두종바이러스감염과 폐경후 편평세포 비정형성과의 연관성
전이경,문인걸,홍성란,김혜선,최종순,박지영,박종숙,김태진,김희숙,Chun, Yi-Kyeong,Moon, In-Gul,Hong, Sung-Ran,Kim, Hye-Sun,Choi, Jong-Sun,Park, Ji-Young,Park, Jong-Sook,Kim, Tae-Jin,Kim, Hy-Sook 대한세포병리학회 2004 대한세포병리학회지 Vol.15 No.2
Postmenopausal squamous atypia (PSA) is a phenomenon characterized by cellular alterations mimicking condyloma in the uterine cervix of postmenopausal women. It is not associated with human papillomavirus (HPV) infection. The aim of this study is to correlate findings with HPV infection and the cytohistologic findings of PSA. Eighty-three smears from postmenopausal women, initially interpreted as ASCUS and low-grade squamous intraepithelial lesions(LSIL), were reviewed according to the criteria of PSA. Fifty-eight cases were subsequently reclassified as PSA. Forty cases categorized as PSA were available for HPV-DNA detection by a nested polymerase chain reaction. Eight of these 40 cases(20%) showed biopsy-proven LSIL lesions. The HPV-DNA was detected in 42.5%(17/40), compared to 25%(5/20) of control cases. The HPV-DNA detection rate of biopsy-proven LSIL was 62.5%(5/8). It has been concluded that cytologic differential diagnosis of PSA from LSIL is difficult due to because of poor histologic and viral correlation.