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Fabrication of Hydroxyapatite Ceramics to Mimic the Natural Bone Structure
문대희,류수착 한국세라믹학회 2011 한국세라믹학회지 Vol.48 No.5
The objective of our study was to produce an imitation bone material consisting of hydroxyapatite with a compact and spongy structure. This study shows the ideal content of SiO_2 and the sintering temperature to produce imitation bone that has the mechanical properties of natural bone. On the basis of our determination of the ideal conditions, a compact part was produced and its mechanical properties were tested. A compact part made of 0.5 wt% SiO_2 and sintered at 1350℃ showed excellent mechanical properties. The bioactivity of the compact part under this condition was tested, and it was found to be bioactive. The porous part was produced by controlling the powder size, and the dual structure was manufactured by combining the compact and porous parts. A water permeability test confirmed that the dual structure had an interconnected pore structure. Therefore, this dual-body structure is feasible for use in the creation of implants.
Human Peripheral Polymorphonuclear Leukocyte에 대한 Proinflammatory Cytokinessl의 작용
송요한,외귀옥,이인규,소서영,문대희,이인우,김형섭,Song, Yo-Han,Oh, Kwi-Ok,Lee, In-Kyu,So, Seo-Young,Moon, Dae-Hee,Lee, In-Woo,Kim, Hyyng-Seop 대한치주과학회 1995 Journal of Periodontal & Implant Science Vol.25 No.2
Human polymorphonuclear leukocytes(PMN) are the most numerous host cell in periodontal pockets and their presumed role is to form a protective barrier between the bacteria and periodontal tissues. Microbial component LPS activates macrophages to produce $IL-1{\beta}$, $MIP-1{\alpha}$, $-1{\beta}$, $TNF-{\alpha}$ and IL-6, etc. These cytokines have autocrine function to the macrophages, and paracrine function to other cell such as PMN and affect them to produce some biological functions. In the present study, human PMN were tested for the expression of $IL-1{\beta}$ and $MIP-1{\alpha}$ mRNA. Also we performed the receptor binding assay and in vitro assay for the antimicrobial action of HL-60 cell to determine whether HL-60 can replace the peripheral PMN in analyzing the biological functions. PMN were stimulated with $IL-1{\beta}$, TPA, $MIP-1{\alpha}$, LPS, IL-2 and total cytoplasmic RNA were extracted for the northern blot analysis. In order to determine the induction kinetics of $IL-1{\beta}$ or $MIP-1{\alpha}$ mRNA expression, cells were stimulated for 0,1,2,3 hours. We found peak expression of $IL-1{\beta}$ mRNA after 1hr of induction with $IL-1{\beta}$, LPS and after 2hr of induction with TPA. $MIP-l{\alpha}$ also induced but a scarce $IL-l{\beta}$ message from PMN. In contrast to the $IL-l{\beta}$ mRNA expression, $MIP-1{\alpha}$ were not induced from PMN in any culture conditions. Receptors for $MIP-1{\alpha}$ were identified on dibutyryl cyclic AMP(dbcAMP)-treated HL-60 as well as peripheral PMN. dbcAMP treatment significantly enhanced antimicrobial action of undifferentiated HL-60 cell. MIP-1 further increased enhancing effect of dbcAMP. $IL-1{\beta}$, to a lesser extent, also increased dbcAMP-induced enhancing effect of antimicrobial action of HL-60 cell.
Putative proinflammatory cytokine유전자의 발현양상과 수용체 분자의 cloing
오귀옥,송요한,서영석,이동환,문대희,김형섭,Oh, Kwi-Ok,Song, Yo-Han,Seo, Young-Seok,Lee, Dong-Whan,Moon, Dae-Hee,Kim, Hyung-Seop 대한치주과학회 1994 Journal of Periodontal & Implant Science Vol.24 No.3
Cytokines expressed specifically in leukocytes subsets and in activated cells, which are involved in chemotaxis and activation of leukocytes, are recently defined as chemokines. Macrophage inflammatory $protein-1{\alpha}(MIP-1{\alpha})$ and $MIP-1{\beta}$ are members of C-C chemokine subfamily which produces wide immunomodulatory, proinflammatory, and hematopoietic modulatory actions. We have studied their gene expression by using Northern blot analysis in various blood cells such as cytolytic T lymphocyte(CTL), helper T lymphocyte(HTL), macrophage, and B lymphocyte. Resting CTL line CTLL-R8 expressed $MIP-1{\alpha}$ mRNA which was downregulated by ConA stimulation. Both of resting and ConA stimulated HTL line Hut78 and Jurkat did not express $MIP-1{\alpha}$ mRNA. There was detectable $MIP-1{\alpha}$ transcript in HTL hybridoma 2B4.11 which was a little upstimulated by ConA stimulation. B cell line 230, and macrophage cell line RAW264.7 and WR19M.1 showed distinct $MIP-1{\alpha}$ message which were induced after LPS stimulation. Expression pattern of $MIP-1{\beta}$ in all cell lines or cell were almost identical to that of $MIP-1{\alpha}$. Also strategies employed to identify and characterize the biological functions was preceded by receptor cloning to trace the shorcut to the final goal of cytokine research. For the cloning of $MIP-1{\alpha}$ receptor(R), we used synthetic oligonucleotides of transmembrane(T) conserved sequences of already cloned human(h) IL-8-R, and performed reverse transcription-polymerase chain reaction(RT-PCR) amplification using murine(m) macrophage cell line mRNA. Among 5RT-PCR products, we isolated a homologous cDNA with hIL-8-R which were shown to be putative mIL-8-R cDNA.
김용민 ( Yong-min Kim ),남지성 ( Ji-seong Nam ),문대희 ( Dae-hee Moon ),최원태 ( Won-tae Choi ),김웅섭 ( Woongsup Kim ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
최근 맞벌이 가정이 많아지면서 베이비 시터를 고용해 영아를 양육하는 경우가 많아지고 있는 추세이다. 본 논문에서는 영유아 상태분석에 따른 인공지능 베이비시터 시스템에 대하여 기술하였다. 보다 상세하게는 얼굴인식을 위한 Opencv 영상처리 기법, MS(azure)API 를 이용한 머신러닝 기반의 감정분석과 악취 센서(MQ-135 Sensor)를 이용하여 영유아의 상태를 파악한다. 파악한 영유아의 상태를 바탕으로 스스로 학습하여 요람을 제어하고 어플리케이션을 통해 원격제어를 할 수 있도록 제작한 스마트 베이비시터 시스템에 관한 것이다. 이에 따라 양육에 대한 부담감이 줄어들 것으로 기대하고 양육에 대한 부담감을 조금이나마 경감 시켜 주어 저출산과 양육 지출 비용 절약으로 사회적 측면, 경제적 측면 모두에 기여할 것을 기대한다.