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태음조위탕(太陰調胃湯) 추출액이 ICR mouse에서의 경구 투여 급성독성에 미치는 영향
마진열,황대선,서창섭,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Seo, Chang-Seob,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2010 사상체질의학회지 Vol.22 No.2
1. Objectives: The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods: We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Taeeumjowi-tang was over 5000 mg/kg and it is very safe to mice.
양격산화탕(凉膈散火湯) 추출액이 ICR mouse에서의경구 투여 급성독성에 미치는 영향
마진열,황대선,서창섭,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Seo, Chang-Seob,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2009 사상체질의학회지 Vol.21 No.3
1. Objectives: The aim of this study is data analysis for acute toxicity and safety of Yangkyuksanhwa-tang. 2. Methods: We investigated the acute toxicity for water-extracted Yangkyuksanhwa-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yangkyuksanhwa-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Yangkyuksanhwa-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yangkyuksanhwa-tang was over 5000 mg/kg and it is very safe to mice.
Mouse(ICR)에 있어서 시험물질 열다한소탕(熱多寒少湯) 추출액의 급성독성 시험
마진열,황대선,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2009 사상체질의학회지 Vol.21 No.1
1. Objectives This study was designed to andyze the acute toxicity and safety of Yeoldahanso-tang 2. Methods We investigated the acute toxicity for water-extracted Yeoldahanso-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yeoldahanso-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions The data confirmed that Yeoldahanso-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yeoldahanso-tang was over 5000 mg/kg and it is very safe to mice.
Mouse에 있어서 시험물질 청심연자탕(淸心蓮子湯) 추출액의 급성독성 시험
마진열,황대선,서창섭,이시우,김종열,신현규,Ma, Jin-Yeul,Huang, Dae-Sun,Seo, Chang-Seob,Lee, Si-Woo,Kim, Jong-Yeol,Shin, Hyeun-Kyoo 사상체질의학회 2010 사상체질의학회지 Vol.22 No.1
1. Objectives: The aim of this study is data analysis for acute toxicity and safety of Cheongsimyeonja-tang. 2. Methods: We investigated the acute toxicity for water-extracted Cheongsimyeonja-tang. Fifty five male and female mice were observed for 14 days after one day oral administration of Cheongsimyeonja-tang at the respective doses of 0 (control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. In animals administered with Cheongsimyeonja-tang, there were nither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical sign and autopsy. 4. Conclusion: The data confirmed that Cheongsimyeonja-tang is free from the toxicity and safety problems in treated groups. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). Lethal Dose 50 (LD50) value for mice was more than 5000 mg/kg per oral for both male and females. It suggest that Cheongsimyeonja-tang in mice is considered to be safe.
고병섭,주혜정,마진열,박갑주,안상우,Go, Byeong-Seop,Ju, Hye-Jeong,Ma, Jin-Yeol,Park, Gap-Ju,An, Sang-U 대한약침학회 1997 Journal of pharmacopuncture Vol.1 No.1
In order to study the reproducibility and effeciency of the manu-pacture system Hwanggum(黃芩) aqua-acupuncuture was prepared. The filtra-tion and dilution have been mainly employed in the study of the manupacture step. These methods were showed possibility of standardization and variety for aqua-acupuncture.
고병섭,박갑주,안상우,주혜정,마진열,전원경,Go, Byeong-Seop,Park, Gap-Ju,An, Sang-U,Ju, Hye-Jeong,Ma, Jin-Yeol,Jeon, Won-Gyeong 대한약침학회 1997 Journal of pharmacopuncture Vol.1 No.1
In order to study of safety, Hwanggum(黃芩) aqua-acupuncture was prepared by boiling extract and filtration. This study was performed to determine the toxic effects of graded dose levels and effects of Scutellaria Root after repeated administration(14days). From these results, Hwanggum(黃芩) aqua-acupuncture was quite sag in male and female rats.
Tetravalent Bispecific 항체 분자인 Di-diabody의 제조 및 표적 단백질에 대한 항염증 영향
정선기(Sun Ki Jung),류창선(Chang Seon Ryu),김선규(Sun Kyu Kim),마진열(Jin Yeol Ma),김상겸(Sang Kyum Kim) 大韓藥學會 2010 약학회지 Vol.54 No.6
TNF-α and VCAM-1 play a pivotal role in the pathogenesis of rheumatoid arthritis, and the development of drugs targeting these molecules has extended the therapeutical approaches to rheumatoid arthritis patients. Bispecific antibodies combine the antigen-binding sites of two antibodies within a single molecule and thus they are able to bind to two different epitopes simultaneously. A specific bispecific antibody format termed “Di-diabody” was made for the efficient approach to anti-inflammation. In this study, the DNA vector construct of Di-diabody was built up against two antigens, VCAM-1 and TNF-α. For evaluating this Di-diabody as a bispecific antibody on the efficacy of anti-inflammation, the proteins were analyzed according to each antigen binding affinity and cell based assay related separate molecules. The 7H/Humira Di-diabody produced in this study interacted with its ligands, VCAM-1 and TNF-α, respectively. Also, this antibody exhibited the similar functional activities as compared to 7H-IgG in respect to inhibition of hVCAM-1-induced cell adhesion and Humira-IgG in respect to inhibition of TNF-α induced cytotoxicity. Further study to elucidate the pharmacological significance of the Di-diabody is warranted using experimental animals.