http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Succinylcholine 이 Atracurium 의 작용시간에 미치는 영향
임웅모,윤명하,류경연,박수택 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.7
For the assessment the effect of succinylcholine (SCh) on atracurium, 59 adult patients undergoing elective surgery under general anesthesia were subjected to this study in which the nEMG response (twitch height) of the hand to TOF stimulation (0.2 Hz) of ulnar nerve was monitored and recorded with Datex Relaxograph. According to the amount and mode of the drugs administered, the patients were divided into four experimental groups; 1) Group I, a bolus injection of atracurium in dose of 0.5 mg/kg 2) Group II, atracurium 1.0 mg/kg, a double dose of group I 3) Group III, atracurium 0.5 mg/kg after 25 to 50% recovery of initial twitch height from twitch height depression induced by SCh (1 mg/kg) 4) Group IV, mixed injection of SCh (1 mg/kg) and atracurium (0.5 mg/kg) Followings were the results. 1. Mean onset time of the atracurium, which was 4.5±0.6 minutes in group I and 4.00.7 minutes in group II, changed to 2.7±0.6 and 4.0+0.8 minutes in group III and IV respectively, showing no significance. 2. Mean action ration of atracurium was 49.1±3.4 minutes in group I and 72.0±3.7 minutes in group II, the latter being significant (p$lt;0.001). It was, however, 49.0±3.6 minutes in group III, indicating that SCh shnwed a little effect, while it was 38.1±1.8 minutes in group IV, being significantly shorter than those of group I and IlI (p$lt;0.01). 3. Mean potency of atracurium expressed by the percentage change of initial twich height was 0.7±0.5% in group I and it was decreased to 0% in group II but it was not sinificant. In group III, it was increased to 0.9±0.6% but it was also no significance. In group IV, it was decreased to 0.4±0.2% which was not significant. 4. Presence of atracurium (0.5 mg/kg) in group IV did not have any effect on the intensity of fasciculation induced by SCh. These results indicate that succinylcholine did not attect the onset time and action potency of atracurium. However, in group of the mixed injection, SCh shortened only the duration of action of atracurium.
개에서 Halothane 마취가 심근허혈-재순환시 관상순환계의 Endothelin-1 생성에 미치는 영향
박찬진,윤명하,김별아,류경연 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.7
Endothelin (ET), a vascular endothelium derived contracting factor, provokes a strong and long lasting contraction of blood vessels, including coronary artery. Chemical stirnuli such as Ca^(++) ionophore (in vitro) and myocardial ischemia (in vivo) are known to promote the production of ET. Since halothane has recently been shown to block Ca^(++) channel, it might blunt ET-1 release or production from ischemic myocardium. To test this hypothesis, open-chest dogs underwent eitber 15 minutes (n=7) of the left anterior descending coronary artery (LAD) occlusion or 30 minutes (n=7) and 120 minutes of reperfusion under the halothane anesthesia. Plasma concentration of ET-1 in the femoral artery (FA) and the great cardiac vein (CV) draining ischemic myocardium was measured using radioimmunoas-say. ET-1 production (pg/mL) was calculated by substrating the ET-1 levels in FA from those in CV. The results were as follows; 1) Baseline ET-1 levels in FA and CV were similar in both groups. 2) ET-1 levels in FA and CV remained unchanged during myocardial ischemia in both groups. 3) ET-1 production significantly increased from baseline at 30, 60 and 120 min into reperfusion, respectively, in the 30 min group, whereas no significant changes were observed from baseline in the 15 min group. These findings indicate that halothane may blunt, but could not block the production or release of ET-1 completely during myocardial ischemia-reperfusion, especially in the case of prolonged coronary arterial occlusion.