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악성 종양 , 만성 염증성 질환 , 및 철 결핍성빈혈 환자에서의 혈중 Erythropoietin 및 Tumor Necrosis Factor α
원종호(Jong Ho Won),라동집(Dong Jip Ra),홍대식(Dae Sik Hong),박희숙(Hee Sook Park) 대한내과학회 1993 대한내과학회지 Vol.45 No.5
N/A Objectives: The aim of this study was to determine the serum erythropoietin (S-EPO) level in anemia of chronic disorders (ACD) and the influence of tumor necrosis factor α (S-TNFα) to S-EPO. We also investigated the relationship between S-EPO and S-TNFα levels and other factors, such as fever and consumptive syndrome. Methods: Serum erythropoietin (S-EPO) and tumor necrosis factor alpha (S-TNFα) levels were measured by radioimmunoassay in 35 patients with anemia, classified into three groups according ta their etiology: neoplastic (n=17), chronic inflammatory (n=9), iron deficiency (n=9), and 10 normal controls. Resultr: The iron deficiency anemia group showed a higher mean S-EPO level (mean value±SEM, 229,05±50.50mU/ml) than the neoplastic (25.09±3.85 mU/ml; p<0.0001), chronic inflammatory (24.38±4.98 mU/ml; p<0.0001), and normal control groups (11.96±0.99 mU/ml; p<0.0001). The neoplastic group showed a higher mean S-TNFα level (6.22±0.33 fmol/ml) than the iron deficiency (3.26±0.18 fmol/ml; p<0.0001) and normal control groups (4.06±0.12 fmol/ml; p<0.0001). The chronic inflammatory disorder group showed a higher mean S-TNFα level (5.39α0.52 fmol/ml) than the iron deficiency anemia group (p<0.0001). There were no significant differences of S-EPO and S - TNFα Level of ACD group in febrile subjects (9 patients with fever and 17 patients without fever) and in weight loss (10 patients with weight loss and 16 patients without weight loss). Conclusion: These data suggested that the cause of ACD is thought to be the inappropriate erythropoiesis and TNFα may preferentially inhibits erythropoiesis.
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김진홍,이문성,조성원,심찬섭,라동집 대한소화기내시경학회 1990 Clinical Endoscopy Vol.10 No.1
A clinical review was performed in 52 cases with the foreign body in the gastrointestinal tract who underwent the endoscopic extraction of fereign body at our hospital from June 1985 to October 1989. The results are as following. 1) The most prevalent age was under 10 years of age (21 cases, 40.4%), and male was more prevalent than female (M:F=1.6:1). 2) The most common site of foreign bodies was esophagus (35 cases, 67.3%), next stomach (15 cases, 28.9%). 3) The foreign bodies in esophagus were coins (18 cases, 51.4%), meats (7 cases, 20.0%), bones (5 cases, 14.3%), other food materials or metals (5 cases, 14.3%)in order of frequency, and those in the stomach wer bezoars (7 cases, 50.0%), coins (2 cases, 14.3%), suture materials (2 cases, 14.3%), others (baduk stone, pin, tack, cross). 4) The combined diseases with upper gastrointestinal foreign bodies were the passage disturbances (11 cases, 21.2%) due to stenosis, and schizophrenia (1 case), aleoholism (1 case). 5) Complications by foreign bodies were 8 cases (15.4%), such as eisophageal laceration or ulceration (4 cases), esophaigeal perforation (1 case), aspiration pneumonia(1 case), duodenal obstruction (2 cases). 6) Successful rate of the endoscopic extraction was 88.5%(46 in 52 cases). And 6 unsuccessful cases were 4 cases who have gastric bezoars too hard and large to extract, a case with esophageal perforation, and a case with bezoar in the third portion of duodenum.
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