골반골에 발생한 방사선속발 골육종 1 예

도영록(Young Rok Do),이춘식,이정은(Jung Un Lee),이원식(Won Sik Lee),송홍석(Hong Suk Song),남성진(Sung Jin Nam) 대한내과학회 1998 대한내과학회지 Vol.54 No.1

Most osteosarcomas arise spontaneously, but rarely they may be secondary to other benign osseous conditions and may occur following irradiation. Postradiation sarcoma of bone is approximately 5.5 percent of all osteogenic sarcoma. Diagnosis is possible when a sarcoma arising after long latent period(more than 3 years) in irradiated bone and the bone is normal or benign osseous lesion at the time of irradiation. The spontaneously arising osteogenic sarcomas are distribute mainly in the knee region, but postradiation sarcoma arise in any bones, such as long bone of the extremity, pelvic bone, vertebra, craniofacial bone and shoulder girdle bone. Recently we experienced a case of postradiation osteosarcoma of the pelvic bone who recieved radiation therapy for carcinoma of the uterine cervix 20 years ago.

원발성 흉선 MALT 림프종 1예

박우영 ( Woo Young Park ),성희진 ( Hee Jin Seong ),이상민 ( Sang Min Lee ),김주연 ( Ju Youn Kim ),김진영 ( Jin Young Kim ),도영록 ( Young Rok Do ),송홍석 ( Hong Suk Song ) 대한내과학회 2008 대한내과학회지 Vol.75 No.3

저자들은 특별한 증상 없이 흉부전산화단층촬영에서 발견된 종격동내 흉선 종양으로 내원하여 수술적 제거 후 추적 검사상 발견된 잔존 종양에 대해 국소 방사선 치료를 시행한 후 현재까지 15개월간 무병 생존을 보인 원발성 흉선 MALT 림프종 1예를 경험 하였기에 문헌고찰과 함께 보고하는 바이다. Primary thymic MALT lymphoma is a rare thymic tumor, with only eight previous cases having been described worldwide to date. We report a case of a 60-year-old Korean woman diagnosed as primary thymic MALT lymphoma. She was found to have an anterior mediastinal tumor during a medical check-up in 2006 and was referred to our hospital for further examination and treatment. The thymus was resected through a median sternotomy and pathology revealed primary thymic MALT lymphoma. Two months later, a follow-up chest CT showed a residual mediastinal soft tissue mass and increased FDG uptake was detected on PET CT scan. The patient was irradiated with 4,140 cGy. After radiation therapy, no evidence of residual soft tissue was found in follow-up chest CT scan and the patient is alive and well 15 months after treatment. We report the details of this case of primary thymic MALT lymphoma treated with irradiation and also offer a review of the literature. (Korean J Med 75:343-348, 2008)

증례 : 항암화학요법으로 장기 생존을 보인 원발성 난소 소세포암 1예

김진영 ( Jin Young Kim ),김용진 ( Yong Jin Kim ),성희진 ( Hee Jin Seong ),박우영 ( Woo Young Park ),홍윤석 ( Yoon Seok Hong ),도영록 ( Young Rok Do ),송홍석 ( Hong Suk Song ) 대한내과학회 2007 대한내과학회지 Vol.72 No.5

저자들은 65세 여자 환자가 직장 중압감을 주소로 내원하여 복부 단층 촬영상에서 난소에 종괴가 확인되어 시행한 조직 검사상 소세포암으로 판명되었으며, 4차례의 cisplatin+etoposide 복합항암화학 요법 시행 후 완전 관해된 뒤 약 5년간 재발의 증거가 없는 경과가 매우 양호한 진행 병기의 원발성 난소 소세포암 1예를 경험하였기에 이에 문헌고찰과 함께 보고하는 바이다. Ovarian small cell carcinoma is a rare type of ovarian carcinoma with a poor prognosis.The hypercalcemic type is a tumor of unknown histogenesis, and small cell carcinoma of the pulmonary type may be a component of a typical ovarian surface epithelial-stromal tumor. We experienced a case of primary ovarian small cell carcinoma and lung metastasis. The patient was a 65-year old woman who complained of rectal heaviness. The chest x-ray and chest CT scan revealed multiple pulmonary metastases. Abdominal MRI showed a well defined heterogenous solid mass with central necrosis arising from the right ovary and hydronephrosis of the right kidney. Biopsy of the ovarian mass showed small cell carcinoma of the pulmonary type. After 4 cycles of cisplatin (80 mg/m2, on day 1, iv), etoposide (100 mg/m2, on day 1 to 3, iv), the patient achieved a complete response. The follow up chest CT scan 5 years after treatment revealed no evidence of disease. We report here in a case of primary small cell carcinoma of the ovary with lung metastasis and we include a review of the literature. (Korean J Med 72:563-567, 2007)

증례 : 항암 화학 요법 및 방사선 요법으로 장기 생존을 보인 상악동에 생긴 골육종 1예

김용진 ( Yong Jin Kim ),김진영 ( Jin Young Kim ),성희진 ( Hee Jin Seong ),박우영 ( Woo Young Park ),권선영 ( Sun Young Kwon ),도영록 ( Young Rok Do ),송홍석 ( Hong Suk Song ) 대한내과학회 2007 대한내과학회지 Vol.72 No.4

저자들은 광범위 수술적 절제가 불가능한 상악동 부위에 생긴 골육종 환자에 대해 항암화학요법과 방사선 요법을 시행하여 장기 생존을 보인 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Maxillary osteosarcoma is an aggressive disease with a high mortality rate. Extensive surgical resection is accepted as the standard treatment for the disease. The beneficial role of chemotherapy and radiotherapy in the treatment of the disorders is uncertain. We experienced a case of an osteosarcoma of the maxillary sinus. Paranasal sinus computed tomography showed a huge solid mass lesion at the left maxillary sinus walls. An endoscopic biopsy showed an osteoblastic type osteosarcoma. In this case, radical surgery was impossible, and the patient was treated with chemotherapy and radiotherapy. This regimen involved four cycles of chemotherapy, cisplatin, 100 mg/m2 intravenously on the first day of weeks 1, 4, 7, and 10, and doxorubicin, 25 mg/m2 per day on the first 3 days of weeks 1, 4. 7. and 10, followed by external beam radiotherapy with a total dose of 6,600 cGy. We report here a case of an inoperable osteosarcoma of the maxilla with long-term survival after chemotherapy and radiotherapy with an accompanying review of the literature. (Korean J Med 72:437-440, 2007)

Metachronous Double Primary Cancer after Diagnosis of Gastric Cancer

김진영,Won Young Jang,Mi Hwa Heo,Kang Kuk Lee,도영록,박건욱,송홍석,김윤년 대한암학회 2012 Cancer Research and Treatment Vol.44 No.3

Purpose The pattern of double primary cancers after treatment for gastric cancer is important for a patient's survival. Materials and Methods We analyzed the clinicopathologic data of 214 gastric cancer patients from October 1996 to November 2007 with regard to metachronous second primary cancers. Results Out of 5,778 patients with gastric cancer, metachronous second primary cancers occurred in 214patients. The median age was 61.8 years, the number of male and female patients was 140 (65.4%),74 (34.6%), respectively. The median time to the occurrence of second cancers after diagnosis of the first was 39.2 months (standard deviation, 31.2 months). The most common cancer was colorectal cancer, which occurred in 44 patients (20.6%), and lung cancer in 33 patients (15.4%),hepatocellular carcinoma in 26 patients (12.1%), ovarian cancer in 15 patients (7.0%), cervical cancer in 12 patients (7.0%), breast cancer in 11 patients (5.1%), and esophageal cancer in 11patients (5.1%). The observed/expected (O/E) ratio showed a significant increase in colorectal (1.25), male biliary (1.60), ovarian (8.72), and cervical cancer (3.33) with primary gastric cancer. After five years from diagnosis of gastric cancer, secondary cancer occurred in 50 patients (23.4%), and breast cancer, prostate cancer, laryngeal cancer, lung cancer, and hepatocellular carcinoma were the most frequent. Conclusion The O/E ratio showed a significant increase in colorectal, male biliary, ovarian, and cervical cancer with primary gastric cancer, and second primary cancer as the main cause of death for these patients. A follow-up examination for metachronous double primary cancer is needed in order to improve the survival time in patients with gastric cancer.

Ultracet(R)을 이용한 통증 조절이 암 환자의 삶의 질(QOL)에 미치는 영향

송홍석 ( Hong Suk Song ),도영록 ( Young Rok Do ),박건욱 ( Keon Uk Park ),손인기 ( In Ki Sohn ) 대한내과학회 2005 대한내과학회지 Vol.68 No.5

목적 : 암성 통증의 관리에 있어 Ultracet(R)의 효율성과 부작용을 살펴보고, Ultracet(R)의 치료로 인한 삶의 질에 대한 변화를 알아보고자 실시하였다. 방법 : 2003년 2월부터 2004년 1월까지 계명대학교 동산의료원 혈액종양내과에서 통증 조절을 목적으로 한 97명의 환자를 대상으로 통증 조절의 정도와 삶의 질에 대한 변화를 알기위해 brief pain inventory, WHO QOL-BREF와 EORTC QLQ-C30을 이용한 설 Background : Cancer pain impacts the patient and improved pain management increases the quality of life (QOL) for the patient and entire family. One tablet of Ultracet(R) is composed of 37.5 mg of tramadol hydrochloride and 325 mg acetaminophen. Mechanism

Optimization of Protoplast Culture Procedure for CRISPR-Cas9 based Mutation in Cucumis melo L.

Ju-seon Kim(김주선),Young-Rok Do(도영록),Beum-Chang Kang(강범창),Mingu Kang(강민구),Youngjin Seo(서영진),Jeung-Sul Han(한증술) 한국원예학회 2023 한국원예학회 학술발표요지 Vol.2023 No.10

난원공개존과 동반된 양측성후뇌동맥경색

박정아(Jung A Park),도영록(Young Rok Do),이동국(Dong Kuck Lee) 대한임상노인의학회 2017 대한임상노인의학회지 Vol.18 No.2

Posterior cerebral artery (PCA) infarction is a common and important cause of acute painless visual loss. To our knowledge, nearly total blindness due to bilateral PCA infarction is rare. Patent foramen ovale (PFO) is one of the crucial causes of cryptogenic stroke and it should be regarded as a cause of stroke when cerebrovascular stenosis or other cardioembolic causes of stroke is absent. We report a case of bilateral PCA infarction due to PFO presenting as nearly total blindness.

근치적 절제술을 시행한 위암환자에서 예후인자로서 연령의 의의

송홍석 ( Hong Suk Song ),도영록 ( Young Rok Do ),류승완 ( Seung Wan Ryu ),김인호 ( In Ho Kim ),손수상 ( Soo Sang Sohn ) 대한내과학회 2005 대한내과학회지 Vol.68 No.3

수술이 불가능한 식도암에서 동시 항암화학방사선요법의 효과

김용진 ( Yong Jin Kim ),김진영 ( Jin Young Kim ),도영록 ( Young Rok Do ),송홍석 ( Hong Suk Song ),김옥배 ( Ok Bae Kim ) 대한내과학회 2007 대한내과학회지 Vol.72 No.1

목적: 본 연구는 cisplatin과 5-fluorouacil을 사용한 동시 항암화학방사선 요법을 통해 수술이 불가능한 식도암에서 안전성과 효과를 평가하였다. 방법: 2001년 4월부터 2004년 12월까지의 원격 전이가 없는 식도암 환자 28명을 대상으로 cisplatin과 5-fluorouacil을 사용한 동시 항암화학방사선 요법을 시행한 군에 대해 후향적 평가를 하였다. 결과: 대상에 포함된 28명 중 자발적 치료 중단으로 2명, 백혈구 감소로 1명이 계획된 방사선 선량을 조사하지 못하였다. 총 28명의 치료반응은 완전 관해가 15명(54%), 부분적 관해가 10명(36%)으로 치료 반응률은 89%였다. 총 28명의 1년, 3년 생존율은 각각 66%, 30%였고, 1년, 3년 무진행 생존율은 각각 78%, 48%이었다. 중간 생존 기간은 13.1개월이었다. 본 치료의 독성 중에서 grade3 및 4 혈액학적 독성은 백혈구 감소가 50%, 중성구 감소가 40%, 혈소판 감소가 14%, 혈색소 감소는 25%, 발열성 백혈구감소는 14%였고, 3명(11%)이 감염으로 인하여 사망하였다. 비 혈액학적 독성 중 grade 3 이상의 비혈액학적 독성은 드물었다. 결론: 원격 전이가 없는 식도암 환자에서 동시 항암화학방사선요법은 매우 유효한 치료로 생각되며, 혈액학적 부작용으로 인한 치료 관련 사망률이 다소 높아 앞으로 이에 대한 추가적인 연구가 필요하다고 생각된다. Background: Carcinoma of the esophagus traditionally has been treated with surgery or radiation therapy. The aim of this study was to assess the effect and safety of chemoradiation therapy on patients with advanced esophageal cancer. Methods: We performed a retrospective study of twenty eight cases with inoperable carcinoma of the esophagus treated with definitive chemoradiation at single institute between April 2001 and December 2004. Twenty eight patients with esophageal squamous cell carcinomas were treated with concurrent chemoradiation therapy. Of 28 patients, 22 had stage III disease, 6 had stage II disease, and 26 were males and 2 were females. The median age of the patients was 63.0 years (range, 4475 years). The regimen involved four cycles of chemotherapy, cisplatin, 75 mg/m2 intravenously on the first day of weeks 1, 5, 9, and 13, and 5-fluorouracil, 1,000 mg/m2 per day on the first 4 days of weeks 1, 5. 9. and 13, concurrently with a dose of 5,400 cGy external beam radiotherapy. Results: The overall response rate was 89%. The median overall survival was 24.7 months, the 1-year and 3-year overall survival rate was 71% and 32%, respectively. The 1-year and 3-year progression-free survival rate was 86% and 54%, respectively. Grade 3/4 hematological toxicities included neutropenia in 50% of the patients, anemia in 25%, and thrombocytopenia in 14%. Grade 3 and 4 non-hematological toxicities were less common. Conclusions: These results suggest that concurrent chemoradiotherapy is an effective regimen. (Korean J Med 72:37-43, 2007)