乳房生檢에 依한 乳房疾患의 診斷

盧承武(Seung Moo Rho),孫基燮(Ki Sub Son) 대한외과학회 1979 Annals of Surgical Treatment and Research Vol.21 No.7

주위조직과 심한 유착을 일으킨 소장의 평활근종 1예

노승무(Seung Moo Rho),김인구(In Koo Kim) 대한외과학회 1981 Annals of Surgical Treatment and Research Vol.23 No.7

조기위암의 심달도 진단에서 내시경 검사의 정확도

서승원(Seung Weon Seo),정현용(Hyun Yong Jeong),이승민(Seug Min Lee),이병석(Byoung Seok Lee),김진희(Jin Hee Kim),김남재(Nam Jae Kim),노승무(Seung Moo Rho),송규상(Kyu Sang Song),신경숙(Kyung Sook Shin),조준식(June Sik Cho) 대한내과학회 2001 대한내과학회지 Vol.60 No.4

N/A Background: In order to decide on a strategy of the treatment against gastric cancer, an accurate preoperative evaluation of the depth of tumor invasion is essential. We have studied the depth of invasion in early gastric cancer by endoscopic findings. Methods: The preoperative endoscopic diagnosis of the depth of invasion was compared with pathologic findings in a total of 108 cases with early gastric cancers (EGC) which were confirmed pathologically in resected specimen. Results: Of one hundred eight EGCs, forty-one were elevated type, others were flat-depressed type. There was no relationship between the depth of invasion and macroscopic type of EGC. All of the elevated typed EGCs were differentiated carcinoma. In the depressed typed EGCs, Forty-five percent was differentiated carcinoma and fifty-five percent was undifferentiated carcinoma. The incidence of lymphnode metastasis in submucosal cancers (14.8%) was significantly more than in mucosal cancers (1.6%). Among the submucosal cancers, the incidence of nodal metastasis in double lesions (100%) was significantly more than in single lesions (14.8%). In the elevated typed EGCs, mucosal cancers were small in size less than 3.0 cm (83%), and contained whitish patches, and showed uneveness and erosion. Submucosal cancers were large in size, and contained ulcers, and showed submucosal tumor-like shapes and bridging folds. In the depressed typed EGCs, it was difficult to determine endoscopically the depth of invasion. Submucosal cancers showed the fusion of converging folds and unevenness of the depressed base. The regularity of the depressed base without ulcer was primarily found in mucosal cancer. Conclusion: When the tumor was elevated, the endoscopic diagnosis for the depth of invasion was determined easily by size of the lesion and features of the elevated surface. For the depressed tumor, diagnostic clues were the pattern of the base of the depression and the converging fold, and the endoscopic diagnosis of the depth of invasion was much more difficult than the elevated type EGC.(Korean J Med 60:330- 336, 2001)

乳房生檢에 依한 乳房疾患의 診斷

盧承武 충남대학교 의과대학 지역사회의학연구소 1978 충남의대잡지 Vol.5 No.2

149 patients who were performed breast biopsies on the Department of General Surgery of Chungnam National University Hospital, from fan. 1973 to Jan. 1978, were analyzed. The results were obtained as follows: 1. Of 149 cases, 146 patients (97.9%) were female and 3 patients(2.1%) were male. 2. The most prevalent age group of breast dsease was 3rd decade(35. 5%), followed by 2nd decade(34.8%), and 4th decade(17.4%). 3. The most common lesion was mammary dysplasia(36.2%)followed by malignant tumor(28. 1%)and fibroadenoma(21.4%). Malignant breast tumor was most common in fourties, mammary displasia was most common in the twenties. 4. The most common chief complaint was palpable breast masses(82. 5%), mainly paiiiy less masses. 5. For the most(56.7%), the duration of the symptom was within 6 months, but 10 cases(7.0%) were over 4 years. 6. In physical examination, doctors were able to palpate breast masses in 90.5% of all patients. 7. The most frequent site of lesion was in the upper outer quadrant(48.3%), followed by upper inner quadrant(20. 8%)and areolar area(16. 7%). The lesion of right breast was slightly more frequent than that of left breast. 8. The breast biopsies were performed with local anesthesia in 64. 4% of all patients. and there was not any specific complication. 9. In malignancy, 21 patients(58. 3%)had palpable axiliary lymph nodes, and 18 cases(85. 7%) of them were found out metastatic lesions in histopathological study. In non-palpable cases, the axillary lymph node metastasis was positive in 46. 6%. 10. The accuracy of clinical diagnosis was 68. 2%. On histopathological examination, 24.1% of clinical malignancy was conformed as benign and 9. 3% of clinical benign was diagnosed as malignancy.

항문직장 기형에 대한 임상적 고찰

노승무,장일성 대한대장항문학회 1989 Annals of Coloproctolgy Vol.5 No.1

화농성 간농양의 외과적 배액술 및 경피 삽관 배액술

윤완희,노승무,박혜덕 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

This report is a clinical analysis and study of therapeutic effect between the surgical and percutaneous catheter drainage of 25 cases of pyogenic liver abscesses who were admitted and treated at the Chungnam National University Hospital from February 1986 to July 1988 and the results were as follows 1. The common clinical symptoms and signs in order of frequency were fever(92.0%), R.U.Q. pain(84.0%), anorexia(80.0%), and malaise (76.0%). 2. The liver function test were helpful in diagnosis such as increased alkaline phosphatase (92.0%), leukocytosis(88.0%), increased GCT(80.0%), and increased prothrombin time(68.0%). 3. The liver abcess located in the right lobe in 18 cases (72.0%), left lobe in 4 cases (16.0%), and both lobes in 3 cases(12.0%). And multiple abscesses were found in 6 cases (24.0%). 4. 10 cases of liver abscesses were drained surgically, and percutaneous catheter drainage was performed in 15 cases. 5. Mean days when afebrile after surgical drainage were 4 days, and after percutaneous catheter drainage were 7 days. 6. Mean hospital stay after surgical drainage were 26 days, and after percutaneous catheter drainage were 22 days. 7. Cure rate after surgical drainage was 100.0%, and after percutaneous catheter drainage was 86.7%.

다발성 위 용종이 동반된 가족성 용종증

윤완희,노승무 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

one of the first recognized descriptions of familial polyposis coli(FPC) was recorded in 1847, and its familial nature was outlined in 1882 by Cripps. The main features of the disease and its malignant potential were brought out by Lockhart-Mummery in 1925 and Dukes in 1930 Since then, accompanying extracolonic growth, such as bone and soft tissue tumors, brain tumors, and thyroid cancers, have been described. Gastric and duodenal adenomas and carcinomas have occasionally been described in FPC by different authors, and systemic studies have recently been conducted in Japan on gastric and duodenal neoplasia in FPC, which suggest that the incidence of these tumors may be higher than previously suspected. Accompanying gastric lesions in FPC were reported only sporadically and not systemically. In 1895 Hauser first described multiple polyps of the gastric antrum in an autopsy in a patient with FPC. Early in the 1970’ histologic classification on the gastric lesions in FPC gradually evolved, and a high incidence of accompanying gastric lesions was systemically demonstrated for the first time recently by Japanese investigators and later in the West. This association has not previously described in Korea, probably because to special attempt has been made to detect polyps in these situation. We experienced two cases of polyposis of the stomach in association with FPC in one family, so report them with the brief review of the literatures.

만성 간염 환자에 대한 Malotilate(Kantecs^�)의 임상적 연구

배진선,노승무,송인상 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Authors carried out the clinical study on Malotilate(Diisopropyl 1,3-dithio-2-ylidenemalonate) in patient with chronic liver diseases and in those with elevated SGOT and SGPT over normal range. We selected three patients with chronic liver diseases and six patients with elevated SGOT and SGPT levels, aged from 26 to 61 years. The daily dose was 3 tablets, each tablet containing 200mg of Malotilate(Kantecs). The clinical and laboratory evaluation were made before and after 8 weeks’ treatment. The results were as followings; 1. Serum total protein and albumin were significantly increased from 6.53±0.055gm/dL to 6.69±0.060gm/dL and from 3.43>0.065gm/dL to 3.71±0.096gm/dL respectively after 8 weeks’ administration of Malotilate(p<0.05, p<0.025). 2. Total cholesterol was significantly increased from 161.3±6.69mg/dL to 184.2±6.97mg/dL after 8 weeks’ administration of Malotilate(p<0.025). 3. The values of SGO, SGPT, and ν-GTP were significantly decreased after 8 weeks’ administration of Malotilate(p<0.05). 4. BUN,S-glucose, total bilirubin and alkaline phosphatase were not significantly altered after Malotilate administration. 5. No severe adverse side effects were found during 8 weeks‘ administration of Malotilate. Accordingly, it could said that Malotilate(Kantecs) was effective in the treatment of chronic hepatic parenchymal diseases without causing adverse effects.

수술전 영양결핍상태의 위암 환자에 대한 Solgreen^�(12.5% aminoacid)의 투여 효과

강민규,노승무,장일성 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

The effects of Solgreen (12.5% aminoacid) injection was evaluated in 22 stomach cancer patients with preoperative nutritional deficiency. In this study, 500㎖ of Solgreen was intravenously injected daily for 5 days in 16 patients (A group) and Solgreen was not injected in 6 patients (B group). 24 hour urine creatinine, creatinine-height index (reflects body protein) and serum albumin were measured. The results were as follows: 1. Increase in creatinine-height index was greater in Solgreen injected group than non-injected group. 2. Among group of Solgreen injection, creatinine-height index was higher in post-injection day than in pre-injection day. 3. Increase in serum albumin was greater in Solgreen injected group than non-injected group.

신성고혈압 가토 신장기능에 미치는 Acetylcholine의 영향

김선희,노승무,조경우 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.6

It has long been known that acetylcholine infusion resulted in increases in urine volume, urinary excretion of Na and renal plasma flow. Exact mechanism of renal effects of acetylcholine, however, has not yet been clarified. Since the discovery of endothelium-derived relaxing factor/nitric oxide system, the vascular endothelium has been considered as an endocrine gland. The purpose of the present study was to define the effect of acetylcholine on the renal hemodynamic and tubular function, and the modification of the renal effects of acetylcholine in two-kidney one clip Goldblatt hypertensive rabbits. Intrarenal acetylcholine(0.03-0.3ug/kg/min) increased glomerular filtration rate(GFR, C_Cr), renal plasma flow (RPF, Cpah), urine volume(UV), free water clearance (C_H20), urinary excretion of electrolytes(U_Na V, U_k V) and nitrate(U_No3V) and fractional excretion of Na^+(FE_Na) in unanesthetized rabbits. No change in filtration fraction was observed. Pretreatment with Nω-nitro-L-arginine methyl ester(L-NAME) blocked te acetylcholine-induced renal effects. Acetylcholine infused into the contralateral kidney elicited increases in GFR, RPF, UV, C_H2O, U_Na V, U_k V, U_No3 V and FENa in hypertensive rabbits. The hemodynamic effect was not different between normotensive sham-operated and unilateral nephrectomized rabbits. Acetylcholine-induced tubular effect, however, was significantly accentuated in hypertensive rabbits. Neither the renal hemodynamic nor tubular effects of acetylcholine were observed with pretreatment of L-NAME. These results suggest that the renal tubular effect as well as hemodynamic effect of acetylcholine is mediated through the NO system and that the tubular effect of acetylcholine is accentuated in the early phase of renal hypertension.