Tamoxifen에 대한 자궁내막암세포주의 시험관내 반응에 대한 연구

남선희,이권해,이순곤 대한부인종양 콜포스코피학회 1996 Journal of Gynecologic Oncology Vol.7 No.2

$quot;Medroxyprogesterone acetate(MPA) is one of the most commonly used hormonal agents for the treatment of advanced or recurrent endometrial adenocarcinoma. However, the progesterone receptor content of endometrial carcinoma varies directly to the degree of differentiation and inversely with stage of the tumor. Thus one would predict that MPA therapy would be less effective in advanced and poorly differentiated tumors. In addition, MPA has been shown to reduce progesterone receptor content of both normal and malignant endometrial cells, which could result in loss of hormone responsiveness. Tamoxifen, which is often used in breast cancer therapy, has also been used in the treatment of patients with advanced and recurrent endometrial carcinoma. Tamoxifen is known to have some estrogenic effects at low concentration and one of these effects is induction of progesterone receptor both in normal and malignant endometrium. This property has focused interest on sequential or simultaneous use of tamoxifen and MPA in the therapy of endometrial carcinoma. The growth inhibitory effects of MPA and tamoxifen were tested on six longestabilished endomtrial carcinoma cell lines(HEC-1-A, HEC-1-B, RL 95-2, AN3CA, KLE) and on SCHE-1, a new endometrial carcinoma cell line established in our laboratory. MPA and tamoxifen were used in grouth experiments either alone, simultaneously or sequentially. The MCF-7 breast cancer cell line was used as a control. Only 20% reduction in cell number was archieved after 10 days of exposure to the drug, even with the highest MPA concentration tested(10�) in endometrial carcinoma cell lines. But in MCF-7 cells, 60% reduction in cell number was archieved with the same consentration of MPA(10�). Ten days of feeling with 5� tamoxifen produced a 96% reduction in cell number in MCF-7, a 91% reduction in HEC-A, a 88% reduction in HEC-1-B, a 98% reduction inAN3CA and a 71% reduction in KLE cultures. In SCHE-1 cultures a 83% reduction in cell grouth was seen and no viable cells remained in RL 95-2 cultures after 10 days of feeling with a 5� tamoxifen. In AN3CA cultures, simultaneous exposure to 5� tamoxifen and 5� MPA resulted in RL 95-2, HEC-1-A and HEC-1-B cultures, simultaneous use of these drugs had the same effect as tamoxifen alone, whereas in KLE and SCHE-1 cultures a slight additive growth inhibitory effect was observed. All six endometrial carcinoma cell lines resumed logarithmic growth when medium containing tamoxifen was replaced with medium containing MPA. However, in KLE cultures recovery of logarithmic growth under these conditions was slower than that in the other endometrial carcinoma cultures. Our results show that MPA does not have growth inhibitory effects in these endometrial carcinoma cell cultures, whereas tamoxifen has been shown to have potent growth inhibitory effects on progesterone receptor-negative and therefore MPA-resistant endometrial carcinoma cells. These findings are of special importance since patients who are most likely to need adjuvant therapy for advanced or recurrent endometrial carcinoma are those with estrogen receptor and progesterone receptor negative tumors.

화상환아 어머니의 돌봄 경험에 대한 내용분석

남선희,서지민 여성건강간호학회 2012 여성건강간호학회지 Vol.18 No.4

Purpose: This study was conducted to identify the caring experience of the mothers of childhood burn patients. Methods: Data were collected from 28mothers of childhood burn patients, through semi-structured in-depth interviews. Data were categorized and coded by using content analysis. Results: 27 categories and 102 statements were drawn from 4 domains. The analyzed domains were psychological sufferings, confronted harsh reality, coping method, and future concerns. Psychological sufferings were categorized heartache, sense of guilt, confusion, regred, depression, sorriness, getting hurt, frustration and upset feeling. Confronted harsh nature were categorized econom-ic difficulty, physical burn-out, lack of caring other children and family troubles. Coping method were categorized positive thinking, having hope, ventilating feelingsm accepting the situations, demanding help from family members, changing patterns of the burned child rearing, collecting information for burn treatment, refusing accept the condition of burned child, avoiding personal and social relationship, and reliance on religion. Concerns were categorized con-cerns of growth and adaptation of the burned child, anxiety for scar, concerns of adapting school life and vague future concerns. Conclusion: The nursing interventions for early assessing psychological problems and providing social supports for caring both burn patients and oter siblings should be provided to the mothers of childhood burn patients.

김수악 살풀이춤 연구

남선희,김미숙 무용역사기록학회(구 한국무용사학회) 2014 무용역사기록학 Vol.35 No.-

다원예술 작품의 특성에 관한 연구 -작품 「바이올린 페이즈」, 「마담플라자」, 「아무 일도 일어나지 않는 곳으로의 10번의 여행」을 중심으로-

남선희,조은숙 한국무용예술학회 2019 무용예술학연구 Vol.76 No.4

The form of art is diversified according to the advent of the fourth industrial revolution in which the data for the human and objects are collected and utilized. Focusing on this trend, this study examines the concept and distinct features of pluralism and plural art and analyzes the art works, Violin Phase(2018) by Anne Teresa De Keersmaeker, Madame Plaza(2018) by Bouchra Ouizguen, and 10 matkaa sinne missä mitään ei tapahdu(2019) by collaborated work by Juha Valkeapää and Taito Hoffrén as plural art at National Museum of Modern and Contemporary Art, Korea. Plural art is expanding its fields through in-depth interdisciplinary research. Also, each genre composing plural art works is merged and transcended one, which leads to the dissolution of the genre. Through this discussion, it is very important to count on the present and future of art.

溶媒가 指示藥感度에 미치는 影響

南善嬉,文元周,李善珠,河璟熙 효성여자대학교 약학대학 학도호국단 1982 曉星藥誌 Vol.1 No.-

김수악의 진주교방굿거리춤 연구

남선희 영남춤학회 2013 영남춤학회誌 Vol.1 No.1

이 연구는 경남 무형문화재 제21호로 지정되어 있는 진주교방굿거리춤을 지금은 고인이 된 예능보유자 김수악을 중심으로 연구하였다. 이 춤은 현재 진주지역을 대표하는 전통춤으로 진주교방 소속으로 궁중 연회에 참석하였던 최순이가 교방해체 이 후 진주권번에서 춤사범 역할을 하면서 김수악 에게로 전승되었다. 권번 해체 이 후 김수악은 끊임없는 예술 활동의 결과로 1997년 1월 경남도문화재로 지정받았다. 춤을 고찰하는 데 있어서 수반되어진 연구는 다음과 같다. 첫째, 진주교방굿 거리춤의 생성과 발전과정에 관하여 조사하였다. 둘째, 춤을 구성하고 있는 요소인 춤사위, 복식과 소도구, 반주 음악을 조사하였다. 셋째, 선행 연구된 것을 바탕으로 하여 춤의 미적 양상인 질박미(質朴美), 생동미(生動美), 한아미(閑雅美), 풍류미 (風流美)를 연구하였다. 김수악의 진주교방굿거리춤을 연구해 본 결과 이 춤은 과거 진주권번의 춤사 위를 대부분 고수하고 있는 빼어난 춤으로 기본춤으로 췄던 만큼 한국춤의 근간을 이루는 춤사위가 집결되어 있음을 알 수 있었다. 또한 춤이 담고 있는 한국미의 미적 양상을 살펴봄으로써 한국인들의 정신적 가치와 이 춤의 예술적 가치를 잘 알 수 있었다. 그리하여 이 연구는 초대 보유자인 김수악을 중심으로 한 진주교 방굿거리춤의 올바른 전승과 발전에 도움이 되고, 앞으로 이 춤의 연구자들에게 유익한 연구 자료가 될 것으로 기대된다. This study aims to investigate both the aesthetic consciousness of Jinju Gyobang Gutgeory Dance which has been designated as No. 21 of intangible cultural properties in Gyeongsangnam-do and the characteristic of dance with focusing on the cultural properties holder Kim Su-ak (1925˜ 2009) who was a well-known Korean traditional dancer in Jinju. This researches focused on the aesthetic consciousness of dance are as follows: First, this study examines the creation and a progress of development about Jinju Gyobang Gutgeory Dance. Second, it investigates the dancing constituents such as the dancing motion, the dancing costume, tools and the accompanying music, etc. Third, with based on the former studies, it researches the aesthetic shape about the sense of Jilbakmi, the beauty of freshness and vividity, the sense of Hanami and the sense of Pungryu. This dance is made up of widely two parts as a Gutgeory dance with Gutgeory rhythm and a Sogo dance with the Jajinmori rhythm. At the result of a study on the aesthetic consciousness of this dance, we know that it is a excellent dance with sticking to almost dancing motions in Jinju Kwonbeon, which has had influenced on the basic dancing motions of today. And we know this dance has Korean spiritual values and artistic merits, too. I hope this study is helpful in correct complete transmission and development of Jinju Gyobang Gutgeory Dance.

플립 러닝을 적용한 무용 수업의 교육적 가치에 관한 연구

남선희 한국무용예술학회 2022 무용예술학연구 Vol.87 No.3

This paper discusses the educational value of a dance class applying the flipped learning strategy. Thispaper for developing a dance education program applied with flipped learning to meet the educationalvalue of the future and suggests an educational methodology distinguished from previous methods. The flipped learning-based dance education has following values. First, it fosters talents with inclusiveand creative skills required in future society. Second, it creates an environment where learners think andconsider meanings rather than simply receiving knowledge and information. Third, it is effective forenhancing instructors’ satisfaction and learners learning ability. This study seeks to contribute on the new dance education methodology for enhancing dancer’sself-directed learning ability, improving creativity, and fostering convergent talent to develop the danceeducation in Korea.

무용 전공 대학생을 대상으로 한 ‘플립러닝’ 적용 사례연구

남선희 한국무용예술학회 2023 무용예술학연구 Vol.93 No.4

The purpose of this study is to develop and apply the flipped-learning education program, and toanalyz the impact on improving learners’ creativity. This study further expands to the direction and tasksof dance education. This study is significant in reminding us of the importance and necessity of danceeducation in the era of fostering creative talent as well as suggesting the direction of dance education inthe future. The research method consists of literature review, case studies, and phenomenological qualitativestudy, and this study conducted TTCT creativity test to assess leaners’ creativity improvement. Thisstudy developed an educational program with a total of 12 sessions, and applied it to dance majors. According to the results, participants showed higher scores in fluency, originality, sophistication,abstractness in title, and resistance to hasty conclusion. These were verified that the program increaseds(enhances) leaners’ creativity.

간호대학원생들의 간호철학 수강 경험

남선희,임경춘,구효훈,김인수,김은희,나윤희,배윤혜,최미경 대한질적연구학회 2023 대한질적연구학회지 Vol.8 No.1

Purpose: This study aims to explore the students’ experiences of taking class in nursing philosophy at the graduate school of nursing. Methods: Data were collected through individual in-depth interviews with 18 participants who took nursing philosophy class. Core question was 'What is your experience of taking nursing philosophy class?' Verbatim transcripts were analyzed using content analysis. Results: Qualitative data analysis revealed nine theme clusters in four categories; 'The distance from philosophy that is too far to be friendly’, ‘Finding the academic roots of nursing',’The way to find answers through creative insights' and ‘Presenting a vision of nursing through reflection and maturity'. Conclusion: Nursing graduate students initially encountered challenging thoughts and a sense of detachment from reality when they embarked on their nursing philosophy class. However, nursing philosophy classes are essential for uncovering the academic foundations of nursing science, fostering creative insights, and navigating the actual clinical fields. This is particularly crucial because nurses frequently encounter numerous ethical dilemmas and critical decision-making situations. Nursing philosophy classes should be mandated as a required course for nursing graduate students, as they are responsible for shaping the future of nursing scholars.

긴급선행기간을 이용한 MRP 시스템

남선희,윤원영 대한산업공학회 1991 산업공학 Vol.4 No.1