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다물체 모델링과 musclulo-tendon actuator를 이용한 Knee Joint 구속력의 불확실성 추정 연구
남궁홍(Hong Namgoong),유홍희(Hong Hee Yoo) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
The goal of this study is to expect to force applied at knee joint in the human body by using the Hill-type muscle model and The model, human body, is based on a musculoskeletal model of the human lower extremity in the sagittal plane. To perform this research human leg is modeled by multi-body modeling. This leg model has biarticular muscles, acting on two joints, and the muscles include some of the major muscles, such as hamstring, of the upper and lower limbs. To analysis the uncertainty of the applied forces that act on the knee joint, statistical distributions of human body, leg part, parameters are required and to obtain the parameter’s statistical characteristic of the part sample survey method is employed. Finally using the sensitivity information of the parameter the aim of this paper can be estimated.
다물체 모델링과 근의 특성을 이용한 무릎뼈에 가해지는 압력의 불확실성 추정 연구
남궁홍(Hong Namgoong),유홍희(Hong Hee Yoo) 대한기계학회 2011 大韓機械學會論文集A Vol.35 No.7
본 연구에서는 인체의 하지부를 다물체 시스템으로 모델링하여 무릎관절에 걸리는 구속력의 불확실성을 추정하였다. 일반적으로 근육의 기계적인 특성은 Hill-type muscle model 이 사용되며 여기에 적용되는 인체의 특성과 해부학적인 데이터는 지난 십 수년 동안 크게 발전되었다. 그러나 정확하게 그것들을 안다는 것은 불가능하며 개인마다 다른점을 고려해야 할 필요가 있다. 본 논문에서는 Hill-type muscle model 과 함께 인체의 해부학적인 데이터를 통계 방법론을 이용하여 무릎 관절에 걸리는 구속력의 불확실성을 추정하였다. 초기 앉아있는 자세에서 일어서는 과정에서 작용하는 구속력을 추정하였으며 이때 인체 하지 근육의 특성을 musculoskeleton?actuator 를 이용하여 해석하였다. The goal of this study is to estimate the force acting on the knee joint in the human body by using the Hilltype muscle model based on a musculoskeletal model of the human lower extremity in the sagittal plane. For estimating the force applied, the human leg is modeled using multi-body modeling. This leg model comprises biarticular muscles acting on two joints of the upper and lower limbs, and the muscles include some of the major muscles such as the hamstring. In order to analyze the uncertainty of the applied forces acting on the knee joint, statistical distributions of human body, leg part, parameters are required and to obtain the parameter’s statistical characteristic of the part sample survey method is employed. Finally, by using the sensitivity information of the parameters, the force acting on the knee joint can be estimated.
다물체 모델링을 통한 Hip Joint 위치에 따른 인체 Leg부의 고유진동특성 분석
남궁홍(NamGoong, Hong),유홍희(Yoo, Hong-Hee) 한국소음진동공학회 2010 한국소음진동공학회 논문집 Vol.20 No.8
The goal of this study is to analysis natural frequency for different static postures of human leg. To perform this research human leg is modeled by multi-body modeling for the musculoskeletal system. This leg model has biarticular muscles which acting on two joints and the muscles represents some of the major muscles, such as hamstring, of the upper and lower limbs. To obtain each static equilibrium position energy method is employed and to analysis natural frequency linearization method for constrained mechanical system is employed. Static equilibrium position depends on some parameter or condition such as hamstring stiffness or external force. Making a change these parameter the aim of this research can be performed.
황완균,박형순,함인혜,오미현,남궁홍,김현기,황동휘,허수영,김태영,박용규,김재룡,김진우 생화학분자생물학회 2005 Experimental and molecular medicine Vol.37 No.5
Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further. The purpose of this study is to investigate celular protective activity of coumarin compound, fraxin extracted from Weigela florida var. glabbra, under oxidative stress, to identify genes expressed differentially by fraxin and to compare antioxidative effect of fraxin with its struc-the coumarins, protective effects of fraxin against cytotoxicity induced by H2O2 were examined in human umbilical vein endothelial cells (HUVECs). Fraxin showed free radical scavenging effect at high concentration (0.5 mM) and cell protective effect against H2O2-mediated oxidative stress. Fraxin recovered viability of HUVECs damaged by H2O2- treatment and reduced the lipid peroxidation and the internal reactive oxygen species level elevated by H2O2 treatment. Differential display reverse transcrip-tion-PCR revealed that fraxin upregulated antiapo-ptotic genes (clusterin and apoptosis inhibitor 5) and tumor suppressor gene (ST13). Based on structural similarity comparing with fraxin, seven chemicals, fraxidin methyl ether (29.4% enhancement of viability), prenyletin (26.4%), methoxsalen (20.8 %), diffratic acid (19.9%), rutoside (19.1%), xanthyletin (18.4%), and kuhlmannin (18.2%), enhanced more potent cell via-bility in the order in comparison with fraxin, which showed only 9.3% enhancement of cell viability. These results suggest that fraxin and fraxin-related che-micals protect HUVECs from oxidative stress.