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- 저자 : 나유미(Yumi Ra) (검색결과 2 건)
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갑상선 결절에서의 에스트로겐과 프로게스테론 수용체 발현
나유미,임지수<SUP>1<,SUP>,손장신<SUP>2<,SUP>,최인석,최원준,윤대성,Yumi Ra,M,D,Jisu Im,M,S,<SUP>1<,SUP>,Jangsihn Sohn,M,D,Ph,D,<SUP>2<,SUP>,Inseok Choi,M,D,Ph,D,Wonjun Choi,M,D,Ph,D,and Daesung Yoon,M,D,Ph,D 대한갑상선-내분비외과학회 2009 The Koreran journal of Endocrine Surgery Vol.9 No.1
Purpose: Thyroid cancer is the most common malignancy affecting the endocrine glands. The incidence of his malady has conspicuously increased during the recent years. Thyroid diseases affect women approximately 3 times more often than men, and this incidence decreases after menopause. This gender difference has suggested that the female sex steroids stimulate the growth of the thyroid, the same as for the breast. In the present study, we investigated the expressions of estrogen receptor (ER) and progesterone receptor (PR) in thyroid lesions. Methods: The tissues from 193 human thyroid glands (136 thyroid cancers and 57 adenomatous hyperplasias) were used for the present immunohistochemical assessment of the ER and PR expressions. Results: The incidences of the estrogen and progesterone receptor positive cases were 19.7 and 41.5%, respectively. The incidence of the progesterone receptor positive cases was higher for females (46.5%) than for males (19.4%) however, the expression of estrogen receptor was not different significantly between the females and males. Higher expressions of estrogen and progesterone receptors were detected in the thyroid cancers than in the adenomatous hyperplasias. The PR expression seemed to correlate with the tumor size: a higher PR expression was found in the T3 cancers than in the T2 cancers. Conclusion: Our findings provide new insight that the ER and PR expressions may be related to the pathogenesis and progression of thyroid cancer. (Korean J Endocrine Surg 2009;9:14-18)
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변준석(Junsuk Byun),나유미(Yumi Ra),권성욱(Sungwook Kwon),문주익(Juik Moon),이상억(Sangeok Lee),최인석(Inseok Choi),최원준(Won Jun Choi),민현식(Hyunsik Min),윤대성(Daesung Yoon) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.2
Purpose: Mental illness patients have difficulty of decision-making for treatment due to their own intellectual and socio-economic problems. Thus, doctors have a large role in course of treatment. In this study, we reviewed characters of breast cancer patients with mental illness and tried to define doctors’ role in course of treatment on the basis of our experience. Methods: We analyzed 12 patients with serious mental illness who had a difficulty on self-decision making who were treated for breast cancer between 2001 and 2012. We retrospectively reviewed medical records and relation with guardians. Results: The median age was 52 years old. Five patients were overweight with body mass index over 25 kg/m2. Seven patients had never been married and 11 patients were nullipara. Modified radical mastectomy was performed in all patients except one who received neoadjuvant chemotherapy. Nine patients were recommended chemotherapy, but only 5 patients were treated with chemotherapy and others were hormone therapy only. Four patients received chemotherapy staying with their family. A single patient was treated with chemotherapy stayed nursing home, but accompanying some intimate guardians while staying at hospital. There were two cases of recurrence, and the rest were being closely monitored without recurrence. Conclusion: More detailed and systematic diagnostic and treatment guideline were required which were not depending on each doctor’s and guardian’s unpredictable opinion in treatment of patients with severe mental illness.
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