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갑상선 결절에서의 에스트로겐과 프로게스테론 수용체 발현
나유미,임지수<SUP>1<,SUP>,손장신<SUP>2<,SUP>,최인석,최원준,윤대성,Yumi Ra,M,D,Jisu Im,M,S,<SUP>1<,SUP>,Jangsihn Sohn,M,D,Ph,D,<SUP>2<,SUP>,Inseok Choi,M,D,Ph,D,Wonjun Choi,M,D,Ph,D,and Daesung Yoon,M,D,Ph,D 대한갑상선-내분비외과학회 2009 The Koreran journal of Endocrine Surgery Vol.9 No.1
Purpose: Thyroid cancer is the most common malignancy affecting the endocrine glands. The incidence of his malady has conspicuously increased during the recent years. Thyroid diseases affect women approximately 3 times more often than men, and this incidence decreases after menopause. This gender difference has suggested that the female sex steroids stimulate the growth of the thyroid, the same as for the breast. In the present study, we investigated the expressions of estrogen receptor (ER) and progesterone receptor (PR) in thyroid lesions. Methods: The tissues from 193 human thyroid glands (136 thyroid cancers and 57 adenomatous hyperplasias) were used for the present immunohistochemical assessment of the ER and PR expressions. Results: The incidences of the estrogen and progesterone receptor positive cases were 19.7 and 41.5%, respectively. The incidence of the progesterone receptor positive cases was higher for females (46.5%) than for males (19.4%) however, the expression of estrogen receptor was not different significantly between the females and males. Higher expressions of estrogen and progesterone receptors were detected in the thyroid cancers than in the adenomatous hyperplasias. The PR expression seemed to correlate with the tumor size: a higher PR expression was found in the T3 cancers than in the T2 cancers. Conclusion: Our findings provide new insight that the ER and PR expressions may be related to the pathogenesis and progression of thyroid cancer. (Korean J Endocrine Surg 2009;9:14-18)
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