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김형민,노지은,Sonia Barua,황덕선,나선정,이호성,정지훈,우슬기,김혜원,홍보미,윤지애,김중학,윤영호,박명규,김지아,손의동,이재휘 대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.6
We investigated the combined moisturizing effect of liposomal serine and a cosmeceutical base selected in this study. Serine is a major amino acid consisting of natural moisturizing factors and keratin, and the hydroxyl group of serine can actively interact with water molecules. Therefore, we hypothesized that serine efficiently delivered to the stratum corneum (SC) of the skin would enhance the moisturizing capability of the skin. We prepared four different cosmeceutical bases (hydrogel, oil-in-water (O/W) essence, O/W cream, and water-in-oil (W/O) cream); their moisturizing abilities were then assessed using a CorneometerⓇ. The hydrogel was selected as the optimum base for skin moisturization based on the area under the moisture content change-time curves (AUMCC) values used as a parameter for the water hold capacity of the skin. Liposomal serine prepared by a reverse-phase evaporation method was then incorporated in the hydrogel. The liposomal serine-incorporated hydrogel (serine level=1%) showed an approximately 1.62∼1.77 times greater moisturizing effect on the skin than those of hydrogel, hydrogel with serine (1%), and hydrogel with blank liposome. However, the AUMCC values were not dependent on the level of serine in liposomal serine-loaded hydrogels. Together, the delivery of serine to the SC of the skin is a promising strategy for moisturizing the skin. This study is expected to be an important step in developing highly effective moisturizing cosmeceutical products.
Sonia Barua,김형민,홍성철,유승엽,신도현,이충렬,나선정,김영효,조강희,윤지애,김중학,손의동,이재휘 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.2
This study evaluated the moisturizing effect ofserine-loaded solid lipid nanoparticles (serine-SLN) andpolysaccharide-rich reed (Phragmites communis) rootextract (RRE) incorporated in hydrogel bases. The hydrogelswith serine-SLN and/or RRE were carefully appliedon the volar forearm of human volunteers. Their moisturizingefficacy was evaluated by monitoring conductancevalues using a skin surface hygrometer. The values of thearea under the normalized conductance-time curve(AUCC) were developed and compared as a parameter forthe water holding capacity of the skin. Hydrogels withserine-SLN did not significantly moisturize the skin, whilehydrogel containing 0.25% RRE produced a significantincrease in the moisture content of the skin. However,adding more than 0.25% of RRE into the hydrogel basedecreased the moisturizing effect due to the markedreduction of viscosity. Significantly enhanced moisturizingeffect was observed with the hydrogel containing 0.25%RRE and 3% serine-SLN, with AUCC increased 2.21 timescompared to than blank hydrogel. The results imply thateffective delivery of serine into the skin is possible usinglipid-based nanocarriers and RRE, which could be apromising strategy to moisturize the skin effectively.