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닭과 돼지에서 분리한 Salmonella Typhimurium의 항생제 내성 특성 분석
문자영 ( Ja Young Moon ),김원경 ( Won Kyong Kim ),이건희 ( Kun Hee Lee ),나방주 ( Bang Ju Na ),고재천 ( Jae Cheon Go ),심균섭 ( Kyun Seob Sim ),( Patil Trupti A ),허진 ( Jin Hur ) 한국동물위생학회 2016 韓國家畜衛生學會誌 Vol.39 No.1
Fifty and forty two Salmonella enterica subspecies enterica serovar 52 Typhimurium (ST) strains were isolated from chicken and pigs, respectively, collected from markets throughout Korea from 2008 to 2011. The isolates were investigated for the presence of antimicrobial resistance and multi-drug patterns. All 50 ST isolates from chicken and 42 ST isolates from pigs were resistant to at least one of 13 antibiotics used in this study, 92.0% of ST isolates from chicken and 88.1% of ST isolates from pigs were resistant to three or more antimicrobials. As many as 3 isolates of ST isolates from chicken were resistant to 11 of 13 antimicrobials tested in this study. Only one isolate of ST isolates from pigs was resistant to 10 of 13 antimicrobials. The ACSSuT resistance phenotype was observed in 34% of the 50 isolates and 23.8% of the 42 isolates. Especially, 1 isolate from pigs had the ACSSuTAu. The high rate of antimicrobial-resist and multi-drug resistant (MDR) ST isolation may give rise to crucial public health problems. Therefore, control of antimicrobial use, and continuous monitoring of antimicrobial resistance and MDR patterns among Salmonella isolates in chicken and pig farms is necessary to ensure public health.
기관지 천식에서 Nimesulide의 안정성 및 내인성
나방주,박성주,이식,김신재,최광호,이용철,이양근 의과학연구소 2000 全北醫大論文集 Vol.24 No.1
Background : In most patients with aspirin and non-steroidal anti-inflammatory drug intolerance, anti-inflammatory treatment is a clinical problem. Nimesulide, a newly available anti-inflammatory drug, the safe use of which in aspirin-intolerant patients has been reported anecdotally and is based on its peculiar mechanism of anti-inflammatory action and its weak inhibition of cyclooxygenase. In this study we evaluate the safety and tolerance of a new non-steroidal anti-inflammatory drug, nimesulide(Aulin, Boehringer Mannheim, Italia), in bronchial asthma patients compare with control patients. Material and methods : Total twenty patients(11 bronchial asthma, 9 control patients) were enrolled in this open, non-comparative, monocenter study. The enrolled airway disease patients presented headache, joint pain, pleuritic chest pain, etc. Nimesulide was administered orally at dose of 200㎎ a day(bid) before meals for 7 to 10 days. Other anti-inflammatory drugs were excluded in this study. Results : Successful clinical response observed in 8 asthma patients(72.7%). The tolerance was good in 19 patients(85.0%). Three patients(15.0%) experienced mild epigastric discomfort. Exacerbation of pulmonary symptoms was not developed in both groups. Conclusion : Nimesulide was proved to be effective, safe and tolerable non-steroidal anti-inflammatory drugs in the treatment of the symptoms associated with bronchial asthma.