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고 유량 혈액 투석 시스템에서 박동류 펌프에 대한 대류 향상에 관한 연구
최대석,임기무,이정찬,이사람,문초혜,최혁,민병구,김희찬,Choi, D.S.,Um, K.M.,Lee, J.C.,Lee, S.R.,Mun, C.H.,Choi, H.,Min, B.G.,Kim, H.C. 대한의용생체공학회 2008 의공학회지 Vol.29 No.5
High-flux dialysis treatment removes various toxins via diffusion as well as convection, which is induced by ultrafiltration and backfiltration. In this study, in vitro (Using the distilled water and the bovine's blood) comparison test was performed to determine whether utilization of a high flux dialyzer paired with different pumps would increase the efficiency of convection. At the same blood flow rates, a pulsatile pump and a roller pump were employed to propel the distilled water and bovine whole blood to a high flux dialyzer. Pressures at the dialyzer inlet and outlet in the blood circuit and in the dialysate circuit were measured, respectively. From these data, we calculated the transmembrane pressure and predicted the ultrafiltration and backfiltration rates developed by both pumps. Using the bovine's blood experiment, ultrafiltration and backfiltration rates were 1.6 times higher with the pulsatile pump than with the roller pump. We conclude that utilization of a pulsatile pump in high flux hemodialysis treatments increases ultrafiltration volume, compared with a roller pump under conditions of the same blood flow rate.
자성 비드를 이용한 소형 유전자 추출기의 자동제어 시스템의 설계 및 구현
김상호,김종대,김희찬,김종원,Kim, S.,Kim, J.D.,Kim, H.C.,Kim, J. 대한의용생체공학회 2009 의공학회지 Vol.30 No.4
An automatic control system is proposed and implemented for a miniaturized DNA extraction system using magnetic bead. A host-local system is employed for the accommodation of the graphical user interface and the basic control function. The functional partitioning into the local and the host system is discussed. The control functions are classified and formalized for the flexible control scenario, which is the input of the proposed system. As the proposed scenario is consists of the sequence of the user-centric actions, the user goal can be easily programmed and modified. The DNA extraction performance of the implemented system was compared with the existing silica-membrane-based method, resulting in the comparable concentration and purity of the extracted DNA. The proposed system is currently being utilized for the development of the DNA extraction system only changing scenario, without any alteration of the system.