서부 경남지역에서의 피부 악성종양에 대한 임상연구

윤태진,김행석,오지원,김태흥 ( Tae Jin Yoon,Haeng Seok Kim,Chee Won Oh,Tae Heung Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.5

Background: In Korea, especially in the Western Gyeongnam area, the exact prevalence and characteristics of skin tumors are unknown. The increasing incidence of skin cancer has been attributed to the increase iin exposure of the population to sunlight and other factors, such as chemicals or viruses. Objective : The aim of this study is the investigation of clinical and histopathological observation of cutaneous maligrant tumors in the Western Gyeongnam area. Mgthods : This study was based on the analysis of 125 cases of cutaneous malignant tumor patients between January, 1990 and December, 1996 at the Department of Dermatology, Gyeongsang National University Hospital. Results. The results are summarized as follows: 1. The mean incidence of cutaneous malignant tumors in the total number of outpatients was 0.15% (125/84,208). 2. The age of onset was quite varied but the majority of cases, 119 cases(95.2%), were over 40 years old. The ratio of men to women was 1.05:1. 3. Among the 125 cases of cutaneous malignant tumors, the most frequently observed tumor was basal cell carcinoma, 50 cases(40.0%). The next was squamous cell carcinoma, 42 cases(33.6%). 4. We observed three aases of metastasis in squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. Two cases(squamous cell carcinoma and malignant, melanoma) were metastasized into the regional lymph nodes. One case(basal cell carcinoma) into the ribs. Conclusions : We investigated the clinical observations of 125 cutaneous malignant tumor patients in our clinic and made a comparative study. This data will be available for the study of cutaneous malignant tumors in the future. (Korean J Dermatol 1997;35(5): 956-962)

여성에서 나타난 선천성 이각화증 1 예

김지연(Chi Yeon Kim),김태흥(Tae Heung Kim),윤태진(Tae Jin Yoon) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.10

Dyskeratosis congenita is a rare inherited multisystemic condition involving mainly the ectoderm. Clinically it is characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Complications are predisposition to malignancy and bone marrow involvement with pancytopenia. Dyskeratosis congenita occurs predominantly in male by a male to female ratio of 13:1. The mode of inheritance is uncertain. Several studies support X-linked recessive transmission, but its occurrence in females suggests genetic heterogeneity. We report a rare case of dyskeratosis congenital in a woman. (Korean J Dermatol 2001;39(10): 1162~1165)

다양한 부속기 종양을 동반한 피지선 모반

김지연 ( Chi Yeon Kim ),윤태진 ( Tae Jin Yoon ),김태흥 ( Tae Heung Kim ),오지원 ( Chee Won Oh ) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.9

Nevus sebaceous is a rumor of primary epithelial germ cells that is generally first noticed at birth. Clinically, there is a yellowish waxy plaque with overlying alopecia on the scalp. Less commonly, it can be seen on the face, trunk, and extremities. Syringocystadenoma papilliferum is nthe most common benign growth from nevus sebaceous, whereas basal cell careinoma is the most frequent malignancy. The proportion of the malignant tumors occurring on nevus sebaceous is highly variable according to the published series, and there are contrevenies on the nature of these neoplasms. We experienced a rare case of nevus sebaceous, superimposed of 5 multiple type tumors at the comparatively young age; syringocystadenoma papilliferum, basal cell carcinoma, nevocellular nevus, sebaceous adenoma, and syringoma. We treated the patient with total excision, and followed up during 1 year. The patient showed no recurrence.

광과민 질환에 대한 임상 연구 -지난 9년간 경상대학병원 피부과 외래를 방문한 환자들을 대상으로 한 연구-

이승현 ( Seung Hyun Lee ),강진수 ( Jin Soo Kang ),윤태진 ( Tae Jin Yoon ),김태흥 ( Tae Heung Kim ) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.9

N/A Background : Although dermatologists may encounter photosensitivity patients commonly, most dermatologisis are not familiar with diseases manifeting photosensitivity and there is still no clinical study on photosensitivity disease in Korea. Objective : We tried to investigate incidences and sorts of photosensitivity diseases with clinical informations. Methods: We performed a retrospective clinical review of patients who had photosensitivity as a chief complaint in the department of dermatology, Gyeongsang National University hospital from 1991 to 2000. Results: There were a variety of diverse photosensitive diseases in this clinical study. Drug induced photosensitivity including phototoxicity and photoallergy were fairly common(19.7%), and causative drugs were various including antibiotics, diuretics and eve medicinal herb. We could find co-occurrence of some diseases in photosensitivity patients (39.3%), most of which were chronic degenerative disease. Conclusion : Further clinical studies will be needed to feet additional and standardized information in Korea, and precise clinical work-ups would be necessary to differentiate variable spectrums of photosensitivity diseases we showed in this study.

적혈구 형광현미경검사로 진단한 적혈구 조혈성 프로토포르피린증

허은필(Eun Phil Heo),이원섭(Won Sup Lee),윤태진(Tae Jin Yoon),김태흥(Tae Heung Kim),김성언(Seong Eon Kim) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.1

Erythropoietic protoporphyria (EPP), caused by decreased activity of the enzyme ferrochelatase, is characterized clinically by burning photosensitivity beginning from childhood, and chemically by excessive amounts of red blood cell protoporphyrins. 1-10% of EPP patients develop potentially fatal protoporphyric hepatic failure. The diagnosis of EPP had been missed in many cases when traditional solvent extraction qualitative screening test was used for blood porphyrins, and use of fluorescence microscopy improved this problem. We report a case of EPP screened by fluorescence microscopy of erythrocytes in a 50-year-old man complaining of photosensitivity. We recommend fluorescence microscopy could be the screening test of choice for the detection of increased red blood cell porphyrins. (Korean J Dermatol 2002;40(1):63~67)

각화극세포종의 5-Fluorouracil 과 Methotrexate 병변내 주사 치료

김태흥,윤태진,김지연 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.10

Among many treatment modalities of keratoacanthoma, excisional surgery is preferred by most dermatologists. In some cases, surgical excision may result in functional or cosmetic problems, particularly in large or giant keratoacanthoma, or keratoacanthoma arising from cosmetically critical area. We herein report two cases of keratoacanthoma successfully treated with intralesional injections of 5-fluorouracil or methotrexate. We suggest that the intralesional injection is a simple and effective treatment for keratoacanthoma that is difficult to remove surgically, and it may offer greater efficacy with a rapid clinical response.

Localized perineal papules and plaques with acantholytic histology 1 예

이승헌,김태흥,윤태진,박선후 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.10

Localized perineal papules and plaques with acantholytic histology is characterized clinically by discrete and grouped papules, which are localized to the perineal or perianal areas. Histologically it shows focal suprabasal acantholysis. A 51-year-old man was referred to our department for verrucous skin lesions confined to perineal and perianal areas. Histopathologic findings of verrucous papule showed severe intraepidermal acantholysis. Although we do not know the precise nature or the incidence of this disease, localized perineal papules and plaques with acantholytic histology should be included in the differential diagnosis of verrucous papules in perineal or perianal areas.

형질세포 구순염 1예

이승현,이정희,윤태진,김태흥 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.9

Plusma-cell cheilitis, a benign, inflammatory condition, is chacterized by polyclonal plasma cell infiltration in the dermis. It presents as circumscribed flat o elevated patches of erythema, usually on the lower lip in an elderly person. Plasma-cell cheilitis is the counterpart of Zoon's plasma-cell balanitis. A 63-year-old Korean man had an erythematous, erosive patch on his lower lip. By skin biopsy and immunoperoxidase staining to anti-K and λ light chain, he was diagnosed as plasma cell cheilitis. He showed positive result in photopatch test to 6-methyl coumarine. His skin lesion improved after avoiding s exposure. chewing gun and candy, and by intralesional injections of triamcinolone acetonide.