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방사선 방어효과가 있는 인삼단백성분이 MMS에 의해 유도된 자매염색분체 교환과 염색체이상에 미치는 영향
김춘미,박헤숙 ( Choon Mi Kim,Hae Sook Park ) 생화학분자생물학회 1988 BMB Reports Vol.21 No.4
Radioprotective ginseng protein was purified from Korean ginseng and its effects were studied on the frequencies of sister chromatid exchanges (SCE) and chromosome aberrations (CA) induced by MMS in CHO-K1 cells. In SCE study, as the dose of MMS was increased from 10^(-5)M to 10^(-3)M, the frequency was markedly increased to several fold. When the radioprotective ginseng protein was added to the cells at 500㎍/㎖, before and after MMS treatment, the frequency was decreased significantly at all MMS doses and more in the case of pre-treatment especially at the concentration of 10^(-3)M MMS. When the concentration of the ginseng protein was increased from 100 to 500㎍/㎖, at each dose of 10^(-5)M, 10^(-4)M and 10^(-3)M MMS, the reduction of SCE frequency was sharp at the first addition of 100㎍/㎖ and then reached a sort of plateau at all higher doses. At 10^(-3)M MMS, the pre-treatment resulted in significantly lower SCE than the post-treatment. In CA study, as the dose of MMS was increased from 10^(-3)M to 5×10^(-3)M, the frequency was increased sharply to many fold. When the radioprotective ginseng protein was added after MMS treatment, the frequency was reduced significantly at all MMS doses. When the concentration of the ginseng protein was increased from 200 to 500㎍/㎖, at each dose of 10^(-3)M, 2.5×10^(-3)M and 5×10^(-3)M MMS, the reduction of CA proceeded rather continuously at all three doses. The results seem to suggest that the radioprotective ginseng protein reduces DNA damage that leads to the formation of SCE and CA, possibly by acting at certain steps of repair processes and/or by stabilizing the DNA molecule.
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중환자실에서 이루어지는 간호사 인수인계 실태 및 인수인계에 대한 평가
김춘미,김은만,고지운,Kim, Chun Mi,Kim, Eun Man,Ko, Ji Woon 한국중환자간호학회 2015 중환자간호학회지 Vol.8 No.2
Purpose: This study identified the current status and perception of intensive care unit nurses' handover. Methods: A cross sectional descriptive survey was employed. The population included nurse managers and staff nurses who worked in intensive care units in hospitals with more than 500 beds and excluded nursing homes, psychiatric hospitals, and military hospitals. Results: Of the nurses, 61.7% were satisfied with the current handover method, 68.36% had no handover-related guidelines, and 83.2% of them perceived that the handover was important for patients' safety. The most frequent cause for errors related to handover was that the "nursing workload is heavy." The nurses perceived that their handover was informative ($5.62{\pm}0.79$) and efficient ($5.04{\pm}0.98$). The variables associated with their perception of the handover were the level of satisfaction with the current handover method, existence of handover guidelines, and importance of handover for patient safety. Conclusion: The development of standardized handover guidelines, especially for intensive care units, is necessary to reduce handover time and errors and to improve handover quality for patients'safety and high standards of nursing care.
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김춘미,박혜숙,Kim, Choon-Mi,Park, Hae-Sook 생화학분자생물학회 1988 한국생화학회지 Vol.21 No.4
CHO-K1 세포에 MMS를 가하여 높은 반도의 자매염색분체교환 (SCE)과 염색체이상 (CA)을 유도 한 후, 한국인삼으로부터 분리, 정제한 방사선 방어효과가 있는 인삼단백질을 가하여 그 영향을 연구 하였다. SCE에 대한 연구에서, MMS의 용량을 $10^{-5}M$에서 $10^{-3}M$까지 증가시킴에 따라 그 빈도는 몇 배로 증가하였으며, 인삼단백질 500 ${\mu}g/ml$을 MMS 처리전과 후에 배양세포에 가했을 때, 그 빈도는 유의성 있게 감소하였다. 또한 $10^{-3}M$ MMS에서는 전처리의 경우에 그 효과가 더 현저하였다. 인삼단백질의 양을 100에서 500 ${\mu}g/ml$까지 증가시켰을 때, $10^{-5}M$, $10^{-4}M$, $10^{-3}M$ MMS의 각 농도에서, 그 빈도는 처음 100 ${\mu}g/ml$ 첨가시에는 크게 감소하였으나, 그 이상의 농도에서는 거의 plateau를 나타내었다. $10^{-3}M$ MMS에서는 전처리의 경우 후처리보다 SCE 빈도의 감소가 더 현저하였다. CA에 대한 연구에서, MMS의 용량을 $10^{-3}M$에서$5{\times}10^{-3}M$까지 증가시킴에 따라 그 빈도는 수배로 증가하였으며, 인삼단백질 500 ${\mu}g/ml$을 MMS 처리 후에 가했을 때 그 빈도는 유의성있게 감소하였다. 인삼단백질의 양을 200에서 500 ${\mu}g/ml$까지 증가시켰을 때, $10^{-3}M$, $2.5{\times}10^{-3}M$, $5{\times}10^{-3}M$ MMS의 각 농도에서, 그 빈도는 계속적으로 감소하였다. 이 결과는 방사선 방어작용이 있는 인삼단백질이 SCE와 CA로 연결되는 DNA 상의 손상을 감소시킴을 의미하며, 이러한 효과는 이 단백질이 DNA repair 과정의 어느 단계에 작용하거나, DNA 분자 자체를 안정화시킴으로써 나타날 수 있다고 생각된다. Radioprotective ginseng protein was purified from Korean ginseng and its effects were studied on the frequencies of sister chromatid exchanges (SCE) and chromosome aberrations (CA) induced by MMS in CHO-K1 cells. In SCE study, as the dose of MMS was increased from $10^{-5}M$ to $10^{-3}M$, the frequency was markedly increased to several fold. When the radioprotective ginseng protein was added to the cells at $500\;{\mu}g/ml$, before and after MMS treatment, the frequency was decreased significantly at all MMS doses and more in the case of pre-treatment especially at the concentration of $10^{-3}M$ MMS. When the concentration of the ginseng protein was increased from 100 to 500 ${\mu}g/ml$, at each dose of $10^{-5}M$, $10^{-4}M$ and $10^{-3}M$ MMS, the reduction of SCE frequency was sharp at the first addition of 100${\mu}g/ml$ and then reached a sort of plateau at all higher doses. At $10^{-3}M$ MMS, the pre-treatment resulted in significantly lower SCE than the post-treatment. In CA study, as the dose of MMS was increased from $10^{-3}M$ to $5{\times}10^{-3}M$ the frequency was increased sharply to many fold. When the radioprotective ginseng protein was added after MMS treatment, the frequency was reduced significantly at all MMS doses. When the concentration of the ginseng protein was increased from 200 to 500 ${\mu}g/ml$, at each dose of $10^{-3}M$, $2.5{\times}10^{-3}M$ and $5{\times}10^{-3}M$ MMS, the reduction of CA proceeded rather continuously at all three doses. The results seem to suggest that the radioprotective ginseng protein reduces DNA damage that leads to the formation of SCE and CA, possibly by acting at certain steps of repair processes and/or by stabilizing the DNA molecule.
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김춘미,Kim, Chun-Mi 한국농촌간호학회 2009 한국농촌간호학회지 Vol.4 No.1
By the rural area health care special law in 1980, Primary health care posts were established in rural areas as fundamental elements of the national health system. Nurses have been deployed to the posts after taking an education course mandated by the special law. However, health care posts have confronted environmental changes over the past 30 years such as an aging and decreasing rural population and advanced traffic systems, which make it necessary to reshape their form and role. Therefore, some guidelines are suggested for future role enlargement of health care posts by analyzing their current management and duties. The guidelines are as follows: 1) enlarging the portion of prevention and management of chronic degenerative diseases, 2) development and practice of diverse health promotion programs, 3) extension of primary health care for the increasing older population, 4) development of health programs for married immigrants, 5) practice of timely maternal child health programs, 6) development of adequate health care posts for low-income people in rapidly urbanizing rural areas and in poor areas in big cities, and 7) revision of laws and institutional arrangements for the role enlargement of health care posts to match social changes and customer needs.
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김춘미(Choon Mi Kim),한규선(Gyu Sun Han) 대한약학회 1985 약학회지 Vol.29 No.5
Ginseng proteins were isolated and partially purified to obtain two fractions, namely GI and GII. Radioprotective effects of these fractions were examined on gamma-ray irradiated ICR mice by observing 30-day survival rates after irradiation. Also investigated were the effects of GI fraction on the recovery of radiation damage. As the results, the GI fraction showed strong protection against radiation indicated by the increment of 30-day survival rates, while the GII fraction did not. The GI fraction enhanced the recovery of body and splenic weights and increased the amount of DNA in liver significantly. It also helped to recover the damage done on erythrocytes by increasing the number to normal in short period, however, it had no effect on the recovery of leukocyte counts.
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