폐에서 발생한 원발성 악성 혈관주위세포종

김재선 ( Jae Seon Kim ),진윤태 ( Yun Tae Jin ),인광호 ( Kwang Ho In ),강경호 ( Kyung Ho Kang ),김준석 ( Jun Suk Kim ),유세화 ( Se Hwa Yoo ) 대한결핵 및 호흡기학회 1991 Tuberculosis and Respiratory Diseases Vol.38 No.2

산화질소가 Guinea Pig 의 Oddi 괄약근 운동에 미치는 영향에 관한 연구

김재선(Jae Seon Kim),현진해(Jin Hai Hyun),박영태(Young Tae Bak),김창덕(Chang Duck Kim) 대한내과학회 1996 대한내과학회지 Vol.50 No.1

N/A Objectives: Recent studies indicate that intric oxide (NO) is a novel inhibitory neurotransmitter involved in several functions of many gastrointestianl organs. But only a few studies regarding its effect on sphincter of Oddi (SO) function were done until now. The aims of this study were to determine the effect of NO on motility of SO in L-arginine, a substrate of NO, inhibits SO motility, if NO is an important transmitter controlling the motility of SO. Methods: After laparotomy, a pressure-monitoring perfusion catheter was introduced into the lumen of SO through common bile duct and another catheter into the 2nd portion of duedenum through low body of stomach, and tonic pressure and phasic contractions of SO were monitored with TDS 8000 Manometry System(Sandhill Scientific, USA) during baseline period and after infusing a specific NO synthase inhibitor, N-nitro-L-arginine(Sigma: L-NNA, 5 mg/kg body weight), and cholecystokinin-8(Squibb: CCk, 25 or 50pmol/kg body weight). Results: 1) Tonic pressure and phasic contractions were significantly increased after administration of the NO synthase inhibitor. The response to CCk was enhanced by the NO synthase inhibitor. 2) Addigion of the substrate of NO suppressed the NO synthase inhibitor-induced increase of the tonic pressure and phasic contractions, and also suppressed the NO synthase inhibitor-induced enhancement of the response to CCK. 3) Administration of only NO substrate did not significantly change the tonic pressure and phasic contractions of resting stage and the response to CCK. Conclusion: These findings suggest that NO is an important neurotransmitter that is responsible for the inhibitory neural regulation of the SO motility. But the administration of the substrate of NO, L-arginine, alone does not seem to be useful for the management of SO dysfunction

한국교회 공동체의 신정론: 분열의 아름다움과 악

김재선(Jae-Seon Kim) 연세대학교 신과대학(연합신학대학원) 2023 신학논단 Vol.111 No.-

저용량 Amoxicillin , Metronidazole , Omeprazole 병합투여에 의한 소화성궤양의 치료

김재선(Jae Seon Kim),박영태(Young Tae Bak),김진호(Jin Ho Kim),김종극(Jong Guk Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

N/A Background/Aims: Anti-Helicobacter pylori(H. pylori) therapies with few side effects are needed. We studied the effectiveness of low dose combination of amoxicillin, metronidazole, and omeprazole for treatment of ulcer patients. Methods: Patients with gastric or duodenal ulcer received amoxicillin(500 mg b.I.d.), metronidazole(125 mg b.I.d.), aod omeprazole(20 mg at bedtime) for 2 weeks. Endoscopic examinations were perforrned before treatment and at 4 weeks, 3 months, 6 months, 9 months and 1 year after ending antimicrobial therapy. H. pylori status was confirmed by CLO test. Results: 91 patients(72 men and 19 women) with a mean age of 45.2 years(range 19-81) were enrolled. There were 54 Dus, 32 Gus, and 5 with both. At 2 weeks, the compliance rate was 100%, and no side effects was noted. Of 69 patients(40 Dus, 25 Gus, and 4 with both) who had undergone endoscopy at 4 weeks after ending antimicrobial therapy, the ulcer healed in 55 patients(34 Dus, 19 Gus, and 2 with both), and H. pylori infection was cured in 49 patients(27 Dus, 19 Gus, and 3 with both). And so the healing rate of ulcer and cure rate of H, pylori at 4 weeks after ending antimicrobial therapy was 79.7%(DU 85.0%, GU 76.0%, and Both 50%) and 71.0%(DU 67.5%, GU 76.0%, Both 75%) respectively. 28(18 Dus, 9 Gus, and 1 Both) of the healed ulcer patients in whom H. pylori had been cured had been followed respectively up for 1 year; ulcer recurrence and H. pylori reoccurrence were 2(1 DU, 1 GU) and 3(1 DU, 2 Gus), thus ulcer recurrence and H. pylori reoccurrence was 7.1% and 10.7%, respectively. 8 patients(7 Dus, 1 GU) of the healed ulcer patients in whom H. pylori had not been cured were followed up during 1 year; there were 6 ulcer recurrences(6 Dus), and so ulcer recurrence was 75.0%, but natural eradication of H. pylori was not. Conclusions: The combination of amoxicillin, metronidazole, and omeprazole even at the low dose prescribed may be one of an effective therapy regimen with excellent compliance rate for peptic ulce.r. (Korean J Gastroenterol 1997;29:301 - 309)

하부대장 과형성 용종의 의의

김종극(Jong Guk Kim),이창홍(Chang Hong Lee),박영태(Young Tae Bak),김진호(Jin Ho Kim),김재선(Jae Seon Kim),변관수(Kwan Soo byun),지종대(Jong Dae Ji),송훤택(Hwun Taig Song) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4

N/A Adenomatous polyps are known to be precursors for cancer, and identifying of persons with adenomatous polyps is practically important because these individuals should constitute a disproportionate percentage of persons destined to have colorectal cancer. There is enough reason to believe that regclar endoscopic screening of persons with adenomatous polyps and removal of these polyps can reduce the incidence of colorectal cancer. But hyperplastic colonic polyps are generally regarded as being of little or no clinical consequence. Recentlyl, however, controversy has not been settled down on the significance of distal colonic hyperplastic polyp as a marker for proximal colonic adenomatous polyp (s). To establish the prevalence of proximal neoplasms in subjects with or without hyperplastic polyps in distal colon and to determine whether the presence of hypcrplastic polyps in the distal colon could serve as a market for proximal synchronous adenomatous colonic polyps, we prospectively analyzed 895 consecutive subjects who were examined with colcnoscopy between March 1990 and October l992. 191 of 895 subjects (21.4%) had one or more colonic polyps. The prevalence of adenomatous polyps alone was 10.2% hyperplastic polyps 8.4%, and both 1.9%. The proportion of subjects with both proximal adenomatous polyp and distal hyperplastic polyps (6.0%) was not significantly different from the proportion of those without distal hyperplistic polyps(5.1%), But subjects with distal adenomatous polyps (s) were si!nificantly more likely to have proximal adenomatous polyp (s) than those without distal adenomatous polyp (s). The result of this study suggests that hyperplastir. polyps of distal colon do not serve as a marker for neoplastic polyps of proximai colon.

담관내압 측정검사로 진단한 Oddi 괄약근 협착

김재선(Jae Seon Kim),조은래(Eun Rae Jo),권소영(So Young Kwon),변관수(Kwan Soo byun),박영태(Young Tae Bak),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1

Unexplained chronic and recurrent biliary type abdominal pain, with or without prior histo- ry of cholecystectomy, in the absence of structural changes in pancreatobiliary anatomy is often attributed to an abnormal pressure profile of the sphincter of Oddi. This symptom com- plex is often attributed to the syndrome of sphincter of Oddi dysfunction. The diagnosis of this disorder has been suggested by the symptom compex, exclusion of anatomic biliary tract disease, dilatation of common bile ducts or delayed drainage of contrast media from the bile ducts during the endoscopic retrograde cholangiography. But, more recently developed tech- nique, endoscopic manometry of the sphincter of Oddi, appears to be most sensitive for detect- ing increases in biliary sphincter pressures, even in the presence of nondilated bile ducts. This syndrome may be further subdivided into sphincter of Oddi stenosis that indicates a structual narrowing of the sphincter of Oddi and sphincter of Oddi dyskinesia that is defined as abnormal sphincter of Oddi motor activity. The basal pressure, which is elevated in both stenosis and dyskinesia of the sphincter of Oddi, is the most widely agreedupon abnormality. Administration of smooth muscle relaxants may help to distinguish between the two enti- ties; these agents do not have any effect on a fixed stenosis but may inhibit the elevated sphincter tone in dyskinesia. 3Ve report a case of the sphincter of Oddi stenosis diagnosed by biliary manometry. (Korean J Gastroenterol 1994; 26: 200 205)

내시경 검사시 Phenol Red 분무에 의한 Helicobacter pylori 감염 진단의 의의

김종극(Jong Guk Kim),이창홍(Chang Hong Lee),박영태(Young Tae Bak),김진호(Jin Ho Kim),원남희(Nam Hee Won),김재선(Jae Seon Kim),변관수(Kwan Soo byun) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1

N/A A strong association between Helicobacter pylori (H. pylori) and chronic active inflammation of the gastric antrum and duodenal ulceration has been recognized. Although various rnethods have been proposed to detect this microorganism, no unanimity exists among investigators concerning which method represents a gold standard. H. pylori producee urease that converts urea to ammonia which then raises the pH, therefore we have utilized an endoscopic spray technique using phenol red (pH indicator) in vivo to assess H. pylori infection itself and its distribution. 87 patients with dyspepsia were pre-medicated with ranitidine 150 mg p.o. 3 houre before endoscopy to maintain a gastric pH between 3-6. During endoscopy, 20 ml of a mixture containing 0.05% phenol red and 0.5% urea was sprayed over the antral mucosa using a spray catheter. It was defined as positivc if any area of the mucosa turned red within 3 min after spraying. Antral biopsies were taken from all patients. Biopsies were assessed in a blind fashion after H&E, Giemsa and Warthin-Starry silver stain. The phenol red positive patients were 54.0%, and diffuse pattern of positive staining was 85.1% and regional pattern was 14.9%. Diagnostic sensitivity and specificity of the endoscoic spray technique were 87.2%. and 85.0% respectively. In conclusion, the endoscopic phenol red spray technique may be one of the simple and useful screening tests for diagnosis of H. pylori infection and for dilineating its probahle pattern of distributionvn gastric mucosa in vivo, but this method seems not useful for confirmatory diagnosis of H. pylori infection and needs further study.

반복되는 담도성 산통을 호소하는 환자에서 담관내압검사와 담낭스캔의 의의

김재선(Jae Seon Kim),정문기(Moon Gi Chun),이성준(Seong Jun Lee),김경민(Kyoung Min Kim),변관수(Kwan Soo byun),박영태(Young Tae Bak),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5

N/A Background/Aims: Tbis study was aimed to evaluate the clinical significance of the sphincter of Oddi manometry (SOM), cholescintigraphy, endoscopic sphincterotomy(EST), and cholecystectomy in patients complaining of recurrent biliary-type abdominal pain. Methods: 20 patients with recurrent biliary-type abdominal pain not explained by conventional diagnostic studies were sampled. All the patients with manometrically verified sphincter of Oddi dystunction(SOD) and some patients with normal or failed manometry underwent EST. Among those with normal or failed manometry laparoscopic cholecystectomy was performed to patients with acalcu)ous cholecystopathy(ACP) diagnosed by cholescintigraphy. Results: Of 26 sessions of SOM tried in all the 20 cases, 2l sessions in 17 cases were technically successful. Among those 17 patients, SOM was abnormal in 9 cases(6:sphincter of Oddi dyskinesia; 3:sphincter of Oddi stenosis). Four of five patients undergoing cholescintigraphy in patients with normal or t'ailed manometry were verified as ACP. The procedure-related pancreatitis occurred in 7/26 sessions after SOM and in 3/12 sessions after EST. In 1 case, a micro-perforation followed EST. All these patients with complications recovered uneventfully. Mean duration of fo]low-up was 13.5(range 7 -24) months. EST was of benefit to 7 of 9 patients with manometrically verified SOD and also to all 3 patients with normal or failed manometry undergoing EST. Laparoscopic cholecystectomy was of henefit to all 3 patients with ACP undergoing cholecystectomy. Conclusions: Extensive diagnostic procedures such as SOM and cholescintigraphy and proper therapy according to their results should be considered with patients complaining of recurrent biliary-type abdominal pain not explained by other conventional diagnostic studies. (Korean J Gastroenterol 1995;27: 563 - 572)

계몽주의 시대 문학 개혁의 산실로서의 떼르뚤리아 연구

김재선 ( Jae Seon Kim ),박채연 ( Chae Yeon Park ) 韓國世界文學比較學會 2010 世界文學比較硏究 Vol.31 No.-

Este estudio trata de las tertulias literarias del siglo XVIII espanol tales como la Academia de Tripode, la Academia del Buen Gusto, la tertulia de la Fonda de San Sebastia..n y los salones de Olavide. Estudiamos sus historias,sus caracteri..sticas, sus participantes y sus influencias en la literatura y la sociedad de la e..poca ilustrada. Las tertulias estudiadas llevaron a cabo un papel importante en la sociedad espanola de entonces como la esfera pu..blica para crear y divulgar una opinio..n pu..blica, a pesar de que eran reuniones so..lo para los nobles e intelectuales. Lograron la reforma poe..tica de la segunda mitad del siglo gracias a las conversaciones y las discusiones entre los tradicionalistas del gusto barroco y los neocla..sicos en las tertulias desde la Academia de Tri..pode hasta la tertulia de la Fonda de San Sebasti..an pasando por la Academia del Buen Gusto. En cuanto al triunfo del teatro neocla..sico en la segunda mitad del XVIII tambie..n debio. mucho a los salones de Olavide. Pero no llegaron a florecer las reformas realizadas por el propio Olavide y sus contertulianos en Sevilla porque la Inquisicio..n lo condeno. a Olavide por la hereji..a, lo cual nos muestra el li..mite de la Ilustracio..n espanola.

세르반테스와 라몬 데 라 끄루스의 막간극에 나타난 웃음의 기능

김재선 ( Kim Jae-seon ) 한국스페인어문학회 2006 스페인어문학 Vol.0 No.39

Dentro del escaso margen temporal, la comicidad siempre transporta la misma trascendencia en las diversas modificaciones del teatro breve. No obstante, su caracter o su funcion evoluciona de acuerdo con el sentido del humor propio de cada epoca y sociedad, relacionado con la vision del mundo. En este trabajo examinamos la funcion estetica de la risa del teatro breve -la liberadora (o carnavalesca) y la moralizadora-, sobre todo en los entremeses cervantinos y los sainetes de Ramon de la Cruz. Como si de sendas caras de una misma moneda se tratase, solo es visible una de las dos caracteristicas mientras que la otra queda encubierta segun su momento historico. Asi, en el Barroco se destaco evidentemente la carnavalesca; quedando oculta, pero no relegada, la moralizadora. En el Neoclasicismo se dio el proceso inverso. Por supuesto, hay diferencias en el grado de carnavalizacion y moralizacion segun las epocas. En cuanto a las normas sociales, la primera las transgrede revelando lo que es la realidad y los seres humanos, pero la segunda las defiende ensenando lo que deberia ser.