http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
3차 의료기관을 방문한 천식 환자에서 아토피 유병률의 변화
박흥우(Heung Woo Park),김상헌(Sang Heon Kim),김상훈(Sang Hoon Kim),장윤혜(Yoon Hae Chang),정희(Hee Chung),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1
N/A Background: The prevalence of atopy and atopy-related disease has been known to increase during the past decade. Objective : This study was desinged to evaluate the changes of atopy prevalence among asthmatic patients and the causative allergens. Method : A total of 698 asthmatic patients visiting Seoul National University Hospital in 1983, 1990 and 1997 was recruited. Skin prick test with common inhalant allergens was carried out and interpreted as positive when the mean wheal size formed by allergen was larger than 3 mm. Atopy was defined when skin reaction to one or more allegens was positive. Result. The prevalence of atopy among asthmatic patients was 54% in 1983, 48.8% in 1990 and 58% in 1997, respectively. The prevalence of atopy decreased as the age of patients in- creased. Recently, old asthmatic patients ( >55 years) showed a higher tendency to visit the tertiary referral hospital. When the data were analyzed according to age, the prevalence of atopy significantly increased among asthmatic patients aged 15-35 years, in whom the prevalence was 60.4% in 1988 and 81.3% in 1997 (p< 0.05). The positive rate of skin test to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen were significantly higher in 1997 than in 1983 (p < 0.05). Conclusion : The prevalence of atopy among asthmatic patients aged 15-85 years showed significant increase in 1997 compared to 1983. The changes of skin response to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen contributed to the increase of atopy.
스테로이드 의존성 천식 환자에서 스테로이드와 β2-아드레날린 수용체 mRNA의 발현양상
반준우 ( Joon Woo Bahn ),오선영 ( Sun Young Oh ),김세훈 ( Sae Hoon Kim ),장윤석 ( Yoon Seok Chang ),김우경 ( Woo Kyung Kim ),김상훈 ( Sang Hoon Kim ),김윤근 ( Yoon Keun Kim ),조상헌 ( Sang Heon Cho ),민경업 ( Kyung Up Min ),김유영 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Background:Steroid-dependency is one of phenotypes of severe asthma. Because steroid- dependent asthmatics require long-term systemic steroids to control their symptoms, they have potentially increased risks to experience serious adverse events caused by
만성기침 환자에서 유도객담내 호산구와 기관지과민성 및 천식 치료 반등도와의 관계
이병재(Byung Jae Lee),정재원(Jae Won Chung),장윤석(Yoon Suk Jang),장윤혜(Yoon Hae Chang),김상훈(Sang Hoon Kim),정희(Hee Chung),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.6
N/A Background: The value of the induced sputum examination in chronic cough has not been determined. We performed this study to investigate the relationship between eosinophil percentage on induced sputum and bronchial responsiveness to methacholine or capsaicin, and responses to anti-asthmatic treatment in chronic cough patients. Subjects and Methods Forty-seven patients with chronic cough persisting for more than 1 month without current wheezing or dyspnea were studied. According to the eosinophil percentage on induced sputum, the subjects were divided into two groups group A (sputum eosinophil ≥ 3%) and group B (sputum eosinophil < 3%). Methacholine bronchial provocation test (MBPT) and capsaicin challenge, and responses to anti-asthmatic treatment were compared between the two groups. Results : Group A consisted of 26 subjects and group B consisted of 21 subjects. There were no differences in sex, clinical characteristics of cough, atopy prevalence, and peripheral eosinophil counts except serum IgE level between the two groups. MBPT positivity was much higher in group A than group B (46.2% vs 0%, p<0.001), but there was no difference in capsaicin test positivity(44.0% vs 50.0%). Group A showed much higher response rates to anti-asthmatic treatments than in group B (73.1/o vs 19.09o, p(0,001). Conclusion : Eosinophilic airway inflammation in chronic cough was related to methacholine bronchial hyperresponsiveness, but not to capsaicin cough threshold. Induced sputum eosinophil percentage was a good indicator in predicting the response to anti-asthmatic treatment in most chronic cough patients. (J Asthma Allergy Clin Immunol 20: 895-905, 2000)
장윤석,Yoon Keun Kim,Seong Gyu Jeon,김세훈,Sun Sin Kim,박흥우,민경업,김유영,조상헌 대한면역학회 2013 Immune Network Vol.13 No.6
Der f 2 is the group 2 major allergen of a house dust mite (Dermatophagoides farinae) and its function has been recently suggested. To determine the optimal condition of sensitization to recombinant Der f 2 (rDer f 2) in murine model of asthma, we compared the effectiveness with different adjuvants in BALB/c and C57BL/6 mice. Mice from both strains sensitized with rDer f 2 by intraperitoneal injection or subcutaneous injection on days 1 and 14. The dosage was 20μg. Freund’s adjuvants with pertussis toxin (FP) or alum alone were used as adjuvants. On days 28, 29, and 30, mice were challenged intranasally with 0.1% rDer f 2. We evaluated airway hyperresponsivenss, eosinophil proportion in lung lavage, airway inflammation, and serum allergen specific antibody responses. Naive mice were used as controls. Airway hyperresponsiveness was increased in C57BL/6 with FP, and BALB/c with alum (PC200: 13.5±6.3, 13.2±6.7 vs. >50 mg/ml, p<0.05). The eosinophil proportion was increased in all groups; C57BL/6 with FP, BALB/c with FP, C57BL/6 with alum, BALB/c with alum (24.8±3.6, 20.3± 10.3, 11.0±6.9, 5.7±2.8, vs. 0.0±0.0%, p<0.05). The serum allergen specific IgE levels were increased in C57BL/6 with FP or alum (OD: 0.8±1.4, 1.1±0.8, vs. 0.0±0.0). C57BL/6 mice were better responders to rDer f 2 and as for adjuvants, Freund’s adjuvant with pertussis toxin was better