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약진(藥疹)으로 심한 소양감을 보인 환자에 대한 온청음(溫淸飮) 투여 1례
김영지,김미영,이승엽,최원우,황재웅,정재한,홍진우,나병조,문상관,Kim, Young-jee,Kim, Mi-young,Lee, Seung-yeop,Choi, Won-woo,Hwang, Jae-woong,Jeong, Jae-han,Hong, Jin-woo,Na, Byong-jo,Moon, Sang-kwan 대한중풍순환신경학회 2007 대한중풍.순환신경학회지 Vol.8 No.1
Drug eruption is a relatively commin dermatological disorder and may cause significant problems. The treatment is to stop using a drug that may cuase a drug eruption. In some cases, steroids and antihistamines can be used supportively. According to some reports, Onchungeum(溫淸飮) has steroid-like effects and antihistaminic effects. We administered Onchungeum(溫淸飮) a patient with severe itching because of a drug eruption. After administration of Onchungeum(溫淸飮), itching decreased to much degrees. It can be suggested that Onchungeum(溫淸飮) can be used to treat symptoms of allergic skin disease like a drug eruption.
한방병원에 입원한 뇌경색 환자의 기능회복과 관련된 특성에 대한 연구
김영지,김미영,이승엽,최원우,박주영,권승원,정우상,문상관,조기호,김영석,박성욱,박정미,고창남,배형섭,나병조,Kim, Young-Jee,Kim, Mi-Young,Lee, Seung-Yeop,Choi, Won-Woo,Park, Joo-Young,Kwon, Seung-Won,Jung, Woo-Sang,Moon, Sang-Kwan,Cho, Ki-Ho,Kim, Yo 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.4
Objectives : Stroke is the most common disabling neurological disease of adult life. The treatment and rehabilitation of stroke patients is an important and challenging area in the field of medicine. In Korea, a lot of stroke patients are treated using oriental medicine and there have been reports on their functional recovery. The aim of this study was to prove the therapeutic effect of oriental medicine on ischemic stroke. We also tried to identify characteristics of patients whose functional recovery was prominent and studied whether or not the use of fluids, anticoagulants, antiplatelets and neuroprotective agents increased the functional recovery of patients. Methods : We studied 794 patients within 2 weeks after first attack of ischemic stroke who were admitted to Kyung-Hee Oriental Medical Center from 1999 to 2000. Their maximum admission period was 60 days. Results : Motor power grade, NIHSS and MBI scores of patients improved during hospitalization significantly. Factors affecting functional recovery were admission period, motor power grade, NIHSS and MBI at admission. Age, waist-hip ratio and HDL cholesterol also affected functional recovery of patients. Whether or not fluids, anticoagulants, antiplatelets and neuroprotective agents were administered had nothing to do with functional recovery. Conclusion : Oriental medicine is effective for treatment and rehabilitation of ischemic stroke patients. When we manage stroke, we have to consider some important factors.
한국인 피부과환자에서 Methotrexate 치료효과 및 부작용
김영지 ( Young Jee Kim ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),원영호 ( Young Ho Won ),이승철 ( Seung Chul Lee ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.4
Background: Methotrexate (MTX) is a synthetic folic acid analogue with anti-proliferative and anti-inflammatoryproperties, and is prescribed for a variety of dermatological disorders. Objective: The aim of this study was to investigate the therapeutic responses, adverse effects, and risk factors ofMTX for dermatological use. Methods: We retrospectively evaluated age, gender, underlying diseases, initial and cumulative doses of MTX,treatment duration, physician’s global assessment (PGA) scores, and adverse effects in 200 dermatological patientstreated with MTX. Results: Various dermatoses responded to MTX in the following order of effectiveness: psoriasis vulgaris, pustularpsoriasis, pityriasis lichenoides, atopic dermatitis, mycosis fungoides, and morphea. Adverse effects of MTX wereobserved in 64 of the 200 patients (32%) as follows: elevated liver function tests (LFTs) in 36 (18%), nausea orvomiting in 22 (11%), complete blood count abnormalities in 5 (2.5%), and a burning sensation over the lesion in4 (2%). All patients who showed abnormal LFTs were normalized after reducing or stopping MTX, and the meantime to normalization was 5.76 weeks. Liver fibrosis was not found. Risk factors for MTX-related adverse effectswere old age (p=0.028), skin disease (p=0.018), high initial dose of MTX (p=0.023), and high cumulative dose ofMTX (p=0.044). Conclusion: Among various dermatoses, psoriasis showed an excellent response to MTX with relatively acceptablesafety in Koreans, but regular monitoring of MTX-related adverse effects is important. The risk factors for MTXrelatedadverse effects were old age, psoriasis, high initial dose, and high cumulative dose.
Helicobacter pylori 감염을 동반한 면역성저혈소판자반 1예
김영지 ( Young Jee Kim ),윤숙정 ( Sook Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Younh Ho Won ),이지범 ( Jee Bum Lee ) 대한피부과학회 2015 大韓皮膚科學會誌 Vol.53 No.4
면역성저혈소판자반(Immune thrombocytopenic purpura)은 항혈소판자가항체에 의한 자가면역질환으로, 다른 전혈구 검사의 이상 없이 혈소판 감소만을 보인다. 점출혈, 자반, 비출혈, 잇몸출혈, 월경과다, 멍이 잘 드는 증상을 보일수 있고, 드물게는 위장관계출혈, 혈뇨, 두개 내 출혈까지 동반되는 경우도 있다1. 면역저혈소판자반은 감염, 약물 등 과 관련된 경우도 있으며, 최근 Helicobacter pylori 감염과 관련이 있다는 보고가 증가하는 추세이다2. 환자는 20세 여성으로 2일 전부터 체간과 사지에 발생한 무증상의 자색반과 구강 내 출혈성 수포 및 출혈이 발생하여 내원하였다(Fig. 1). 피부의 긁은 자리에 출혈이 발생하고, 멍이 잘드는 경향 및 소량의 질출혈을 동반하였다. 가족력, 약물 복용력, 최근 예방접종력은 없었고, 10개월전 출산을 하였으나 당시 혈소판은 정상(324,000/μl)이었다. 전혈구 검사 및 말초혈액펴마름표본(PBS) 상 혈소판 1,000/μl로 감소된 소견 이외 다른 이상은 없었다. 체간의 자반에서 시행한 조직검사 상 진피 내 염증세포의 침윤을 동반하지 않은 적혈구의 혈관외유출이 관찰되었다(Fig. 2).다른 유사 질환을 배제하기 위해 시행한 항핵항체, β2-당단백, 루프스항응고인자, 직접 및 간접 쿰스 검사에서 모두음성 소견을 보였다. 골수조직검사 상 거대진핵세포(megakaryocyte)의 증가를 보였고, 복부 초음파 검사 상 간비증대는 관찰되지 않았다. 감염과의 관련성 평가 위해 시행한HIV, HBV, HCV, EBV, CMV에 대한 검사 모두 음성 소견이었다. 요소호기검사와 H. pylori 항원검사에서 양성 소견을 보여, H. pylori 감염과 관련된 면역성저혈소판자반으로 진단하였다. 혈소판 1,000/μl로 응급 치료 요하여, 항 RhD 면역글로불린 제제와 고용량 스테로이드 주사 치료를 시행하였다. 환자는 이후 혈소판 수치가 정상화 되었으며, 자색반과 구강 내 출혈 모두가 호전되었고, 스테로이드 감할 수 있는 질환이다. 흔한 원인이 되는 인자들에 대한 철저한 검사가 필요하고, 루프스나 백혈병과 같은 다른 질환을 배제하는 진단 과정이 필요하며, 본 증례처럼 혈소판의 큰 감소를 동반하여 응급 치료가 필요한 경우가 있다. H. pylori 감염 유병율이 높은 한국에서는 이와 관련된 면역성저혈소판자반에 대하여 인지할 필요가 있으며, 교육적인증례라 생각하여 보고 하는 바이다.
이승엽,김미영,김영지,최원우,민인규,박주영,정우상,문상관,조기호,김영석,Lee, Seung-Yeop,Kim, Mi-Young,Kim, Young-Jee,Choi, Won-Woo,Min, In-Kyu,Park, Joo-Young,Jung, Woo-Sang,Moon, Sang-Kwan,Cho, Ki-Ho,Kim, Young-Suk 대한중풍순환신경학회 2008 대한중풍.순환신경학회지 Vol.9 No.1
Meniere's disease is characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating hearing loss, tinnitus, and aural pressure. The primary histopathological correlate is endolymphatic hydrops, but its etiology is still disputed. Several medical therapies have been offered to patients with this disease since 1961 that the first report had been given by Prosper Meniere. Some will be helpful for relieving the symptoms but there is still no absolutely effective treatment to cure the disease. One male patient with Meniere's disease was hospitalized in Kyung-Hee medical center, and we treated him with oriental medical therapies. The treatment was effective to relieve his symptoms, and they had been successfully controlled until he was discharged from hospital. The result suggests that the oriental medical therapy is safe and helpful to patients with Meniere's disease, so we reported this case.
급성기 중풍환자의 발병시간에 따른 특성 및 위험인자 연구
김미영,김영지,이승엽,최원우,임정태,김창현,민인규,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Mi-Young,Kim, Young-Jee,Lee, Seung-Yeop,Choi, Won-Woo,Leem, Jung-Tae,Kim, Chang-Hyun,Min, In-Kyu,Park, Sung-Week,Jung, Woo-Sang,Moon, S 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : The aim of this study was to assess the distribution of general characteristics and risk factors according to onset time in acute stroke patients. Methods : We studied hospitalized patients within 4 wks after the onset of stroke who were admitted to the Department of Internal Medicine at Kyunghee University Oriental Medical Hospital, Kyunghee University East-West Neo Medical Hospital, Kyungwon University Songpa Oriental Medical Hospital, Kyungwon University Incheon Oriental Medical Hospital, and Dongguk University Ilsan Oriental Medical Hospital from April 2007 to August 2008. The 24-hour day was divided into quartiles (6:00 to 12:00, 12:00 to 18:00, 18:00 to 24:00 and 24:00 to 6:00). We analyzed the general characteristics and risk factors according to onset time in acute stroke patients. Results : 468 subjects were included into the final analysis. 1. The most common time period for ischemic stroke onset was between 6:00 and 12:00. It demonstrated a 50% excess risk between 6:00 and 12:00. 2. On the demographic variables of the patients, the rate of hypertension was significantly higher from 18: 00 to 24: 00 than 24:00 to 6:00. 3. There was no significant difference of stroke type, Sasang constitution, or lifestyle between times. 4. According to the blood test, high density lipoprotein cholesterol was significantly higher at 24:00 to 6:00 and lower at 12:00 to 18:00 than other time-groups. 5. The patients diagnosed with metabolic syndrome were significantly more at 12:00 to 18:00 and fewer at 24:00 to 6:00. 6. Hypertension and coffee drinking showed close relationship with patients whose stroke occurred while awake in multivariate analysis. Conclusions : The above results showed that the overall tendency of acute stage cerebral infarction patients varied according to their onset time. These results can be utilized in the future as a basis material.
항생제로 유발된 Pseudomembranous Colitis환자의 이중탕(理中湯) 치료 1례
최원우,김미영,김영지,이승엽,민인규,홍진우,나병조,정우상,Choi, Won-woo,Kim, Mi-young,Kim, Young-jee,Lee, Seung-yeop,Min, In-kyu,Hong, Jin-woo,Na, Byong-jo,Jung, Woo-sang 대한중풍순환신경학회 2007 대한중풍.순환신경학회지 Vol.8 No.1
Objective : Stroke patients tend to take antibiotics due to infection resulting from complication. One of many side effects from using antibiotics is diarrhea, which infact causes anaerobic organism dysfunction resulting Pseudo-Membranous Colitis (P.M.C). To treat P.M.C, antibiotics and antibacterial agents are usually used. But they may cause other side effects, therefore extreme caution must be taken. Methods : We treated an antibiotic induced P.M.C patient who diagnosed by sigmoid scopy with only Yijoong-tang (Lizhong-tang) without antibiotics and observed patients stool aspects. Results and Conclusion : Patiensts symptom was improved after 7days, and we can see the improvement by follow-up sigmoid scopy. This case may give us a possibility of that oriental medical treatments as complementary and alternative medicine to standard antibiotic treatment.
CAVI를 이용한 급성기 중풍환자의 Arteriosclerosis와 한방변증의 관련성 연구
최원우,김미영,김영지,이승엽,임정태,김창현,민인규,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Choi, Won-Woo,Kim, Mi-Young,Kim, Young-Jee,Lee, Seung-Yeop,Leem, Jung-Tae,Kim, Chang-Hyun,Min, In-Kyu,Park, Sung-Wook,Jung, Woo-Sang,Moon, S 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.4
Objectives : This study aimed to clarify the relationship between the Oriental medical diagnosis and arteriosclerosis by measuring carotid-ankle vascular index(CAVI) in acute cerebral infarction patients. Method : One hundred thirty-one subjects were recruited from the patients admitted to the Internal Medical Department at Kyunghee University Oriental Medical Center from April 2007 to August 2008. We sorted cerebral infarction patients and assessed one hundred fourteen patients' CAVI data. We diagnosed dampness-phlegm by Oriental medical diagnosis and evaluated stroke type by single or multiple infarctions. then, we analyzed their characteristics with type of stroke, risk factor, lifestyle, metabolic syndrome and dampness-phlegm diagnosis. Result : 1. On the demographic variables of the patients, age, hypertension, hyperlipidemia, multiple infarction group and metabolic syndrome and dampness-phlegm group were significantly higher in the high CAVI score group than in the control. 2. According to the significant difference in the dampness-phlegm group, we analyzed dampness-phlegm related index for pattern identifications by CAVI score. As a result, dark circles, insomnia, headache, white coating tongue. slippery pulse, and rough pulse were significantly higher in the high CAVI score group then in the control. 3. In multivariate analysis, age, hypertension, multiple infarction and dampness-phlegm groups showed a close relationship with the high CAVI score group. Conclusions : According to the analysis, significance between dampness-phlegm diagnosed patients group and high CAVI score were clarified. Moreover, multiple location infarctions also have a relationship with high CAVI score in cerebral infarction patients. These results can be utilized in the future as a basis material.