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한승우 ( Han Seung U ),김신윤 ( Kim Sin Yun ),강영모 ( Kang Yeong Mo ) 대한내과학회 2003 대한내과학회지 Vol.65 No.3
목적 : TGF-β1은 조직 복구기능 및 면역 조절기능을 통해서 류마티스 관절염에 중요한 역할을 담당하는 다기능의 사이토카인이다. TGF-β1의 단일핵산다형성(single nucleotide polymorphism, SNP)들과 류마티스 관절염의 관계는 아직 명확히 알려져 있지 않으며 저자들은 TGF-β1 유전자에 있는 5개 부위의 SNP에 대해 류마티스 관절염의 관련 여부를 조사하였다. 방법 : 경북대학교병원에 내원한 류마티스 관절염 환자 110명과 Background : Transforming growth factor-β1 (TGF-β1) has been shown to promote tissue repair and have immunosuppressive actions, and has been proposed to have a role in rheumatoid arthritis (RA). In this study, we have analyzed the association of five know
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김영욱,정한준,윤봉호,김신윤,이상국,변경환,김태헌 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1
Deep vein thrombosis is recognized as a common complication in surgical patients in western countries especially in patients with high risk factors. The purposes of this study were to detect leg DVTs in early postoperative period by non-invasive surveillance and to analyze the risk factors of DVT. One hundred seventy one patients who underwent major operations(67 curative resection of colorectal cancer, 64 total hip replacement, 38 femur operation for fracture, and 2 colon resections for benign colon disease) were included for the prospective surveillance of leg DVT within 2 weeks after the operations. For the surveillance of leg DVT, strain gauge plethysmography(SPG) and Duplex scanning of both legs were completed for all patients except 10 patients. These 10 patients were examined in only one leg. The patients with past history of leg DVT or under prophylactic anticoagulant therapy were excluded from this study. To determine the risk factors related with leg DVT formation, age and sex of the patients, indication of surgery or surgical procedures, duration of operation, position during the operation, duration of postoperative immobilization, and preoperative serum level of antithrombin III (AT- III) were analyzed using Chi-square test. After performing SPG of 342 legs, 38 legs, showed abnormal on venous outflow/venous capacitance discriminant line chart, and 13 legs of 12 patients showed the finding(s) suggesting DVT on duplex scanning. Among the patients with abnormal duplex findings, 7 limbs(53.8%) were symptomatic, but the remaining 6 legs were silent. In 6 (15.8%) patients of 36 femur operations, 3(4.7%) of 64 total hip replacements and 3(4.5%) of 67 curative resections of colorectal cancer developed DVT by duplex scanning in the iliac(5), femoral-popliteal(6), and isolated calf(2) veins. After analyzing the risk factors, we could not find any statistically significant(p<0.05) factor related with leg DVT.